Patrik Wernhoff
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View article: Characterization of Screening Strategies for Lynch Syndrome in Latin America
Characterization of Screening Strategies for Lynch Syndrome in Latin America Open
View article: CD37 is a safe chimeric antigen receptor target to treat acute myeloid leukemia
CD37 is a safe chimeric antigen receptor target to treat acute myeloid leukemia Open
View article: ALPL-1 is a target for chimeric antigen receptor therapy in osteosarcoma
ALPL-1 is a target for chimeric antigen receptor therapy in osteosarcoma Open
View article: Genetic Characterization in High-Risk Individuals from a Low-Resource City of Peru
Genetic Characterization in High-Risk Individuals from a Low-Resource City of Peru Open
Background: Genetic testing for hereditary cancers is inconsistently applied within the healthcare systems in Latin America. In Peru, the prevalence and spectrum of cancer-predisposing germline variants is thus poorly characterized. Purpos…
View article: A phase I/II escalation trial design T-RAD: Treatment of metastatic lung cancer with mRNA-engineered T cells expressing a T cell receptor targeting human telomerase reverse transcriptase (hTERT)
A phase I/II escalation trial design T-RAD: Treatment of metastatic lung cancer with mRNA-engineered T cells expressing a T cell receptor targeting human telomerase reverse transcriptase (hTERT) Open
Background Adoptive cellular therapy (ACT) with genetically modified T cells aims to redirect T cells against resistant cancers through introduction of a T cell receptor (TCR). The Radium-4 TCR was isolated from a responding patient in a c…
View article: Challenges to Bringing Personalized Medicine to a Low-Resource Setting in Peru
Challenges to Bringing Personalized Medicine to a Low-Resource Setting in Peru Open
We provide an overview of the challenges that low-resource setting cities are facing, including a lack of global implementation of cancer screening programs, accurate data and statistics that may aid the health authorities and guide future…
View article: Dysregulation of MITF Leads to Transformation in MC1R-Defective Melanocytes
Dysregulation of MITF Leads to Transformation in MC1R-Defective Melanocytes Open
The MC1R/cAMP/MITF pathway is a key determinant for growth, differentiation, and survival of melanocytes and melanoma. MITF-M is the melanocyte-specific isoform of Microphthalmia-associated Transcription Factor (MITF) in human melanoma. He…
View article: Soluble AXL as a marker of disease progression and survival in melanoma
Soluble AXL as a marker of disease progression and survival in melanoma Open
Receptor tyrosine kinase AXL is a one-pass transmembrane protein upregulated in cancers and associated with lower survival and therapy resistance. AXL can be cleaved by the A Disintegrin and Metalloproteinases (ADAM)10 and ADAM17, yielding…
View article: MX 2 is a novel regulator of cell cycle in melanoma cells
MX 2 is a novel regulator of cell cycle in melanoma cells Open
MX2 protein is a dynamin‐like GTPase2 that has recently been identified as an interferon‐induced restriction factor of HIV‐1 and other primate lentiviruses. A single nucleotide polymorphism (SNP), rs45430, in an intron of the MX2 gene, was…
View article: Abstract 1049A: Deregulation of MITF in the context of inactive MC1R leads to melanocyte transformation
Abstract 1049A: Deregulation of MITF in the context of inactive MC1R leads to melanocyte transformation Open
MC1R, the cAMP pathway and the response to solar UV are all elements involved in the growth, differentiation and survival of melanocytes and in malignant melanoma. Here we present a model of melanomagenesis based on the forced expression o…
View article: From colorectal cancer pattern to the characterization of individuals at risk: picture for genetic research in Latin America
From colorectal cancer pattern to the characterization of individuals at risk: picture for genetic research in Latin America Open
Colorectal cancer (CRC) is one of the most common cancers in Latin America and the Caribbean, with the highest rates reported for Uruguay, Brazil and Argentina. We provide a global snapshot of the CRC patterns, how screening is performed, …
View article: A Three-dimensional Ex Vivo Viability Assay Reveals a Strong Correlation Between Response to Targeted Inhibitors and Mutation Status in Melanoma Lymph Node Metastases
A Three-dimensional Ex Vivo Viability Assay Reveals a Strong Correlation Between Response to Targeted Inhibitors and Mutation Status in Melanoma Lymph Node Metastases Open
View article: From colorectal cancer pattern to the characterization of individuals at risk: Picture for genetic research in Latin America
From colorectal cancer pattern to the characterization of individuals at risk: Picture for genetic research in Latin America Open
Colorectal cancer (CRC) is one of the most common cancers in Latin America and the Caribbean, with the highest rates reported for Uruguay, Brazil and Argentina. We provide a global snapshot of the CRC patterns, how screening is performed, …
View article: A survey of the clinicopathological and molecular characteristics of patients with suspected Lynch syndrome in Latin America
A survey of the clinicopathological and molecular characteristics of patients with suspected Lynch syndrome in Latin America Open
The Latin America LS pathogenic MMR variants spectrum included new variants, frequently altered genetic regions and potential founder effects, emphasizing the relevance implementing Lynch syndrome genetic testing and counseling in all of L…
View article: Update on Hereditary Colorectal Cancer
Update on Hereditary Colorectal Cancer Open
In the past two decades, significant advances have been made in our understanding of colorectal (CRC) tumors with DNA mismatch (MMR) repair deficiency. The knowledge from molecular and genetic alterations in a variety of clinical condition…
View article: MLH1 Ile219Val Polymorphism in Argentinean Families with Suspected Lynch Syndrome
MLH1 Ile219Val Polymorphism in Argentinean Families with Suspected Lynch Syndrome Open
DATA REPORT article Front. Oncol., 24 August 2016Sec. Gastrointestinal Cancers Volume 6 - 2016 | https://doi.org/10.3389/fonc.2016.00189