Patrick Sven Plum
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View article: Liquid biopsies for risk stratification of intraductal papillary mucinous neoplasms
Liquid biopsies for risk stratification of intraductal papillary mucinous neoplasms Open
View article: Artificial neural networks as a prognostic tool using hyperspectral imaging on pretherapeutic histopathological specimens of esophageal adenocarcinoma
Artificial neural networks as a prognostic tool using hyperspectral imaging on pretherapeutic histopathological specimens of esophageal adenocarcinoma Open
View article: Single-cell analysis of Barrett’s esophagus and carcinoma reveals cell types conferring risk via genetic predisposition
Single-cell analysis of Barrett’s esophagus and carcinoma reveals cell types conferring risk via genetic predisposition Open
Inherited genetic variants contribute to Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC), but it is unknown which cell types are involved in this process. We performed single-cell RNA sequencing of BE, EAC, and paired normal t…
View article: Long-term survival in peritoneal mesothelioma treated with 24 consecutive PIPACs
Long-term survival in peritoneal mesothelioma treated with 24 consecutive PIPACs Open
Objectives Malignant peritoneal mesothelioma (MPM) is a rare disease with unspecific abdominal symptoms which is therefore often diagnosed at an advanced stage. Curative therapy is delivered by radical surgery, whereas palliative therapy c…
View article: Life’s essential 8 and specific cancer risk and mortality in men and women: a population-based cohort analysis of 332,417 United Kingdom participants
Life’s essential 8 and specific cancer risk and mortality in men and women: a population-based cohort analysis of 332,417 United Kingdom participants Open
Background This study aimed to explore the association between Life’s Essential 8 (LE8) and the risk of cancer occurrence and cancer-associated mortality across 24 cancer types. The cardiovascular health (CVH) score is constructed based on…
View article: Upper Gastrointestinal Tumors during Pregnancy: Diagnosis, Risk Factors, and Treatment Options – A Literature Review
Upper Gastrointestinal Tumors during Pregnancy: Diagnosis, Risk Factors, and Treatment Options – A Literature Review Open
Background: Malignant (and benign) tumors of the upper gastrointestinal tract are very rare in pregnancy and can be difficult to diagnose because their symptoms are often misinterpreted as “typical” symptoms of pregnant women like vomiting…
View article: Oncologic Surgery for Lower Gastrointestinal Tumors during Pregnancy: A Literature Review
Oncologic Surgery for Lower Gastrointestinal Tumors during Pregnancy: A Literature Review Open
Background: Colorectal cancer (CRC) during pregnancy can be a challenging situation due to the spatial confinement of the tumor with the growing uterus carrying the fetus. It is one of the more common tumor entities occurring in pregnant w…
View article: Diagnostic Accuracy and Reliability of CT-based Node-RADS for Esophageal Cancer
Diagnostic Accuracy and Reliability of CT-based Node-RADS for Esophageal Cancer Open
The Node-RADS score on staging CT is associated with the malignancy rate of lymph nodes in patients with EC with only moderate diagnostic accuracy. The inter-reader variability is moderate, which could pose difficulties for translation int…
View article: Gene expression adaptation of metastases to their host tissue
Gene expression adaptation of metastases to their host tissue Open
The adaptation of metastatic cells to their host tissue critically determines the pathogenicity of a cancer and therefore patient survival. Yet, it remains elusive to what extent the host environment drives gene expression programs in meta…
View article: Single cell analysis of Barrett’s esophagus and carcinoma reveals cell types conferring risk via genetic predisposition
Single cell analysis of Barrett’s esophagus and carcinoma reveals cell types conferring risk via genetic predisposition Open
Inherited genetic variants contribute to Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC) but it is unknown which cell types are involved in this process. We performed single cell RNA-sequencing of BE, EAC and paired normal tis…
View article: State-of-the-Art Surgery in Achalasia
State-of-the-Art Surgery in Achalasia Open
Background: Achalasia is a motility disorder of the esophagus and depending on its type, esophageal tubular hypo- or hypermotility can cause typical symptoms, such as dysphagia, chest pain, weight loss, or regurgitation. Clinical symptoms …
View article: Bone mineral density as a prognostic marker in patients with biliary tract cancer undergoing surgery
Bone mineral density as a prognostic marker in patients with biliary tract cancer undergoing surgery Open
Background Biliary tract cancer (BTC) is one of the most aggressive malignancies and surgery represents the only curative treatment approach. However, even in patients with complete tumor resection 5-year survival rates are below 30%. So f…
View article: Association between four insulin resistance surrogates and the risk of esophageal cancer: a prospective cohort study using the UK Biobank
Association between four insulin resistance surrogates and the risk of esophageal cancer: a prospective cohort study using the UK Biobank Open
View article: Integrative genomic analyses of European intrahepatic cholangiocarcinoma: Novel <i>ROS1</i> fusion gene and PBX1 as prognostic marker
Integrative genomic analyses of European intrahepatic cholangiocarcinoma: Novel <i>ROS1</i> fusion gene and PBX1 as prognostic marker Open
Background Cholangiocarcinoma (CCA) is a fatal cancer of the bile duct with a poor prognosis owing to limited therapeutic options. The incidence of intrahepatic CCA (iCCA) is increasing worldwide, and its molecular basis is emerging. Envir…
View article: Premature mortality for patients after completely resected early adenocarcinoma of the esophagus or stomach
Premature mortality for patients after completely resected early adenocarcinoma of the esophagus or stomach Open
