Patrick Stauffer
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View article: HAND GRIP STRENGTH IS ASSOCIATED WITH CLINICAL SYMPTOM BURDEN IN CROHN'S DISEASE
HAND GRIP STRENGTH IS ASSOCIATED WITH CLINICAL SYMPTOM BURDEN IN CROHN'S DISEASE Open
INTRODUCTION Inflammatory bowel disease (IBD) is a chronic inflammatory condition that may result in malnutrition and alteration of body composition, such as the development of sarcopenia. Sarcopenia is a known component of frailty, which …
View article: Axial spondyloarthritis patients have altered mucosal IgA response to oral and fecal microbiota
Axial spondyloarthritis patients have altered mucosal IgA response to oral and fecal microbiota Open
Axial spondyloarthritis (axSpA) is an inflammatory arthritis involving the spine and the sacroiliac joint with extra-articular manifestations in the eye, gut, and skin. The intestinal microbiota has been implicated as a central environment…
View article: Pneumocystis jiroveci pneumonia prophylaxis in patients with autoimmune hepatitis
Pneumocystis jiroveci pneumonia prophylaxis in patients with autoimmune hepatitis Open
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View article: Axial spondyloarthritis patients have altered mucosal IgA response to oral and fecal microbiota
Axial spondyloarthritis patients have altered mucosal IgA response to oral and fecal microbiota Open
Objective To investigate whether axial spondyloarthritis (AxSpA) patients have an altered immunoglobulin A (IgA) response in the gut and oral microbial communities. Methods We performed 16S rRNA gene (16S) sequencing on IgA positive (IgA +…
View article: Gene Expression Profiling and Heterogeneity of Nonspecific Orbital Inflammation Affecting the Lacrimal Gland
Gene Expression Profiling and Heterogeneity of Nonspecific Orbital Inflammation Affecting the Lacrimal Gland Open
Gene expression profiling discloses clear heterogeneity among patients with lacrimal inflammatory disease. Comparison of the expression profiles suggests that a subset of patients with nonspecific dacryoadenitis might have a limited form o…
View article: Intestinal Metabolites Are Profoundly Altered in the Context of HLA–B27 Expression and Functionally Modulate Disease in a Rat Model of Spondyloarthritis
Intestinal Metabolites Are Profoundly Altered in the Context of HLA–B27 Expression and Functionally Modulate Disease in a Rat Model of Spondyloarthritis Open
Objective HLA–B27–associated spondyloarthritides are associated with an altered intestinal microbiota and bowel inflammation. We undertook this study to identify HLA–B27–dependent changes in both host and microbial metabolites in the HLA–B…
View article: Does the Urinary Microbiome Play a Role in Urgency Urinary Incontinence and Its Severity?
Does the Urinary Microbiome Play a Role in Urgency Urinary Incontinence and Its Severity? Open
Our study provides further characterization of the urinary microbiome in both healthy controls and extensively phenotyped women with UUI. Our results also suggest that the urinary microbiome may play an important role in the pathophysiolog…
View article: Perturbed Mucosal Immunity and Dysbiosis Accompany Clinical Disease in a Rat Model of Spondyloarthritis
Perturbed Mucosal Immunity and Dysbiosis Accompany Clinical Disease in a Rat Model of Spondyloarthritis Open
Objective The HLA–B27/β 2 ‐microglobulin (β 2 m)–transgenic (Tg) rat is a leading model of B27‐associated spondyloarthritis (SpA), and the disease is dependent on the presence of intestinal bacteria. Previous studies have shown that adult …
View article: The Role of the Immune Response in the Pathogenesis of Thyroid Eye Disease: A Reassessment
The Role of the Immune Response in the Pathogenesis of Thyroid Eye Disease: A Reassessment Open
This is the first study to compare gene expression in TED to gene expression associated with other causes of exophthalmos. The juxtaposition shows that inflammatory markers are far less characteristic of TED relative to other orbital infla…
View article: Fibrosis, gene expression and orbital inflammatory disease
Fibrosis, gene expression and orbital inflammatory disease Open
A pathologist's recognition of fibrosis in orbital tissue correlates well with increased expression of transcripts that are considered essential in fibrosis. Many transcripts implicated in orbital fibrosis have been previously implicated i…
View article: Parallel Gene Expression Changes in Sarcoidosis Involving the Lacrimal Gland, Orbital Tissue, or Blood
Parallel Gene Expression Changes in Sarcoidosis Involving the Lacrimal Gland, Orbital Tissue, or Blood Open
Gene expression in sarcoidosis involving the orbit or lacrimal gland can be distinguished from gene expression patterns in control tissue and overlaps with many transcripts upregulated or downregulated in the peripheral blood of patients w…