Patrick Vilela
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View article: A Langendorff-heart discovery pipeline demonstrates cardiomyocyte targeting by extracellular vesicles functionalized with beta-blockers using click-chemistry
A Langendorff-heart discovery pipeline demonstrates cardiomyocyte targeting by extracellular vesicles functionalized with beta-blockers using click-chemistry Open
Extracellular vesicles (EVs) are widely explored as vehicles for delivering therapeutic or experimental cargo to cardiomyocytes. Efforts to improve EV bioavailability in the heart, and reduce their off-target actions, require screening met…
View article: The Colon Mucosal Sialylglycome Is Redox-Regulated by the Golgi Enzyme QSOX1
The Colon Mucosal Sialylglycome Is Redox-Regulated by the Golgi Enzyme QSOX1 Open
Mucus shields the intestinal epithelium from pathogens and provides a supportive environment for commensal bacteria. Mucus is composed of enormous, heavily glycosylated proteins called mucins, which become disulfide crosslinked in a multi-…
View article: Correction: Inhibition of fibroblast secreted QSOX1 perturbs extracellular matrix in the tumor microenvironment and decreases tumor growth and metastasis in murine cancer models
Correction: Inhibition of fibroblast secreted QSOX1 perturbs extracellular matrix in the tumor microenvironment and decreases tumor growth and metastasis in murine cancer models Open
[This corrects the article DOI: 10.18632/oncotarget.27438.].
View article: Inhibition of fibroblast secreted QSOX1 perturbs extracellular matrix in the tumor microenvironment and decreases tumor growth and metastasis in murine cancer models
Inhibition of fibroblast secreted QSOX1 perturbs extracellular matrix in the tumor microenvironment and decreases tumor growth and metastasis in murine cancer models Open
Extracellular matrix (ECM) plays an important role in tumor development and dissemination, but few points of therapeutic intervention targeting ECM of the tumor microenvironment have been exploited to date. Recent observations suggest that…
View article: Inorganic nanoparticle-oligonucleotide conjugates for bio-sensing and therapeutics
Inorganic nanoparticle-oligonucleotide conjugates for bio-sensing and therapeutics Open
In recent years, advances in conjugation techniques have allowed for the development of a vast range of hybrid materials nanomaterials with biomolecules. The use of hybrid nanomaterials has improved the imaging, treatment and diagnostics o…