Patrick J. Strollo
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View article: 1317 Addressing OSA Care in Rural Communities: Development of the West Virginia OSA Academic Mentoring Partnership
1317 Addressing OSA Care in Rural Communities: Development of the West Virginia OSA Academic Mentoring Partnership Open
Introduction This study used implementation science and community engaged research methods to address a significant care gap for obstructive sleep apnea (OSA) in West Virginia (WV). To this end, we designed an intervention to support prima…
View article: 1318 Initial Implementation Outcomes of the West Virginia Obstructive Sleep Apnea Academic Mentoring Partnership
1318 Initial Implementation Outcomes of the West Virginia Obstructive Sleep Apnea Academic Mentoring Partnership Open
Introduction There is a critical need to create sustainable interventions for the nearly 80% of patients with undiagnosed obstructive sleep apnea (OSA), particularly in rural communities where notable health disparities exist. The West Vir…
View article: 0720 Effect of Hypoglossal Nerve Stimulation on Hypoxic Burden: Analysis of the STAR Trial
0720 Effect of Hypoglossal Nerve Stimulation on Hypoxic Burden: Analysis of the STAR Trial Open
Introduction Hypoglossal nerve stimulation (HGNS) is an implantable device for treating Obstructive Sleep Apnea (OSA) by electrically stimulating the hypoglossal nerve to move the tongue and relieve airway obstruction. The STAR trial showe…
View article: 0783 Demographic and Baseline Disease Characteristics of SynAIRgy: A Phase 3 Trial of Aroxybutynin and Atomoxetine (AD109) in Obstructive Sleep Apnea
0783 Demographic and Baseline Disease Characteristics of SynAIRgy: A Phase 3 Trial of Aroxybutynin and Atomoxetine (AD109) in Obstructive Sleep Apnea Open
Introduction AD109 is a combination of a novel antimuscarinic, aroxybutynin (aroxy; R-enantiomer of oxybutynin), and the selective norepinephrine reuptake inhibitor atomoxetine (ato). We report the sample characteristics of the fully enrol…
View article: 0748 Impacts of HGNS on Hypoxic Burden
0748 Impacts of HGNS on Hypoxic Burden Open
Introduction Hypoxic burden (HB) is a novel metric used to characterize the physiological impact of obstructive sleep apnea (OSA). Prior studies have shown HB to strongly correlate with cardiovascular (CV) risk. While the hypoglossal nerve…
View article: Three-dimensional mean disease alleviation (3D-MDA): The next step in measuring sleep apnea treatment effectiveness
Three-dimensional mean disease alleviation (3D-MDA): The next step in measuring sleep apnea treatment effectiveness Open
Mean disease alleviation measures the effectiveness of Obstructive Sleep Apnea (OSA) treatments. It combines a patient's adherence to treatment normalized to their total sleep time and the treatment's efficacy as determined by the change i…
View article: Analysis of Recent Sleep Surgery Fellowship Training
Analysis of Recent Sleep Surgery Fellowship Training Open
Objective Since 2011, otolaryngologists aiming to become certified in sleep medicine have had to complete an ACGME accredited sleep medicine fellowship. In addition to standard sleep medicine and sleep surgery fellowships, several institut…
View article: 0546 Aroxybutynin and Atomoxetine for the Treatment of OSA: Rationale and Design of the SYNAIRGY Phase 3 RCT
0546 Aroxybutynin and Atomoxetine for the Treatment of OSA: Rationale and Design of the SYNAIRGY Phase 3 RCT Open
Introduction There are no FDA-approved drugs available for the treatment of obstructive sleep apnea (OSA). The relaxation of upper airway muscles at sleep onset and insufficient muscle reactivation during obstructive events are the key pat…
View article: Oral appliance therapy and hypoglossal nerve stimulation as non-positive airway pressure treatment alternatives for obstructive sleep apnea: a narrative expert review
Oral appliance therapy and hypoglossal nerve stimulation as non-positive airway pressure treatment alternatives for obstructive sleep apnea: a narrative expert review Open
