Patrick J. Whelan
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View article: Restoration of locomotor function following stimulation of the A13 region in Parkinson’s mouse models
Restoration of locomotor function following stimulation of the A13 region in Parkinson’s mouse models Open
Parkinson’s disease (PD) is characterized by extensive motor and non-motor dysfunction, including gait disturbance, which is difficult to treat effectively. This study explores the therapeutic potential of targeting the A13 region, a heter…
View article: Restoration of locomotor function following stimulation of the A13 region in Parkinson’s mouse models
Restoration of locomotor function following stimulation of the A13 region in Parkinson’s mouse models Open
Parkinson’s disease (PD) is characterized by extensive motor and non-motor dysfunction, including gait disturbance, which is difficult to treat effectively. This study explores the therapeutic potential of targeting the A13 region, a heter…
View article: Restoration of locomotor function following stimulation of the A13 region in Parkinson’s mouse models
Restoration of locomotor function following stimulation of the A13 region in Parkinson’s mouse models Open
Parkinson’s disease (PD) is characterized by extensive motor and non-motor dysfunction, including gait disturbance, which is difficult to treat effectively. This study explores the therapeutic potential of targeting the A13 region, a heter…
View article: Deep brain stimulation of A13 region evokes robust locomotory response in rats
Deep brain stimulation of A13 region evokes robust locomotory response in rats Open
This study demonstrates that deep brain stimulation (DBS) of the A13 region in rats robustly increases locomotor activity without inducing anxiety using a novel wireless stimulation approach. This suggests A13 may be a promising therapeuti…
View article: Episodic rhythmicity is generated by a distributed neural network in the developing mammalian spinal cord
Episodic rhythmicity is generated by a distributed neural network in the developing mammalian spinal cord Open
Spinal circuits generate locomotor rhythms, but the mechanisms behind episodic locomotor behaviors remain unclear. This study investigated dopamine-induced episodic rhythms in isolated neonatal mouse spinal cords to understand these mechan…
View article: DISCOVERING TRANSLATIONAL BIOMARKERS IN NEURODEVELOPMENTAL CONDITIONS - EEG PROFILE IN MOUSE MODELS OF IDIOPATHIC AND SYNDROMIC AUTISM
DISCOVERING TRANSLATIONAL BIOMARKERS IN NEURODEVELOPMENTAL CONDITIONS - EEG PROFILE IN MOUSE MODELS OF IDIOPATHIC AND SYNDROMIC AUTISM Open
Background Autism is one of the most prevalent neurodevelopmental disorders worldwide. It is predominantly idiopathic, while syndromic forms have also been identified. Fragile X Syndrome (FXS) is the most common monogenic cause of autism a…
View article: Episodic rhythmicity is generated by a distributed neural network in the developing mammalian spinal cord
Episodic rhythmicity is generated by a distributed neural network in the developing mammalian spinal cord Open
Summary Spinal circuits produce diverse motor outputs that coordinate the rhythm and pattern of locomotor movements. Despite the episodic nature of these behaviours, the neural mechanisms encoding these episodes are not well understood. Th…
View article: Reviewer #2 (Public Review): Restoration of locomotor function following stimulation of the A13 region in Parkinson’s mouse models
Reviewer #2 (Public Review): Restoration of locomotor function following stimulation of the A13 region in Parkinson’s mouse models Open
Parkinson’s disease (PD) is characterized by extensive motor and non-motor dysfunction, including gait disturbance, which is difficult to treat effectively. This study explores the therapeutic potential of targeting the A13 region, a dopam…
View article: Reviewer #1 (Public Review): Restoration of locomotor function following stimulation of the A13 region in Parkinson’s mouse models
Reviewer #1 (Public Review): Restoration of locomotor function following stimulation of the A13 region in Parkinson’s mouse models Open
Parkinson’s disease (PD) is characterized by extensive motor and non-motor dysfunction, including gait disturbance, which is difficult to treat effectively. This study explores the therapeutic potential of targeting the A13 region, a dopam…
View article: Restoration of locomotor function following stimulation of the A13 region in Parkinson’s mouse models
Restoration of locomotor function following stimulation of the A13 region in Parkinson’s mouse models Open
Parkinson’s disease (PD) is characterized by extensive motor and non-motor dysfunction, including gait disturbance, which is difficult to treat effectively. This study explores the therapeutic potential of targeting the A13 region, a heter…
View article: Restoration of locomotor function following stimulation of the A13 region in Parkinson’s mouse models
Restoration of locomotor function following stimulation of the A13 region in Parkinson’s mouse models Open
Parkinson’s disease (PD) is characterized by extensive motor and non-motor dysfunction, including gait disturbance, which is difficult to treat effectively. This study explores the therapeutic potential of targeting the A13 region, a dopam…
View article: Author Response: Restoration of locomotor function following stimulation of the A13 region in Parkinson’s mouse models
Author Response: Restoration of locomotor function following stimulation of the A13 region in Parkinson’s mouse models Open
Parkinson’s disease (PD) is characterized by extensive motor and non-motor dysfunction, including gait disturbance, which is difficult to treat effectively. This study explores the therapeutic potential of targeting the A13 region, a dopam…
View article: Mapping nanoscale carrier confinement in polycrystalline graphene by terahertz spectroscopy
Mapping nanoscale carrier confinement in polycrystalline graphene by terahertz spectroscopy Open
Terahertz time-domain spectroscopy (THz-TDS) can be used to map spatial variations in electrical properties such as sheet conductivity, carrier density, and carrier mobility in graphene. Here, we consider wafer-scale graphene grown on germ…
