Patrick T.J. Hwang
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View article: Microglial pyroptosis drives neuropathic pain and targeting NLRP3 alleviates pain and neuroinflammation
Microglial pyroptosis drives neuropathic pain and targeting NLRP3 alleviates pain and neuroinflammation Open
Neuropathic pain is triggered by nerve damage or disease and involves chronic neuroinflammation driven by activated microglia releasing pro-inflammatory cytokines. PANoptosis, a complex cell death program encompassing apoptosis, pyroptosis…
View article: Full textile-based body-coupled electrical stimulation for wireless, battery-free, and wearable bioelectronics
Full textile-based body-coupled electrical stimulation for wireless, battery-free, and wearable bioelectronics Open
Electrical stimulation is effective for various therapeutic applications; however, to increase convenience, it is crucial to eliminate generators and batteries for wireless power transmission. This paper presents a full textile-based body-…
View article: Ultra‐High Peak Power Generation for Rotational Triboelectric Nanogenerator via Simple Charge Control and Boosted Discharge Design
Ultra‐High Peak Power Generation for Rotational Triboelectric Nanogenerator via Simple Charge Control and Boosted Discharge Design Open
Currently, enhancing the output power of rotational‐mode triboelectric nanogenerators (TENGs) using various complicated systems is a contentious issue; however, this is a challenging process owing to the inherent characteristics of TENGs, …
View article: Atherosclerotic three-layer nanomatrix vascular sheets for high-throughput therapeutic evaluation
Atherosclerotic three-layer nanomatrix vascular sheets for high-throughput therapeutic evaluation Open
In vitro atherosclerosis models are essential to evaluate therapeutics before in vivo and clinical studies, but significant limitations remain, such as the lack of three-layer vascular architecture and limited atherosclerotic features. Mor…
View article: A multi-targeting bionanomatrix coating to reduce capsular contracture development on silicone implants
A multi-targeting bionanomatrix coating to reduce capsular contracture development on silicone implants Open
Background Capsular contracture is a critical complication of silicone implantation caused by fibrotic tissue formation from excessive foreign body responses. Various approaches have been applied, but targeting the mechanisms of capsule fo…
View article: Pro-Healing Nanomatrix-Coated Stent Analysis in an <i>In Vitro</i> Vascular Double-Layer System and in a Rabbit Model
Pro-Healing Nanomatrix-Coated Stent Analysis in an <i>In Vitro</i> Vascular Double-Layer System and in a Rabbit Model Open
Cardiovascular stent technologies have significantly improved over time. However, their optimal performance remains limited by restenosis, thrombosis, inflammation, and delayed re-endothelialization. Current stent designs primarily target …
View article: Subcutaneous Administration of a Nitric Oxide-Releasing Nanomatrix Gel Ameliorates Obesity and Insulin Resistance in High-Fat Diet-Induced Obese Mice
Subcutaneous Administration of a Nitric Oxide-Releasing Nanomatrix Gel Ameliorates Obesity and Insulin Resistance in High-Fat Diet-Induced Obese Mice Open
Nitric oxide (NO) is a gaseous signaling molecule, which plays crucial roles in various biological processes, including inflammatory responses, metabolism, cardiovascular functions, and cognitive function. NO bioavailability is reduced wit…
View article: Lightweight mobile stick-type water-based triboelectric nanogenerator with amplified current for portable safety devices
Lightweight mobile stick-type water-based triboelectric nanogenerator with amplified current for portable safety devices Open
Due to its abundance, mechanical energy is a promising ambient energy source. Triboelectric nanogenerators (TENGs) represent an effective mechanical energy harvesting method based on the use of contact electrification. The existing liquid-…
View article: Lightweight mobile stick-type water-based triboelectric nanogenerator with amplified current for portable safety devices
Lightweight mobile stick-type water-based triboelectric nanogenerator with amplified current for portable safety devices Open
Due to its abundance, mechanical energy is a promising ambient energy source. Triboelectric nanogenerators (TENGs) represent an effective mechanical energy harvesting method based on the use of contact electrification. The existing liquid-…
View article: Endothelium-Mimicking Nanomatrix Coating to Enhance Endothelialization after Left Atrial Appendage Closure Device Implantation
Endothelium-Mimicking Nanomatrix Coating to Enhance Endothelialization after Left Atrial Appendage Closure Device Implantation Open
Blood clots (90%) originate from the left atrial appendage (LAA) in non-valvular atrial fibrillation patients and are a major cause of embolic stroke. Long-term anticoagulation therapy has been used to prevent thrombus formation, but its u…
View article: miRNA 146A-5P-Loaded Poly( <scp>D</scp> , <scp>L</scp> -Lactic-Co-Glycolic Acid) Nanoparticles Impair Pain Behaviors by Inhibiting Multiple Inflammatory Pathways in Microglia
miRNA 146A-5P-Loaded Poly( <span>D</span> , <span>L</span> -Lactic-Co-Glycolic Acid) Nanoparticles Impair Pain Behaviors by Inhibiting Multiple Inflammatory Pathways in Microglia Open
Aims: We investigated whether miRNA (miR) 146a-5p-loaded nanoparticles (NPs) can attenuate neuropathic pain behaviors in the rat spinal nerve ligation-induced neuropathic pain model by inhibiting activation of the NF-κB and p38 MAPK pathwa…
View article: Non-equilibrium organosilane plasma polymerization for modulating the surface of PTFE towards potential blood contact applications
Non-equilibrium organosilane plasma polymerization for modulating the surface of PTFE towards potential blood contact applications Open
We report a novel and facile organosilane plasma polymerization method designed to improve the surface characteristics of poly(tetrafluoroethylene) (PTFE).
View article: Encapsulation of Human Islets Using a Biomimetic Self-Assembled Nanomatrix Gel for Protection against Cellular Inflammatory Responses
Encapsulation of Human Islets Using a Biomimetic Self-Assembled Nanomatrix Gel for Protection against Cellular Inflammatory Responses Open
The major concern of pancreatic islet transplantation is that the implanted islets are exposed to the immune system of the recipient. To overcome this challenge, the peptide amphiphile (PA) nanomatrix gel was used for immunoisolation of is…
View article: Progress and challenges of the bioartificial pancreas
Progress and challenges of the bioartificial pancreas Open
Pancreatic islet transplantation has been validated as a treatment for type 1 diabetes since it maintains consistent and sustained type 1 diabetes reversal. However, one of the major challenges in pancreatic islet transplantation is the bo…
View article: Novel Multifunctional Nanomatrix Reduces Inflammation in Dynamic Conditions in Vitro and Dilates Arteries ex Vivo
Novel Multifunctional Nanomatrix Reduces Inflammation in Dynamic Conditions in Vitro and Dilates Arteries ex Vivo Open
Inflammatory responses play a critical role in tissue-implant interactions, often limiting current implant utility. This is particularly true for cardiovascular devices. Existing stent technology does little to avoid or mitigate inflammati…