This perspective on alternatives to positive airway pressure (PAP) therapy for the treatment of obstructive sleep apnea (OSA) summarizes the proceedings of a focus group that was conducted by the Sleep Research Society Foundation. This per…
View article: Hypoglossal Nerve Stimulation and Cardiovascular Outcomes for Patients With Obstructive Sleep Apnea
Hypoglossal Nerve Stimulation and Cardiovascular Outcomes for Patients With Obstructive Sleep Apnea Open
Importance Sham-controlled trials are needed to characterize the effect of hypoglossal nerve stimulation (HGNS) therapy on cardiovascular end points in patients with moderate-severe obstructive sleep apnea (OSA). Objective To determine the…
View article: 0535 Impact of hypoglossal nerve stimulation surgery alone on sleep disordered breathing and sleepiness
0535 Impact of hypoglossal nerve stimulation surgery alone on sleep disordered breathing and sleepiness Open
Introduction Hypoglossal Nerve Stimulation (HNS) is an established option for CPAP -intolerant obstructive sleep apnea (OSA) patients, with multiple studies demonstrating safety and effectiveness. There are known nightly variations in OSA …
View article: Provider Perspectives on Sleep Apnea from Appalachia: A Mixed Methods Study
Provider Perspectives on Sleep Apnea from Appalachia: A Mixed Methods Study Open
West Virginia (WV) has the highest rates of obesity and cardiopulmonary disease in the United States (U.S.). Recent work has identified a significant care gap in WV for obstructive sleep apnea (OSA). This OSA care gap likely has significan…
View article: REM-Predominant Obstructive Sleep Apnea in Patients with Coronary Artery Disease
REM-Predominant Obstructive Sleep Apnea in Patients with Coronary Artery Disease Open
Obstructive sleep apnea (OSA) is common in adults with coronary artery disease (CAD). OSA that occurs predominantly during rapid-eye movement (REM) sleep has been identified as a specific phenotype (REM-predominant OSA) in sleep clinic coh…
View article: Hypoglossal nerve stimulation versus positive airway pressure therapy for obstructive sleep apnea
Hypoglossal nerve stimulation versus positive airway pressure therapy for obstructive sleep apnea Open
Purpose Hypoglossal nerve stimulation (HNS) has been shown to treat obstructive sleep apnea (OSA) effectively. The aim of this study was to compare HNS with positive airway pressure (PAP) treatment regarding outcome parameters: (1) sleepin…
View article: 0571 Associations Between Sleep Problems and Cardiovascular Disease and All-Cause Mortality in Asthma-COPD Overlap
0571 Associations Between Sleep Problems and Cardiovascular Disease and All-Cause Mortality in Asthma-COPD Overlap Open
Introduction Sleep problems (i.e., short and long sleep duration and sleep disorders) are common in persons with either asthma or chronic obstructive pulmonary disease (COPD) and have been linked to increased cardiovascular risk and mortal…
View article: 0378 Daytime PAP Accommodation: A Breath of Fresh Air
0378 Daytime PAP Accommodation: A Breath of Fresh Air Open
Introduction Rising healthcare costs and resource utilization represents a growing problem in the United States, especially for individuals with progressive neuromuscular disorders. Diagnosis and treatment of obstructive sleep apnea has be…
View article: 0772 Clusters of Upper Airway Stimulation Adherence Patterns in the First 90 Days
0772 Clusters of Upper Airway Stimulation Adherence Patterns in the First 90 Days Open
Introduction Upper airway stimulation (UAS) therapy is effective for a subset of obstructive sleep apnea (OSA) patients with CPAP intolerance. While overall adherence is high, some patients have suboptimal adherence to UAS, which limits ef…
View article: Cluster analysis of upper airway stimulation adherence patterns and implications on clinical care
Cluster analysis of upper airway stimulation adherence patterns and implications on clinical care Open
Study Objectives Upper airway stimulation (UAS) therapy is effective for a subset of obstructive sleep apnea (OSA) patients with continuous positive airway pressure (CPAP) intolerance. While overall adherence is high, some patients have su…