Patrick Wurzel
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View article: Cellular landscape of reactive and neoplastic human lymph nodes in 3D
Cellular landscape of reactive and neoplastic human lymph nodes in 3D Open
Lymph nodes function according to cellular and structural regulations. When these rules deviate from the benign equilibrium, dysregulations occur leading to the onset of diseases. In the development of malignant lymph node diseases, proces…
View article: Deletion of ABIN1-LIR motifs impairs hepatic lipid homeostasis and mitophagy via AMPK-TFEB axis in mice
Deletion of ABIN1-LIR motifs impairs hepatic lipid homeostasis and mitophagy via AMPK-TFEB axis in mice Open
Having identified LC3-interacting region (LIR) motifs 1/2 of A20 binding inhibitor of NF-κB-1 (ABIN-1) as mitophagy regulators in vitro, this study generated CRISPR-engineered ABIN1-ΔLIR1/2 mice lacking both LIR motifs to elucidate its in …
View article: Behavioral investigation of reactive and neoplastic lymphocytes in human lymph nodes in 4D
Behavioral investigation of reactive and neoplastic lymphocytes in human lymph nodes in 4D Open
This study deals with a 4D investigation of lymphocytes in human tissue under reactive and neoplastic conditions. The immune system’s response to pathogens highly depends on cell interaction and movement, which makes it essential to analyz…
View article: Lymphomas in 3D and 4D spaces
Lymphomas in 3D and 4D spaces Open
The cellular compartments in the lymph node form dynamic networks, enabling coordinated innate and adaptive immunological responses. This compartmentalization of the lymph node into subcompartments, such as the T and B zones, has been prov…
View article: Computational systems biology of cellular processes in the human lymph node
Computational systems biology of cellular processes in the human lymph node Open
The human immune system is determined by the functionality of the human lymph node. With the use of high-throughput techniques in clinical diagnostics, a large number of data is currently collected. The new data on the spatiotemporal organ…
View article: Holistic View on the Structure of Immune Response: Petri Net Model
Holistic View on the Structure of Immune Response: Petri Net Model Open
The simulation of immune response is a challenging task because quantitative data are scarce. Quantitative theoretical models either focus on specific cell–cell interactions or have to make assumptions about parameters. The broad variation…
View article: The E3 Ligase TRIM25 Impairs Apoptotic Cell Death in Colon Carcinoma Cells via Destabilization of Caspase-7 mRNA: A Possible Role of hnRNPH1
The E3 Ligase TRIM25 Impairs Apoptotic Cell Death in Colon Carcinoma Cells via Destabilization of Caspase-7 mRNA: A Possible Role of hnRNPH1 Open
Therapy resistance is still a major reason for treatment failure in colorectal cancer (CRC). Previously, we identified the E3 ubiquitin ligase TRIM25 as a novel suppressor of caspase-2 translation which contributes to the apoptosis resista…
View article: Imaging bridges pathology and radiology
Imaging bridges pathology and radiology Open
In recent years, medical disciplines have moved closer together and rigid borders have been increasingly dissolved. The synergetic advantage of combining multiple disciplines is particularly important for radiology, nuclear medicine, and p…
View article: Lymphocyte movement in human adenoids
Lymphocyte movement in human adenoids Open
The dataset includes videos of fresh adenoid tissue slices of 10 patiens. Each file is anonymised and cannot be traced back to an individual persons. Each patient gave his informed consent in accordance with the Declaration of Helsinki. Co…
View article: Lymphocyte movement in human adenoids
Lymphocyte movement in human adenoids Open
The dataset includes videos of fresh adenoid tissue slices of 10 patiens. Each file is anonymised and cannot be traced back to an individual persons. Each patient gave his informed consent in accordance with the Declaration of Helsinki. Co…
View article: Detection of follicular regions in actin-stained whole slide images of the human lymph node by shock filter
Detection of follicular regions in actin-stained whole slide images of the human lymph node by shock filter Open
Human lymph nodes play a central part of immune defense against infection agents and tumor cells. Lymphoid follicles are compartments of the lymph node which are spherical, mainly filled with B cells. B cells are cellular components of the…
View article: 3D investigation shows walls and wall-like structures around human germinal centres, probably regulating T- and B-cell entry and exit
3D investigation shows walls and wall-like structures around human germinal centres, probably regulating T- and B-cell entry and exit Open
This study deals with 3D laser investigation on the border between the human lymph node T-zone and germinal centre. Only a few T-cells specific for antigen selected B-cells are allowed to enter germinal centres. This selection process is g…
View article: 3D image analysis reveals differences of CD30 positive cells and network formation in reactive and malignant human lymphoid tissue (classical Hodgkin Lymphoma)
3D image analysis reveals differences of CD30 positive cells and network formation in reactive and malignant human lymphoid tissue (classical Hodgkin Lymphoma) Open
In contrast to 2D histology, 3D laser scanning offers a visualisation of complete cells, their network interaction and spatial distribution in the tissue. The possibility to differentiate cells in regards to volume, surface, shape, and clu…