Patrizia Marchese
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View article: Unique Pathway of Thrombin-induced Platelet Aggregation Mediated by Glycoprotein Ib
Unique Pathway of Thrombin-induced Platelet Aggregation Mediated by Glycoprotein Ib Open
Thrombin plays a central role in normal and abnormal hemostatic processes. It is assumed that alpha-thrombin activates platelets by hydrolyzing the protease-activated receptor (PAR)-1, thereby exposing a new N-terminal sequence, a tethered…
View article: Confocal Blood Flow Videomicroscopy of Thrombus Formation over Human Arteries and Local Targeting of P2X7
Confocal Blood Flow Videomicroscopy of Thrombus Formation over Human Arteries and Local Targeting of P2X7 Open
Atherothrombosis exposes vascular components to blood. Currently, new antithrombotic therapies are emerging. Herein we investigated thrombogenesis of human arteries with/without atherosclerosis, and the interaction of coagulation and vascu…
View article: Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis
Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis Open
View article: Selective factor VIII activation by the tissue factor–factor VIIa–factor Xa complex
Selective factor VIII activation by the tissue factor–factor VIIa–factor Xa complex Open
Publisher's Note: There is an Inside Blood Commentary on this article in this issue.
View article: Tissue Factor Prothrombotic Activity Is Regulated by Integrin-arf6 Trafficking
Tissue Factor Prothrombotic Activity Is Regulated by Integrin-arf6 Trafficking Open
Objective— Coagulation initiation by tissue factor (TF) is regulated by cellular inhibitors, cell surface availability of procoagulant phosphatidylserine, and thiol-disulfide exchange. How these mechanisms contribute to keeping TF in a non…
View article: Prothrombotic skeletal muscle myosin directly enhances prothrombin activation by binding factors Xa and Va
Prothrombotic skeletal muscle myosin directly enhances prothrombin activation by binding factors Xa and Va Open
Key Points Skeletal muscle myosin promotes thrombus formation and enhances prothrombin activation by binding factors Xa and Va. The procoagulant activity of skeletal muscle myosin might contribute to the hypercoagulability in plasmas of ac…
View article: Activated tumor cell integrin αvβ3 cooperates with platelets to promote extravasation and metastasis from the blood stream
Activated tumor cell integrin αvβ3 cooperates with platelets to promote extravasation and metastasis from the blood stream Open
View article: Caspase-1–mediated pathway promotes generation of thromboinflammatory microparticles
Caspase-1–mediated pathway promotes generation of thromboinflammatory microparticles Open
Extracellular ATP is a signal of tissue damage and induces macrophage responses that amplify inflammation and coagulation. Here we demonstrate that ATP signaling through macrophage P2X7 receptors uncouples the thioredoxin (TRX)/TRX reducta…