Patrizia Pignataro
YOU?
Author Swipe
View article: Association Between Decision-Making Styles, Personality Traits, and Socio-Demographic Factors in Women Choosing Voluntary Pregnancy Termination: A Cross-Sectional Study
Association Between Decision-Making Styles, Personality Traits, and Socio-Demographic Factors in Women Choosing Voluntary Pregnancy Termination: A Cross-Sectional Study Open
Personality traits, decision-making styles, and socio-demographic information help understand the characteristics of women requesting voluntary termination of pregnancy (VTP) and monitor the timing and quality of this service However, our …
View article: Correlation Between Irisin and Cognitive Functions in Alzheimer Dementia
Correlation Between Irisin and Cognitive Functions in Alzheimer Dementia Open
Objective The myokine irisin, a recent positive mediator of exercise in the brain, shows neuroprotective functions against Alzheimer's disease (AD). The association between irisin and cognition has never been explored in a biologically def…
View article: Issue Information
Issue Information Open
HINARI, AGORA, and OARE initiatives.They are now collectively known as Research4Life, making online scientific content available free or at nominal cost to researchers in developing countries and enabling more researchers to publish open a…
View article: Irisin prevents trabecular bone damage and tumor invasion in a mouse model of multiple myeloma
Irisin prevents trabecular bone damage and tumor invasion in a mouse model of multiple myeloma Open
Bone disease associated with multiple myeloma (MM) is characterized by osteolytic lesions and pathological fractures, which remain a therapeutic priority despite new drugs improving MM patient survival. Antiresorptive molecules represent t…
View article: Irisin Levels in Cerebrospinal Fluid Correlate with Biomarkers and Clinical Dementia Scores in Alzheimer Disease
Irisin Levels in Cerebrospinal Fluid Correlate with Biomarkers and Clinical Dementia Scores in Alzheimer Disease Open
Objective Irisin, released by muscles during exercise, was recently identified as a neuroprotective factor in mouse models of Alzheimer disease (AD). In a cohort of AD patients, we studied cerebrospinal fluid (CSF) and plasma irisin levels…
View article: Irisin Treatment Prevents Isoproterenol-Induced Cardiac Fibrosis in Mice
Irisin Treatment Prevents Isoproterenol-Induced Cardiac Fibrosis in Mice Open
Our results demonstrate the beneficial effect of irisin in preventing isoproterenol-induced cardiac hypertrophy and fibrosis.
View article: Irisin Protects against Loss of Trabecular Bone Mass and Strength in Adult Ovariectomized Mice by Stimulating Osteoblast Activity
Irisin Protects against Loss of Trabecular Bone Mass and Strength in Adult Ovariectomized Mice by Stimulating Osteoblast Activity Open
Irisin is a peptide secreted by skeletal muscle that plays a major role in bone metabolism. Experiments in mouse models have shown that administration of recombinant irisin prevents disuse-induced bone loss. In this study, we aimed to eval…
View article: Short-Term Irisin Treatment Enhanced Neurotrophin Expression Differently in the Hippocampus and the Prefrontal Cortex of Young Mice
Short-Term Irisin Treatment Enhanced Neurotrophin Expression Differently in the Hippocampus and the Prefrontal Cortex of Young Mice Open
As a result of physical exercise, muscle releases multiple exerkines, such as “irisin”, which is thought to induce pro-cognitive and antidepressant effects. We recently demonstrated in young healthy mice the mitigation of depressive behavi…
View article: Once-Daily Subcutaneous Irisin Administration Mitigates Depression- and Anxiety-like Behavior in Young Mice
Once-Daily Subcutaneous Irisin Administration Mitigates Depression- and Anxiety-like Behavior in Young Mice Open
Major depression is one of the most common psychiatric disorders worldwide, usually associated with anxiety. The multi-etiological nature of depression has increased the search for new antidepressant molecules, including irisin, for which,…
View article: Vitamin D Increases Irisin Serum Levels and the Expression of Its Precursor in Skeletal Muscle
Vitamin D Increases Irisin Serum Levels and the Expression of Its Precursor in Skeletal Muscle Open
Irisin is a myokine synthesized by skeletal muscle, which performs key actions on whole-body metabolism. Previous studies have hypothesized a relationship between irisin and vitamin D, but the pathway has not been thoroughly investigated. …
View article: Elevated Expression of ADAM10 in Skeletal Muscle of Patients with Idiopathic Inflammatory Myopathies Could Be Responsible for FNDC5/Irisin Unbalance
Elevated Expression of ADAM10 in Skeletal Muscle of Patients with Idiopathic Inflammatory Myopathies Could Be Responsible for FNDC5/Irisin Unbalance Open
Dermatomyositis (DM) and immune-mediated necrotizing myopathy (IMNM) are two rare diseases belonging to the group of idiopathic inflammatory myopathies (IIM). Muscle involvement in DM is characterized by perifascicular atrophy and poor myo…
View article: Time-dependent unloading effects on muscle and bone and involvement of FNDC5/irisin axis
Time-dependent unloading effects on muscle and bone and involvement of FNDC5/irisin axis Open
The identification of biomarkers and countermeasures to prevent the adverse effects on the musculoskeletal system caused by the absence of mechanical loading is the main goal of space biomedical research studies. In this study, we analyzed…
