Explanipedia

Interface astrogliosis in contact sport head impacts and military blast exposure Open

Katharine J. Babcock, Bobak Abdolmohammadi, Patrick T. Kiernan, Ian Mahar, Jonathan D. Cherry , et al. · 2022

Exposure to military blast and repetitive head impacts (RHI) in contact sports is associated with increased risk of long-term neurobehavioral sequelae and cognitive deficits, and the neurodegenerative disease chronic traumatic encephalopat…

The Second NINDS/NIBIB Consensus Meeting to Define Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy Open

Kevin F. Bieniek, Nigel J. Cairns, John F. Crary, Dennis W. Dickson, Rebecca D. Folkerth , et al. · 2021

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder associated with exposure to head trauma. In 2015, a panel of neuropathologists funded by the NINDS/NIBIB defined preliminary consensus neuropathological criteria for CT…

Nonhomogeneous Gadolinium Retention in the Cerebral Cortex after Intravenous Administration of Gadolinium-based Contrast Agent in Rats and Humans Open

Olga Minaeva, Ning Hua, Erich S. Franz, Nicola Lupoli, Asim Mian , et al. · 2019

Background Gadolinium retention after repeated gadolinium-based contrast agent (GBCA) exposure has been reported in subcortical gray matter. However, gadolinium retention in the cerebral cortex has not been systematically investigated. Pur…

Duration of American Football Play and Chronic Traumatic Encephalopathy Open

Jesse Mez, Daniel H. Daneshvar, Bobak Abdolmohammadi, Alicia S. Chua, Michael L. Alosco , et al. · 2019

Objective Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with exposure to contact and collision sports, including American football. We hypothesized a dose–response relationship between duration of footbal…

Variation in TMEM106B in chronic traumatic encephalopathy Open

Jonathan D. Cherry, Jesse Mez, John F. Crary, Yorghos Tripodis, Victor E. Alvarez , et al. · 2018

Lewy Body Pathology and Chronic Traumatic Encephalopathy Associated With Contact Sports Open

Jason W. Adams, Victor E. Alvarez, Jesse Mez, Bertrand R. Huber, Yorghos Tripodis , et al. · 2018

Traumatic brain injury has been associated with increased risk of Parkinson disease and parkinsonism, and parkinsonism and Lewy body disease (LBD) can occur with chronic traumatic encephalopathy (CTE). To test whether contact sports and CT…

Age of first exposure to tackle football and chronic traumatic encephalopathy Open

Michael L. Alosco, Jesse Mez, Yorghos Tripodis, Patrick T. Kiernan, Bobak Abdolmohammadi , et al. · 2018

Objective To examine the effect of age of first exposure to tackle football on chronic traumatic encephalopathy (CTE) pathological severity and age of neurobehavioral symptom onset in tackle football players with neuropathologically confir…

Characterization of Detergent Insoluble Proteome in Chronic Traumatic Encephalopathy Open

Jonathan D. Cherry, Ahmad Zeineddin, Eric B. Dammer, James Webster, Duc M. Duong , et al. · 2017

Quantitative proteomics of postmortem human brain can identify dysfunctional proteins that contribute to neurodegenerative disorders like Alzheimer disease (AD) and frontotemporal dementia. Similar studies in chronic traumatic encephalopat…

CCL11 is increased in the CNS in chronic traumatic encephalopathy but not in Alzheimer’s disease Open

Jonathan D. Cherry, Thor D. Stein, Yorghos Tripodis, Victor E. Alvarez, Bertrand R. Huber , et al. · 2017

CCL11, a protein previously associated with age-associated cognitive decline, is observed to be increased in the brain and cerebrospinal fluid (CSF) in chronic traumatic encephalopathy (CTE) compared to Alzheimer's disease (AD). Using a co…

Clinicopathological Evaluation of Chronic Traumatic Encephalopathy in Players of American Football Open

Jesse Mez, Daniel H. Daneshvar, Patrick T. Kiernan, Bobak Abdolmohammadi, Victor E. Alvarez , et al. · 2017

In a convenience sample of deceased football players who donated their brains for research, a high proportion had neuropathological evidence of CTE, suggesting that CTE may be related to prior participation in football.

Microglial neuroinflammation contributes to tau accumulation in chronic traumatic encephalopathy Open

Jonathan D. Cherry, Yorghos Tripodis, Victor E. Alvarez, Bertrand R. Huber, Patrick T. Kiernan , et al. · 2016

Cognitive Reserve as a Modifier of Clinical Expression in Chronic Traumatic Encephalopathy: A Preliminary Examination Open

Michael L. Alosco, Jesse Mez, Neil W. Kowall, Thor D. Stein, Lee E. Goldstein , et al. · 2016

This study conducted a preliminary examination on cognitive reserve (CR) as a modifier of symptom expression in subjects with autopsy-confirmed chronic traumatic encephalopathy (CTE). The sample included 25 former professional football pla…

Football Players' Perceptions of Future Risk of Concussion and Concussion-Related Health Outcomes Open

Christine M. Baugh, Emily Kroshus, Patrick T. Kiernan, David L. Mendel, William P. Meehan · 2016

Concussion is increasingly recognized as a risk of participation in contact and collision sports. There have been few examinations of athletes' perceptions of their susceptibility to concussion or concussion-related health consequences. We…

Assessing clinicopathological correlation in chronic traumatic encephalopathy: rationale and methods for the UNITE study Open

Jesse Mez, Todd M. Solomon, Daniel H. Daneshvar, Lauren Murphy, Patrick T. Kiernan , et al. · 2015

O5‐03‐06: The unite study: Understanding chronic traumatic encephalopathy through clinico‐pathological correlation — methods and instructive cases Open

Jesse Mez, Todd M. Solomon, Daniel H. Daneshvar, Philip H. Montenigro, Lauren Murphy , et al. · 2015

UNITE, a recently NIH-funded U01 examines the neuropathology and clinical presentation of brain donors “at risk” for chronic traumatic encephalopathy (CTE). We present methodology for examining clinicopathological correlation and two cases…

Beta-amyloid deposition in chronic traumatic encephalopathy Open

Thor D. Stein, Philip H. Montenigro, Victor E. Alvarez, Weiming Xia, John F. Crary , et al. · 2015

The Neuropathology of Chronic Traumatic Encephalopathy Open

Ann C. McKee, Thor D. Stein, Patrick T. Kiernan, Victor E. Alvarez · 2015

Repetitive brain trauma is associated with a progressive neurological deterioration, now termed as chronic traumatic encephalopathy ( CTE ). Most instances of CTE occur in association with the play of sports, but CTE has also been reported…

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