Paul Blanche
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View article: Surgeon Training and Revision Rates After Patellofemoral Arthroplasty
Surgeon Training and Revision Rates After Patellofemoral Arthroplasty Open
Importance Surgeon training with a specific implant is often not considered in implant registry–based studies, which may lead to unobserved confounding bias. Discrepancies between registry and clinical trial outcomes for patellofemoral art…
View article: Design and Analysis of Group Sequential Trials for Repeated Measurements When Pipeline Data Occurs: A Tutorial
Design and Analysis of Group Sequential Trials for Repeated Measurements When Pipeline Data Occurs: A Tutorial Open
Group sequential trials (GST) allow for early stopping of a clinical trial for efficacy or futility, without compromising its validity. Statistical methodology for GST is well established when the endpoint is observed immediately, but less…
View article: Normal and melanoma skin visualized, quantified and compared by in vivo photoacoustic imaging
Normal and melanoma skin visualized, quantified and compared by in vivo photoacoustic imaging Open
View article: timeEL: Time to Event Analysis via Empirical Likelihood Inference
timeEL: Time to Event Analysis via Empirical Likelihood Inference Open
View article: Propensity weighting plus adjustment in proportional hazards model is not doubly robust
Propensity weighting plus adjustment in proportional hazards model is not doubly robust Open
Recently, it has become common for applied works to combine commonly used survival analysis modeling methods, such as the multivariable Cox model and propensity score weighting, with the intention of forming a doubly robust estimator of an…
View article: The importance of considering competing risks in recurrence analysis of intracranial meningioma
The importance of considering competing risks in recurrence analysis of intracranial meningioma Open
Background The risk of recurrence is overestimated by the Kaplan–Meier method when competing events, such as death without recurrence, are present. Such overestimation can be avoided by using the Aalen-Johansen method, which is a direct ex…
View article: Exploring the potential use of platelet rich plasma (PRP) from adult and umbilical cord blood in murine follicle culture
Exploring the potential use of platelet rich plasma (PRP) from adult and umbilical cord blood in murine follicle culture Open
Ovarian follicle culture is a powerful tool to study follicular physiology and has potential applications in clinical and commercial settings. Despite remarkable progress, recreating folliculogenesis in vitro remains challenging for many m…
View article: Propensity weighting plus adjustment in proportional hazards model is not doubly robust
Propensity weighting plus adjustment in proportional hazards model is not doubly robust Open
Recently, it has become common for applied works to combine commonly used survival analysis modeling methods, such as the multivariable Cox model and propensity score weighting, with the intention of forming a doubly robust estimator of an…
View article: Incidence of depression in patients with cardiovascular disease and type 2 diabetes: a nationwide cohort study
Incidence of depression in patients with cardiovascular disease and type 2 diabetes: a nationwide cohort study Open
Background Estimating how type 2 diabetes (T2D) affects the rate of depression in cardiovascular disease (CVD) can help identify high-risk patients. The aim is to investigate how T2D affects the rate of depression according to specific sub…
View article: Post-prandial secretion of glucagon-like peptide-2 (GLP-2) after carbohydrate-, fat- or protein enriched meals in healthy subjects
Post-prandial secretion of glucagon-like peptide-2 (GLP-2) after carbohydrate-, fat- or protein enriched meals in healthy subjects Open
Glucagon-like peptide 2 (GLP-2) is an important regulator of intestinal growth and function. In adherable mixed meals the macronutrient composition with the best potential for stimulating GLP-2 secretion is not known. We compared the effec…
View article: Treated periodontitis and recurrent events after first‐time myocardial infarction: A Danish nationwide cohort study
Treated periodontitis and recurrent events after first‐time myocardial infarction: A Danish nationwide cohort study Open
Aim To investigate the association between previous periodontal treatment and recurrent events after first‐time myocardial infarction (MI). Materials and Methods From the Danish nationwide registries, patients with first‐time MI between 20…
View article: Human platelet lysate improves the growth and survival of cultured human pre-antral follicles
Human platelet lysate improves the growth and survival of cultured human pre-antral follicles Open
View article: Transplantation of initially rejected donor lungs using ex vivo lung perfusion: A 5‐year experience
Transplantation of initially rejected donor lungs using ex vivo lung perfusion: A 5‐year experience Open
Background Ex vivo lung perfusion (EVLP) is a method for the evaluation and reconditioning of high‐risk donor lungs to increase the pool of potential donor lungs. Methods We reviewed all consecutive patients who received lung transplants f…
View article: Post-Prandial Secretion of Glucagon-Like Peptide-2 (Glp-2) after Carbohydrate-, Fat- or Protein Enriched Meals in Healthy Subjects
Post-Prandial Secretion of Glucagon-Like Peptide-2 (Glp-2) after Carbohydrate-, Fat- or Protein Enriched Meals in Healthy Subjects Open
View article: Antiplatelet therapy and risk of adverse cardiovascular events in peripheral artery disease
Antiplatelet therapy and risk of adverse cardiovascular events in peripheral artery disease Open
Background Antiplatelet therapy has been shown to reduce adverse cardiovascular (CV) events in patients with PAD, but despite the well-established medication benefit, large-scale epidemiological data evaluating antiplatelet agent of choice…
View article: Cardiovascular risk following cannabinoid treatment for patients with chronic pain
Cardiovascular risk following cannabinoid treatment for patients with chronic pain Open
Background Treatment with medical cannabis for chronic pain is in popular demand, and a rising number of countries allow physicians to prescribe medical cannabis for pain management. However, data on drug-safety is scarce. Studies have sho…
View article: Risk of heart failure following short-term non-steroidal anti-inflammatory drug use in patients with type 2 diabetes mellitus
Risk of heart failure following short-term non-steroidal anti-inflammatory drug use in patients with type 2 diabetes mellitus Open
Background Fluid retention is a known but underappreciated side-effect of non-steroidal anti-inflammatory drug (NSAID) use. As type 2 diabetes mellitus (T2DM) has been linked to both subclinical cardiomyopathy and a decline in kidney funct…
View article: Acute kidney injury and risk of cardiovascular outcomes: A nationwide cohort study
Acute kidney injury and risk of cardiovascular outcomes: A nationwide cohort study Open
Non-selected patients aged 50 years or above with AKI during admission had significantly higher one-year risk of cardiovascular event or death, especially, but not only due to heart failure, independent of age and eGFR.
