Paul Bangirana
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View article: Association between early alcohol use and academic achievement among primary school children in Uganda: a cross-sectional study
Association between early alcohol use and academic achievement among primary school children in Uganda: a cross-sectional study Open
View article: Supplemental choline to prevent and treat learning and memory deficits of early-life iron deficiency (The SupCHO Study): study protocol for a randomized, placebo-controlled trial in Ugandan infants with iron deficiency anemia
Supplemental choline to prevent and treat learning and memory deficits of early-life iron deficiency (The SupCHO Study): study protocol for a randomized, placebo-controlled trial in Ugandan infants with iron deficiency anemia Open
Background: Iron deficiency (ID) limits the neurodevelopmental potential of more than 200 million children each year. Iron therapy started when IDA is first diagnosed—typically by screening for anemia at or detection of clinical symptoms o…
View article: Malaria associated pathogenesis of chronic kidney disease (MAP-CKD): a prospective study of children hospitalized with severe malaria
Malaria associated pathogenesis of chronic kidney disease (MAP-CKD): a prospective study of children hospitalized with severe malaria Open
View article: Predictors of trajectories of child neurodevelopment in the first 2 years of life in LMICs: A systematic review and meta-analysis protocol.
Predictors of trajectories of child neurodevelopment in the first 2 years of life in LMICs: A systematic review and meta-analysis protocol. Open
View article: Academic Proficiency in Ugandan Children With Sickle Cell Anemia: A Cross‐Sectional Study
Academic Proficiency in Ugandan Children With Sickle Cell Anemia: A Cross‐Sectional Study Open
Introduction Academic proficiency is crucial for advancing learning goals, school advancement, and future economic security. Children with sickle cell anemia (SCA) in sub‐Saharan Africa (SSA) may be at risk of disease‐associated learning d…
View article: Neurocognitive gains among Ugandan children with sickle cell anemia on hydroxyurea: 18-month interim trial results
Neurocognitive gains among Ugandan children with sickle cell anemia on hydroxyurea: 18-month interim trial results Open
Children with sickle cell anemia (SCA) frequently develop progressive neurocognitive impairment. We aimed to determine effects of hydroxyurea therapy on neurocognitive function in Ugandan children with SCA by comparing levels at enrollment…
View article: Cytomegalovirus reactivation and acute and chronic complications in children with cerebral malaria: a prospective cohort study
Cytomegalovirus reactivation and acute and chronic complications in children with cerebral malaria: a prospective cohort study Open
In children with cerebral malaria, CMV DNAemia is associated with acute kidney injury but not in-hospital mortality, chronic kidney disease, or long-term neurocognitive impairment.
View article: Severe Malarial Anaemia in Childhood is Associated with Decreased Long-Term Household Wealth
Severe Malarial Anaemia in Childhood is Associated with Decreased Long-Term Household Wealth Open
View article: Association of COVID-19-related perceptions and experiences with depression and anxiety in Ugandan caregivers of young children with malaria and iron deficiency: A cross-sectional study
Association of COVID-19-related perceptions and experiences with depression and anxiety in Ugandan caregivers of young children with malaria and iron deficiency: A cross-sectional study Open
Background Caregivers of young children may have been particularly vulnerable to mental health challenges during the COVID-19 pandemic due to its negative impacts on their housing, finances, and childcare demands. This study explored the a…
View article: Severe falciparum malaria in young children is associated with an increased risk of post-discharge hospitalization: a prospective cohort study
Severe falciparum malaria in young children is associated with an increased risk of post-discharge hospitalization: a prospective cohort study Open
In this malaria endemic region, children with the five most common forms of SM had higher rates of post-discharge hospitalization than asymptomatic community children, and > 80% of hospitalizations were due to severe malaria. Studies of po…
View article: Physical, sexual and overall reported interpersonal violence against adult out-patients with severe mental illness under remission, receiving healthcare at Butabika hospital: A cross-sectional study
