Paul Bensadoun
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View article: Associations of Skin Biomechanical Properties With Biological Aging Clocks and Longitudinal Changes in Intrinsic Capacity in Adults Aged 20–93: The <scp>INSPIRE</scp>‐T Project
Associations of Skin Biomechanical Properties With Biological Aging Clocks and Longitudinal Changes in Intrinsic Capacity in Adults Aged 20–93: The <span>INSPIRE</span>‐T Project Open
Evidence connecting skin aging to functional decline and systemic aging biomarkers is lacking. This study investigated how skin‐aging biomechanics were associated with changes in intrinsic capacity (IC), a marker of healthy aging. We also …
View article: Biological Ageing Acceleration and Functional Capacities Across the Lifespan in the INSPIRE‐T Cohort
Biological Ageing Acceleration and Functional Capacities Across the Lifespan in the INSPIRE‐T Cohort Open
Background Biological clocks are promising tools for the evaluation of biological age deviations (i.e., positive/negative acceleration). Here, we explored the associations of biological age acceleration (BAA) assessed by Horvath's, Hannum'…
View article: Somatic cell reprogramming from different origins and donors into iPSC, with four factors OSKM using viral Sendai vectors
Somatic cell reprogramming from different origins and donors into iPSC, with four factors OSKM using viral Sendai vectors Open
View article: The associations between biological markers of aging and appetite loss across adulthood: retrospective case–control data from the INSPIRE-T study
The associations between biological markers of aging and appetite loss across adulthood: retrospective case–control data from the INSPIRE-T study Open
View article: Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging
Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging Open
View article: A single short reprogramming early in life initiates and propagates an epigenetically related mechanism improving fitness and promoting an increased healthy lifespan
A single short reprogramming early in life initiates and propagates an epigenetically related mechanism improving fitness and promoting an increased healthy lifespan Open
Recent advances in cell reprogramming showed that OSKM induction is able to improve cell physiology in vitro and in vivo. Here, we show that a single short reprogramming induction is sufficient to prevent musculoskeletal functions deterior…
View article: 2nd EURO GEROSCIENCE Conference Oral Communications
2nd EURO GEROSCIENCE Conference Oral Communications Open
View article: Cellular senescence induces replication stress with almost no affect on DNA replication timing
Cellular senescence induces replication stress with almost no affect on DNA replication timing Open
Organismal aging entails a gradual decline of normal physiological functions and a major contributor to this decline is withdrawal of the cell cycle, known as senescence. Senescence can result from telomere diminution leading to a finite n…
View article: 356 Investigating for Extracellular Vesicles miRNA involved in the dialog between dermis and epidermis, as potential targets for antiaging interventions in skin
356 Investigating for Extracellular Vesicles miRNA involved in the dialog between dermis and epidermis, as potential targets for antiaging interventions in skin Open
View article: 373 Effect of Haritaki fruit extract on Senescence Associated Secretory Phenotype and miR 30a-3p over-expression in senescent dermal fibroblasts’ extracellular vesicles
373 Effect of Haritaki fruit extract on Senescence Associated Secretory Phenotype and miR 30a-3p over-expression in senescent dermal fibroblasts’ extracellular vesicles Open
View article: A single short reprogramming early in life improves fitness and increases lifespan in old age
A single short reprogramming early in life improves fitness and increases lifespan in old age Open
Forced and maintained expression of four transcription factors OCT4, SOX2, KLF4 and c-MYC (OSKM), can reprogram somatic cells into induced Pluripotent Stem Cells (iPSCs) and a limited OSKM induction is able to rejuvenate the cell physiolog…
View article: Maternal vitamin D deficiency impairs heart formation in mouse offspring through a change in 3D-chromatin structure
Maternal vitamin D deficiency impairs heart formation in mouse offspring through a change in 3D-chromatin structure Open
The origins of congenital heart diseases, the most common congenital diseases are still largely unknown. Environmental factors are now emerging as major causes of these diseases. Vitamin D deficiency has become a public health burden, nota…
View article: 4D Genome Rewiring during Oncogene-Induced and Replicative Senescence
4D Genome Rewiring during Oncogene-Induced and Replicative Senescence Open
View article: Modulation of the ATM/autophagy pathway by a G-quadruplex ligand tips the balance between senescence and apoptosis in cancer cells
Modulation of the ATM/autophagy pathway by a G-quadruplex ligand tips the balance between senescence and apoptosis in cancer cells Open
G-quadruplex ligands exert their antiproliferative effects through telomere-dependent and telomere-independent mechanisms, but the inter-relationships among autophagy, cell growth arrest and cell death induced by these ligands remain large…
View article: Cellular senescence induces replication stress with almost no affect on DNA replication timing
Cellular senescence induces replication stress with almost no affect on DNA replication timing Open
Organismal aging entails a gradual decline of normal physiological functions and a major contributor to this decline is withdrawal of the cell cycle, known as senescence. Senescence can result from telomere diminution leading to a finite n…
View article: Cellular senescence induces replication stress with almost no affect on DNA replication timing
Cellular senescence induces replication stress with almost no affect on DNA replication timing Open
Organismal aging entails a gradual decline of normal physiological functions and a major contributor to this decline is withdrawal of the cell cycle, known as senescence. Senescence can result from telomere diminution leading to a finite n…
View article: Cellular senescence induces replication stress without affecting DNA replication timing
Cellular senescence induces replication stress without affecting DNA replication timing Open
Organismal aging entails a gradual decline of normal physiological functions and a major contributor to this decline is withdrawal of the cell cycle, known as senescence. Senescence can result from telomere diminution leading to a finite n…