View article: Derivation and validation of the Rapid Assessment of Dementia Risk (RADaR) for older adults
Derivation and validation of the Rapid Assessment of Dementia Risk (RADaR) for older adults Open
Background There is no practical dementia risk score in the clinical setting. Objective To derive and validate a score obtained by a rapid and simple assessment, which guides primary care providers in predicting the risk of dementia among …
View article: Bleeding Risk Following Systemic Fluconazole or Topical Azoles in Patients with Atrial Fibrillation on Apixaban, Rivaroxaban, or Dabigatran
Bleeding Risk Following Systemic Fluconazole or Topical Azoles in Patients with Atrial Fibrillation on Apixaban, Rivaroxaban, or Dabigatran Open
View article: Electrical cardioversion of atrial fibrillation and the risk of brady-arrhythmic events
Electrical cardioversion of atrial fibrillation and the risk of brady-arrhythmic events Open
View article: Usage and risk with phosphodiesterase type 5 inhibitors in male patients with chronic ischemic heart disease on oral organic nitrates
Usage and risk with phosphodiesterase type 5 inhibitors in male patients with chronic ischemic heart disease on oral organic nitrates Open
Background Combining oral organic nitrates (OON) with phosphodiesterase type 5 (PDE5) inhibitors is contraindicated. Growing and liberal use of PDE5 inhibitors for erectile dysfunction among patients with ischemic heart disease (IHD) could…
View article: Acute kidney injury and risk of cardiovascular outcomes: A nationwide cohort study
Acute kidney injury and risk of cardiovascular outcomes: A nationwide cohort study Open
Non-selected patients aged 50 years or above with AKI during admission had significantly higher one-year risk of cardiovascular event or death, especially, but not only due to heart failure, independent of age and eGFR.
View article: Temporal trends and sex differences in sudden cardiac death in the Copenhagen City Heart Study
Temporal trends and sex differences in sudden cardiac death in the Copenhagen City Heart Study Open
Objective More knowledge about the development of sudden cardiac death (SCD) in the general population is needed to develop meaningful predictors of SCD. Our aim with this study was to estimate the incidence of SCD in the …
View article: Temporal changes in myocardial infarction diagnostic criteria do not account for the lack of long-term beta-blocker effect on cardiovascular prognosis
Temporal changes in myocardial infarction diagnostic criteria do not account for the lack of long-term beta-blocker effect on cardiovascular prognosis Open
View article: Effect of government interventions to contain the COVID-19 pandemic on incidence of pulmonary embolism - A Danish nationwide register-based cohort study
Effect of government interventions to contain the COVID-19 pandemic on incidence of pulmonary embolism - A Danish nationwide register-based cohort study Open
View article: Effect of long-term beta-blocker treatment following myocardial infarction among stable, optimally treated patients without heart failure in the reperfusion era: a Danish, nationwide cohort study
Effect of long-term beta-blocker treatment following myocardial infarction among stable, optimally treated patients without heart failure in the reperfusion era: a Danish, nationwide cohort study Open
Aims We aimed to investigate the long-term cardio-protective effect associated with beta-blocker (BB) treatment in stable, optimally treated myocardial infarction (MI) patients without heart failure (HF). Methods and results Using nationwi…
View article: Effect of beta blocker therapy following myocardial infarction in optimally treated patients in the reperfusion era – a Danish, nationwide, and registry-based cohort study
Effect of beta blocker therapy following myocardial infarction in optimally treated patients in the reperfusion era – a Danish, nationwide, and registry-based cohort study Open
Background and purpose European and American cardiovascular treatment guidelines advocate for two and three years of beta-blocker (BB) treatment, respectively, following myocardial infarction (MI). Contemporary continued efficacy of longer…
View article: Increased risk of neonatal complications and infections in children of kidney-transplanted women: A nationwide controlled cohort study
Increased risk of neonatal complications and infections in children of kidney-transplanted women: A nationwide controlled cohort study Open
Information related to short- and long-term risks of children born to kidney-transplanted women remains limited. With the aim of investigating the risk of neonatal complications, and the short- and long-term risk of infections in offspring…
View article: Thromboembolic events related to atrial fibrillation during the COVID-19 epidemic in Denmark
Thromboembolic events related to atrial fibrillation during the COVID-19 epidemic in Denmark Open