Physical, sexual and overall reported interpersonal violence against adult out-patients with severe mental illness under remission, receiving healthcare at Butabika hospital: A cross-sectional study Open
Interpersonal violence is a significant public health and human rights concern. People living with severe mental illness are especially vulnerable. The Sustainable Development Goals 2030 Agenda aims to end violence. To this end, we gathere…
View article: Severe falciparum malaria in young children is associated with an increased risk of post-discharge readmission or death: A prospective cohort study
Severe falciparum malaria in young children is associated with an increased risk of post-discharge readmission or death: A prospective cohort study Open
View article: Academic achievement in Ugandan children with sickle cell anaemia: A cross-sectional study
Academic achievement in Ugandan children with sickle cell anaemia: A cross-sectional study Open
Introduction: Academic achievement is crucial for advancing learning goals. For disease-related and possibly additional reasons, children with sickle cell anaemia (SCA) in Sub-Saharan Africa (SSA) may be at risk of disease-associated schoo…
View article: Academic achievement in Ugandan children with sickle cell anaemia: A cross-sectional study
Academic achievement in Ugandan children with sickle cell anaemia: A cross-sectional study Open
Objective Academic achievement in school-age children is crucial for advancing learning goals. Children with sickle cell anaemia (SCA) in Sub-Saharan Africa may be at risk of disease-associated school difficulties. Limited data exist on th…
View article: Neurocognitive impairment in Ugandan children with sickle cell anemia compared to sibling controls: a cross-sectional study
Neurocognitive impairment in Ugandan children with sickle cell anemia compared to sibling controls: a cross-sectional study Open
Introduction The neurocognitive functions in Ugandan children aged 1–12 years with sickle cell anemia (SCA) were compared to their non-SCA siblings to identify risk factors for disease-associated impairment. Methods This cross-sectional st…
View article: Apolipoprotein-E4: risk of severe malaria and mortality and cognitive impairment in pediatric cerebral malaria
Apolipoprotein-E4: risk of severe malaria and mortality and cognitive impairment in pediatric cerebral malaria Open
View article: Neurocognitive Impairment in Ugandan Children with Sickle Cell Anemia Compared to Sibling Controls: A cross-sectional study
Neurocognitive Impairment in Ugandan Children with Sickle Cell Anemia Compared to Sibling Controls: A cross-sectional study Open
Introduction Neurocognitive function in Ugandan children aged 1-12 years with sickle cell anemia (SCA) were compared to their non-SCA siblings to identify risk factors for disease-associated impairment. Methods This cross-sectional neuroco…
View article: Effect of Hydroxyurea Treatment on Body Composition in Children with Sickle Cell Anemia in Uganda Using Bioelectrical Impedance Analysis (BIA)
Effect of Hydroxyurea Treatment on Body Composition in Children with Sickle Cell Anemia in Uganda Using Bioelectrical Impedance Analysis (BIA) Open
Introduction Children with sickle cell anemia (SCA) experience severe illness and risk of malnutrition in sub-Saharan Africa. Treatment with hydroxyurea (HU) decreases SCA complications. In high-income regions, hydroxyurea also improves pe…
View article: Neurocognitive Improvement with Hydroxyurea Therapy in Children with Sickle Cell Anemia in Uganda: Interim Analysis at Month 18
Neurocognitive Improvement with Hydroxyurea Therapy in Children with Sickle Cell Anemia in Uganda: Interim Analysis at Month 18 Open
Introduction: Cerebrovascular injury can lead to neurocognitive impairment in children with sickle cell anemia (SCA). The prospective impact of hydroxyurea therapy on neurocognitive function has not been previously reported in a large samp…
View article: “She gives it to her child who doesn’t even talk”: a qualitative exploration of alcohol and drug use among primary school-age children in Uganda
“She gives it to her child who doesn’t even talk”: a qualitative exploration of alcohol and drug use among primary school-age children in Uganda Open
View article: Child-focused evaluation: Involving children as their own respondents
Child-focused evaluation: Involving children as their own respondents Open
