Pau Biak Sang
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View article: Human CST complex restricts excessive PrimPol repriming upon UV induced replication stress by suppressing p21
Human CST complex restricts excessive PrimPol repriming upon UV induced replication stress by suppressing p21 Open
DNA replication stress, caused by various endogenous and exogenous agents, halt or stall DNA replication progression. Cells have developed diverse mechanisms to tolerate and overcome replication stress, enabling them to continue replicatio…
View article: A predictable conserved DNA base composition signature defines human core DNA replication origins
A predictable conserved DNA base composition signature defines human core DNA replication origins Open
DNA replication initiates from multiple genomic locations called replication origins. In metazoa, DNA sequence elements involved in origin specification remain elusive. Here, we examine pluripotent, primary, differentiating, and immortaliz…
View article: Roles of OB-Fold Proteins in Replication Stress
Roles of OB-Fold Proteins in Replication Stress Open
Accurate DNA replication is essential for maintaining genome stability. However, this stability becomes vulnerable when replication fork progression is stalled or slowed - a condition known as replication stress. Prolonged fork stalling ca…
View article: Actin R256 Mono-methylation Is a Conserved Post-translational Modification Involved in Transcription
Actin R256 Mono-methylation Is a Conserved Post-translational Modification Involved in Transcription Open
Nuclear actin has been elusive due to the lack of knowledge about molecular mechanisms. From actin-containing chromatin remodeling complexes, we discovered an arginine mono-methylation mark on an evolutionarily conserved R256 residue of ac…
View article: Structural studies on <i>M. smegmatis</i> MutT2, a sanitization enzyme
Structural studies on <i>M. smegmatis</i> MutT2, a sanitization enzyme Open
Incorporation in DNA of oxidized or damaged nucleotides, such as 8-oxo-dGTP or 5-me-dCTP generated during cellular metabolism or as a response to stress in the host cell, is detrimental to genomic integrity.Apart from a plethora of DNA rep…