Objective To establish the life expectancy burden of esophago‐gastric cancer by analyzing years of life lost (YLL) for a Western patient population after treatment of early esophageal (EAC) or early gastric (GAC) adenocarcinoma. Background…
View article: Therapy-relevant <i>MDM2</i> amplification in cholangiocarcinomas in Caucasian patients
Therapy-relevant <i>MDM2</i> amplification in cholangiocarcinomas in Caucasian patients Open
Background: Cholangiocarcinomas (CCA) are a group of aggressive malignancies with poor prognosis. The distinct subtypes are related to different etiologies and genetic aberrations that are subject to targeted therapies. Mouse double minute…
View article: Pan-cancer analysis and in vitro validation of the oncogenic and prognostic roles of AURKA in human cancers
Pan-cancer analysis and in vitro validation of the oncogenic and prognostic roles of AURKA in human cancers Open
Background Aurora kinase A (AURKA) plays a pivotal role in regulating cell mitosis and tumor progression. However, its prognostic significance across diverse cancer types remains relatively unexplored. Methods We conducted a comprehensive …
View article: Extension of resection after positive intraoperative pathology during surgery for gastric and gastroesophageal junction adenocarcinoma: a retrospective cohort study
Extension of resection after positive intraoperative pathology during surgery for gastric and gastroesophageal junction adenocarcinoma: a retrospective cohort study Open
Background: Residual tumor at the resection margins after surgery for gastric and gastroesophageal junction (GEJ) adenocarcinoma is a known prognostic factor. In this single-center, retrospective cohort study in a tertiary referral center,…
View article: Long-Term Postsurgical Outcomes of Neoadjuvant Chemoradiation (CROSS) Versus Chemotherapy (FLOT) for Multimodal Treatment of Adenocarcinoma of the Esophagus and the Esophagogastric Junction
Long-Term Postsurgical Outcomes of Neoadjuvant Chemoradiation (CROSS) Versus Chemotherapy (FLOT) for Multimodal Treatment of Adenocarcinoma of the Esophagus and the Esophagogastric Junction Open
Background The question of the ideal neoadjuvant therapy for locally advanced esophagogastric adenocarcinoma has not been answered to date. Multimodal treatment has become a standard treatment for these adenocarcinomas. Currently, perioper…
View article: Two decades of gastric and gastroesophageal junction cancer surgery
Two decades of gastric and gastroesophageal junction cancer surgery Open
View article: Predicting the HER2 status in oesophageal cancer from tissue microarrays using convolutional neural networks
Predicting the HER2 status in oesophageal cancer from tissue microarrays using convolutional neural networks Open
Background Fast and accurate diagnostics are key for personalised medicine. Particularly in cancer, precise diagnosis is a prerequisite for targeted therapies, which can prolong lives. In this work, we focus on the automatic identification…
View article: Trophoblast Cell Surface Antigen 2 (TROP2) as a Predictive Bio-Marker for the Therapeutic Efficacy of Sacituzumab Govitecan in Adenocarcinoma of the Esophagus
Trophoblast Cell Surface Antigen 2 (TROP2) as a Predictive Bio-Marker for the Therapeutic Efficacy of Sacituzumab Govitecan in Adenocarcinoma of the Esophagus Open
Introduction: The Trophoblast cell surface antigen 2 (TROP2) is expressed in many carcinomas and may represent a target for treatment. Sacituzumab govitecan (SG) is a TROP2–directed antibody-drug conjugate (ADC). Nearly nothing is known ab…
View article: HER2 overexpression in gastroesophageal adenocarcinoma from immunohistochemstry imaging.
HER2 overexpression in gastroesophageal adenocarcinoma from immunohistochemstry imaging. Open
HER2 overexpression in gastroesophageal adenocarcinoma from immunohistochemstry imaging. Primary dataset used in Predicting the HER2 status in esophageal cancer from tissue microarrays using convolutional neural networ…
View article: HER2 overexpression in gastroesophageal adenocarcinoma from immunohistochemstry imaging.
HER2 overexpression in gastroesophageal adenocarcinoma from immunohistochemstry imaging. Open
HER2 overexpression in gastroesophageal adenocarcinoma from immunohistochemstry imaging. Primary dataset used in Predicting the HER2 status in esophageal cancer from tissue microarrays using convolutional neural networ…
View article: Predicting the HER2 status in esophageal cancer from tissue microarrays using convolutional neural networks
Predicting the HER2 status in esophageal cancer from tissue microarrays using convolutional neural networks Open
Background Fast and accurate diagnostics are key for personalized medicine. Particularly in cancer, precise diagnosis is a prerequisite for targeted therapies which can prolong lives. In this work we focus on the automatic identification o…
View article: Fructose-1,6-bisphosphatase 1 (FBP1) is an independent biomarker associated with a favorable prognosis in esophageal adenocarcinoma
Fructose-1,6-bisphosphatase 1 (FBP1) is an independent biomarker associated with a favorable prognosis in esophageal adenocarcinoma Open
View article: Effect of phone call distraction on the performance of medical students in an OSCE
Effect of phone call distraction on the performance of medical students in an OSCE Open
View article: Short- and long-term follow-up of patients with non-neoplastic esophageal perforation
Short- and long-term follow-up of patients with non-neoplastic esophageal perforation Open
View article: Tumor Microenvironment of Esophageal Cancer
Tumor Microenvironment of Esophageal Cancer Open
Esophageal cancer is among the top ten most deadly cancers worldwide with adenocarcinomas of the esophagus showing increasing incidences over the last years. The prognosis is determined by tumor stage at diagnosis and in locally advanced s…
View article: Palliation of malignant dysphagia with a segmented self-expanding metal stent
Palliation of malignant dysphagia with a segmented self-expanding metal stent Open
Self-expanding metal stents (SEMSs) in different geometric shapes are an established palliative treatment for malignant tumors of the esophagus. Mechanical properties and stent design have an impact on patient comfort, migration rate, and …