Background: Undertaking child-focused evaluations using a participatory approach has received recognition in recent years. Such an approach is critical not only to build capacity amongst children and youth but also to increase the rigour, …
View article: Neurofilament light chain: A potential biomarker for cerebrovascular disease in children with sickle cell anaemia
Neurofilament light chain: A potential biomarker for cerebrovascular disease in children with sickle cell anaemia Open
Summary Cerebrovascular injury frequently occurs in children with sickle cell anaemia (SCA). Limited access to magnetic resonance imaging and angiography (MRI‐MRA) in sub‐Saharan Africa impedes detection of clinically unapparent cerebrovas…
View article: Admission Clinical and EEG Features Associated With Mortality and Long-term Neurologic and Cognitive Outcomes in Pediatric Cerebral Malaria
Admission Clinical and EEG Features Associated With Mortality and Long-term Neurologic and Cognitive Outcomes in Pediatric Cerebral Malaria Open
In children with cerebral malaria, seizure number is strongly associated with the risk of long-term neurologic deficits, while seizure number and specific EEG features (average background voltage, dominant rhythm frequency, presence of ver…
View article: Association of severe malaria with cognitive and behavioural outcomes in low- and middle-income countries: a meta-analysis and systematic review
Association of severe malaria with cognitive and behavioural outcomes in low- and middle-income countries: a meta-analysis and systematic review Open
View article: Cerebrospinal fluid biomarkers provide evidence for kidney-brain axis involvement in cerebral malaria pathogenesis
Cerebrospinal fluid biomarkers provide evidence for kidney-brain axis involvement in cerebral malaria pathogenesis Open
Introduction Cerebral malaria is one of the most severe manifestations of malaria and is a leading cause of acquired neurodisability in African children. Recent studies suggest acute kidney injury (AKI) is a risk factor for brain injury in…
View article: Severe Malaria and Academic Achievement
Severe Malaria and Academic Achievement Open
BACKGROUND Cerebral malaria (CM) and severe malarial anemia (SMA) are associated with neurocognitive impairment in childhood but their effects on long-term academic achievement are not known. METHODS Ugandan children 5 to 12 years old who …
View article: Early Antiretroviral Therapy Reduces Severity but Does Not Eliminate Neurodevelopmental Compromise in Children With HIV
Early Antiretroviral Therapy Reduces Severity but Does Not Eliminate Neurodevelopmental Compromise in Children With HIV Open
Background: Early antiretroviral therapy (ART) during infancy reduces cognitive impairment due to HIV, but the extent of benefit is unclear. Setting: Children were recruited from hospital and health centers providing HIV care and treatment…
View article: Community based sociotherapy for depressive symptomatology of Congolese refugees in Rwanda and Uganda (CoSTAR): a protocol for a cluster randomised controlled trial
Community based sociotherapy for depressive symptomatology of Congolese refugees in Rwanda and Uganda (CoSTAR): a protocol for a cluster randomised controlled trial Open
Background: Conflict in the Democratic Republic of Congo has led to large numbers of refugees fleeing to Uganda and Rwanda. Refugees experience elevated levels of adverse events and daily stressors, which are associated with common …
View article: Blood biomarkers of neuronal injury in paediatric cerebral malaria and severe malarial anaemia
Blood biomarkers of neuronal injury in paediatric cerebral malaria and severe malarial anaemia Open
Persistent neurodisability is a known complication in paediatric survivors of cerebral malaria and severe malarial anaemia. Tau, ubiquitin C-terminal hydrolase-L1, neurofilament-light chain, and glial fibrillary acidic protein have proven …
View article: Effect of Malaria and Malaria Chemoprevention Regimens in Pregnancy and Childhood on Neurodevelopmental and Behavioral Outcomes in Children at 12, 24, and 36 Months: A Randomized Clinical Trial
Effect of Malaria and Malaria Chemoprevention Regimens in Pregnancy and Childhood on Neurodevelopmental and Behavioral Outcomes in Children at 12, 24, and 36 Months: A Randomized Clinical Trial Open
Background Malaria in pregnancy has been associated with worse cognitive outcomes in children, but its association with behavioral outcomes and the effectiveness of malaria chemoprevention on child neurodevelopment are not well characteriz…