View article: Impact of 10‐day bed rest on serum levels of irisin and markers of musculoskeletal metabolism
Impact of 10‐day bed rest on serum levels of irisin and markers of musculoskeletal metabolism Open
The bed rest (BR) is a ground‐based model to simulate microgravity mimicking skeletal‐muscle alterations as in spaceflight. Molecular coupling between bone and muscle might be involved in physiological and pathological conditions. Thus, th…
View article: Circulating Irisin Levels in Patients with Chronic Plaque Psoriasis
Circulating Irisin Levels in Patients with Chronic Plaque Psoriasis Open
Irisin is an adipo-myokine, mainly synthetized in skeletal muscles and adipose tissues, that is involved in multiple processes. Only a few studies have evaluated serum irisin in psoriatic patients. This study aims to analyze serum irisin l…
View article: Antidepressant Effect of Intermittent Long-Term Systemic Administration of Irisin in Mice
Antidepressant Effect of Intermittent Long-Term Systemic Administration of Irisin in Mice Open
Depression is a psychiatric disorder increasingly diffused worldwide. Evidence suggests that irisin, a myokine secreted by contracting muscle, mediates beneficial effects on several targets, including the brain. Here, the potential antidep…
View article: Irisin Serum Levels and Skeletal Muscle Assessment in a Cohort of Charcot-Marie-Tooth Patients
Irisin Serum Levels and Skeletal Muscle Assessment in a Cohort of Charcot-Marie-Tooth Patients Open
Background Charcot-Marie-Tooth (CMT) indicates a group of inherited polyneuropathies whose clinical phenotypes primarily include progressive distal weakness and muscle atrophy. Compelling evidence showed that the exercise-mimetic myokine i…
View article: Irisin is a potential biomarker to predict muscular atrophy and bone loss progression in Charcot-Marie-Tooth Patients
Irisin is a potential biomarker to predict muscular atrophy and bone loss progression in Charcot-Marie-Tooth Patients Open
View article: Evaluation of serum concentration of Irisin and molecules affecting the musculoskeletal system after 10-day Bed Rest
Evaluation of serum concentration of Irisin and molecules affecting the musculoskeletal system after 10-day Bed Rest Open
View article: Irisin and Secondary Osteoporosis in Humans
Irisin and Secondary Osteoporosis in Humans Open
Irisin is a peptide secreted by skeletal muscle following exercise that plays an important role in bone metabolism. Numerous experiments in vitro and in mouse models have shown that the administration of recombinant irisin promotes osteoge…
View article: The Novel Role of PGC1α in Bone Metabolism
The Novel Role of PGC1α in Bone Metabolism Open
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) is a protein that promotes transcription of numerous genes, particularly those responsible for the regulation of mitochondrial biogenesis. Evidence for a key role…
View article: Involvement of Irisin in age-related osteoporosis: positive correlation with BMD in older adult patients and inhibitory effect on the senescent marker p21 in osteoblasts
Involvement of Irisin in age-related osteoporosis: positive correlation with BMD in older adult patients and inhibitory effect on the senescent marker p21 in osteoblasts Open
View article: FNDC5/Irisin System in Neuroinflammation and Neurodegenerative Diseases: Update and Novel Perspective
FNDC5/Irisin System in Neuroinflammation and Neurodegenerative Diseases: Update and Novel Perspective Open
Irisin, the circulating peptide originating from fibronectin type III domain-containing protein 5 (FNDC5), is mainly expressed by muscle fibers under peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) control duri…
View article: In Reply to the Letter to the Editor: Involvement of Irisin in Age-Related Osteoporosis and Its Inhibitory Effect on the Senescent Marker p21 in Osteoblasts
In Reply to the Letter to the Editor: Involvement of Irisin in Age-Related Osteoporosis and Its Inhibitory Effect on the Senescent Marker p21 in Osteoblasts Open
We appreciate the thoughtful letter from Professor Naharciregarding our recently published article showing that iri-sin correlates positively with bone mineral density (BMD) in acohort of older adult patients and downregulates the senescen…
View article: Irisin Correlates Positively With BMD in a Cohort of Older Adult Patients and Downregulates the Senescent Marker p21 in Osteoblasts
Irisin Correlates Positively With BMD in a Cohort of Older Adult Patients and Downregulates the Senescent Marker p21 in Osteoblasts Open
Irisin is a myokine produced by skeletal muscle during exercise in both mice and humans. We previously showed that irisin treatment ameliorates immobility-induced osteoporosis and muscular atrophy in mice. Data in humans showed a positive …
View article: Irisin serum levels are positively correlated with bone mineral status in a population of healthy children
Irisin serum levels are positively correlated with bone mineral status in a population of healthy children Open
View article: A Polygenic Risk Score of glutamatergic SNPs associated with schizophrenia predicts attentional behavior and related brain activity in healthy humans
A Polygenic Risk Score of glutamatergic SNPs associated with schizophrenia predicts attentional behavior and related brain activity in healthy humans Open