View article: Restoration of locomotor function following stimulation of the A13 region in Parkinson’s mouse models
Restoration of locomotor function following stimulation of the A13 region in Parkinson’s mouse models Open
Parkinson’s disease (PD) is characterized by extensive motor and non-motor dysfunction, including gait disturbance, which is difficult to treat effectively. This study explores the therapeutic potential of targeting the A13 region, a heter…
View article: Dataset and additional info for "Serious adverse events of special interest following mRNA vaccination in randomized trials" (Fraiman et al. 2022)
Dataset and additional info for "Serious adverse events of special interest following mRNA vaccination in randomized trials" (Fraiman et al. 2022) Open
Dataset for: Fraiman J, Erviti J, Jones M, Greenland S, Whelan P, Kaplan RM, Doshi P. Serious adverse events of special interest following mRNA COVID-19 vaccination in randomized trials in adults. Vaccine. 2022 Aug 30;40(40):5798–805. doi:…
View article: Dataset and additional info for "Serious adverse events of special interest following mRNA vaccination in randomized trials" (Fraiman et al. 2022)
Dataset and additional info for "Serious adverse events of special interest following mRNA vaccination in randomized trials" (Fraiman et al. 2022) Open
Dataset for: Fraiman J, Erviti J, Jones M, Greenland S, Whelan P, Kaplan RM, Doshi P. Serious adverse events of special interest following mRNA COVID-19 vaccination in randomized trials in adults. Vaccine. 2022 Aug 30;40(40):5798–805. doi:…
View article: The Mesencephalic Locomotor Region: Beyond Locomotor Control
The Mesencephalic Locomotor Region: Beyond Locomotor Control Open
The mesencephalic locomotor region (MLR) was discovered several decades ago in the cat. It was functionally defined based on the ability of low threshold electrical stimuli within a region comprising the cuneiform and pedunculopontine nucl…
View article: Serious adverse events of special interest following mRNA vaccination in randomized trials
Serious adverse events of special interest following mRNA vaccination in randomized trials Open
Self-published preprint being put on Zenodo for archival purposes: "Serious adverse events of special interest following mRNA vaccination in randomized trials", 25 Feb 2022
View article: <i>Hop</i> Mice Display Synchronous Hindlimb Locomotion and a Ventrally Fused Lumbar Spinal Cord Caused by a Point Mutation in <i>Ttc26</i>
<i>Hop</i> Mice Display Synchronous Hindlimb Locomotion and a Ventrally Fused Lumbar Spinal Cord Caused by a Point Mutation in <i>Ttc26</i> Open
Identifying the spinal circuits controlling locomotion is critical for unravelling the mechanisms controlling the production of gaits. Development of the circuits governing left-right coordination relies on axon guidance molecules such as …
View article: Contributions of h- and Na+/K+ Pump Currents to the Generation of Episodic and Continuous Rhythmic Activities
Contributions of h- and Na+/K+ Pump Currents to the Generation of Episodic and Continuous Rhythmic Activities Open
Developing spinal motor networks produce a diverse array of outputs, including episodic and continuous patterns of rhythmic activity. Variation in excitability state and neuromodulatory tone can facilitate transitions between episodic and …
View article: Contributions of h- and Na<sup>+</sup>/K<sup>+</sup>pump currents to the generation of episodic and continuous rhythmic activities
Contributions of h- and Na<sup>+</sup>/K<sup>+</sup>pump currents to the generation of episodic and continuous rhythmic activities Open
Developing spinal motor networks produce a diverse array of outputs, including episodic and continuous patterns of rhythmic activity. Variation in excitability state and neuromodulatory tone can facilitate transitions between episodic and …
View article: The Effects of a Ketogenic Diet on Sensorimotor Function in a Thoracolumbar Mouse Spinal Cord Injury Model
The Effects of a Ketogenic Diet on Sensorimotor Function in a Thoracolumbar Mouse Spinal Cord Injury Model Open
Spinal cord injury and peripheral nerve injuries are traumatic events that greatly impact quality of life. One factor that is being explored throughout patient care is the idea of diet and the role it has on patient outcomes. But the effec…
View article: Fiber photometry for monitoring cerebral oxygen saturation in freely-moving rodents
Fiber photometry for monitoring cerebral oxygen saturation in freely-moving rodents Open
Hemodynamic parameters, such as tissue oxygen saturation and blood volume fraction, are important markers of brain physiology. They are also widely used surrogate markers of electrophysiological activity. Here, we present a single fiber sp…
View article: A point mutation in<i>Ttc26</i>causes lumbar spinal cord fusion and synchronous hind-limb locomotion in<i>hop</i>mice
A point mutation in<i>Ttc26</i>causes lumbar spinal cord fusion and synchronous hind-limb locomotion in<i>hop</i>mice Open
Identifying the spinal circuits controlling locomotion is critical for unravelling the mechanisms controlling the production of gaits. Development of the circuits governing left-right coordination relies on axon guidance molecules such as …
View article: A dynamic role for dopamine receptors in the control of mammalian spinal networks
A dynamic role for dopamine receptors in the control of mammalian spinal networks Open
Dopamine is well known to regulate movement through the differential control of direct and indirect pathways in the striatum that express D 1 and D 2 receptors respectively. The spinal cord also expresses all dopamine receptors however; ho…
View article: A supervised machine learning approach to characterize spinal network function
A supervised machine learning approach to characterize spinal network function Open
Spontaneous activity is a common feature of immature neuronal networks throughout the central nervous system and plays an important role in network development and consolidation. In postnatal rodents, spontaneous activity in the spinal cor…