Paul Briaud
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View article: Analysis of Teg41 and PSMα promoter activity using a divergent fluorescent reporter plasmid
Analysis of Teg41 and PSMα promoter activity using a divergent fluorescent reporter plasmid Open
Staphylococcus aureus is a common commensal of human skin and anterior nares but also a notable pathogen, causing a range of diseases from minor skin infections to serious, often fatal conditions. The global health community considers S. a…
View article: The role of colony morphotype in shaping gene essentiality in <i>Mycobacteroides abscessus</i>
The role of colony morphotype in shaping gene essentiality in <i>Mycobacteroides abscessus</i> Open
Changes in bacterial colony morphology are common during chronic human infections and are thought to provide a survival advantage. In the human pathogen Mycobacteroides abscessus (MAB), a unidirectional transition from a smooth (MAB S ) to…
View article: The <i>Staphylococcus aureus</i> non-coding RNA IsrR regulates TCA cycle activity and virulence
The <i>Staphylococcus aureus</i> non-coding RNA IsrR regulates TCA cycle activity and virulence Open
Staphylococcus aureus has evolved mechanisms to cope with low iron (Fe) availability in host tissues. Staphylococcus aureus uses the ferric uptake transcriptional regulator (Fur) to sense titers of cytosolic Fe. Upon Fe depletion, apo-Fur …
View article: The<i>Staphylococcus aureus</i>small non-coding RNA IsrR regulates TCA cycle activity and virulence
The<i>Staphylococcus aureus</i>small non-coding RNA IsrR regulates TCA cycle activity and virulence Open
Staphylococcus aureus has evolved mechanisms to cope with low iron (Fe) availability in host tissues. S. aureus uses the ferric uptake transcriptional regulator (Fur) to sense titers of cytosolic Fe. Upon Fe depletion, apo-Fur relieves tra…
View article: The Streptococcus agalactiae Exonuclease ExoVII Is Required for Resistance to Exogenous DNA-Damaging Agents
The Streptococcus agalactiae Exonuclease ExoVII Is Required for Resistance to Exogenous DNA-Damaging Agents Open
This study examined the role of the ExoVII exonuclease of Streptococcus agalactiae within the different DNA repair processes. Our results concluded that ExoVII is involved in bacterial recovery after exposure to different exogenous DNA-dam…
View article: The Small Protein ScrA Influences Staphylococcus aureus Virulence-Related Processes via the SaeRS System
The Small Protein ScrA Influences Staphylococcus aureus Virulence-Related Processes via the SaeRS System Open
Staphylococcus aureus is the cause of several potentially life-threatening infections. An assortment of toxins and virulence factors allows such a wide range of infections.
View article: The Small RNA Teg41 Is a Pleiotropic Regulator of Virulence in Staphylococcus aureus
The Small RNA Teg41 Is a Pleiotropic Regulator of Virulence in Staphylococcus aureus Open
Previously, our group demonstrated a role for the small RNA (sRNA) Teg41 in regulating production of the alpha phenol-soluble modulin toxins (αPSMs) in Staphylococcus aureus . Overexpressing Teg41 increased αPSM production while deleting t…
View article: RNase III CLASH in MRSA uncovers sRNA regulatory networks coupling metabolism to toxin expression
RNase III CLASH in MRSA uncovers sRNA regulatory networks coupling metabolism to toxin expression Open
Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterial pathogen responsible for significant human morbidity and mortality. Post-transcriptional regulation by small RNAs (sRNAs) has emerged as an important mechanism for controlli…
View article: RNase III CLASH in MRSA uncovers sRNA regulatory networks coupling metabolism to toxin expression
RNase III CLASH in MRSA uncovers sRNA regulatory networks coupling metabolism to toxin expression Open
Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterial pathogen responsible for significant human morbidity and mortality. Post-transcriptional regulation by small RNAs (sRNAs) has emerged as an important mechanism for …
View article: The novel protein <scp>ScrA</scp> acts through the <scp>SaeRS</scp> two‐component system to regulate virulence gene expression in <i>Staphylococcus aureus</i>
The novel protein <span>ScrA</span> acts through the <span>SaeRS</span> two‐component system to regulate virulence gene expression in <i>Staphylococcus aureus</i> Open
Staphylococcus aureus is a Gram‐positive commensal that can also cause a variety of infections in humans. S. aureus virulence factor gene expression is under tight control by a complex regulatory network, which includes, sigma factors, sRN…
View article: Temperature Influences the Composition and Cytotoxicity of Extracellular Vesicles in Staphylococcus aureus
Temperature Influences the Composition and Cytotoxicity of Extracellular Vesicles in Staphylococcus aureus Open
Extracellular vesicles (EVs) are lipid bilayer spheres that contain proteins, nucleic acids, and lipids secreted by bacteria. They are involved in Staphylococcus aureus infections, as they package virulence factors and deliver their conten…
View article: How Bacterial Adaptation to Cystic Fibrosis Environment Shapes Interactions Between Pseudomonas aeruginosa and Staphylococcus aureus
How Bacterial Adaptation to Cystic Fibrosis Environment Shapes Interactions Between Pseudomonas aeruginosa and Staphylococcus aureus Open
Pseudomonas aeruginosa and Staphylococcus aureus are the two most prevalent bacteria species in the lungs of cystic fibrosis (CF) patients and are associated with poor clinical outcomes. Co-infection by the two species is a frequent situat…
View article: Extracellular Vesicle Biogenesis and Functions in Gram-Positive Bacteria
Extracellular Vesicle Biogenesis and Functions in Gram-Positive Bacteria Open
Extracellular vesicles (EVs) are membrane-derived lipid bilayers secreted by bacteria and eukaryotic cells. Bacterial membrane vesicles were discovered over 60 years ago and have been extensively studied in Gram-negative bacteria. During t…
View article: Trophic cooperation promotes bacterial survival of <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i>
Trophic cooperation promotes bacterial survival of <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i> Open
In the context of infection, Pseudomonas aeruginosa and Staphylococcus aureus are frequently co-isolated, particularly in cystic fibrosis (CF) patients. Within lungs, the two pathogens exhibit a range of competitive and coexisting interact…
View article: Trophic cooperation promotes bacterial survival of<i>Staphylococcus aureus</i>and<i>Pseudomonas aeruginosa</i>
Trophic cooperation promotes bacterial survival of<i>Staphylococcus aureus</i>and<i>Pseudomonas aeruginosa</i> Open
In the context of infection, Pseudomonas aeruginosa and Staphylococcus aureus are frequently co-isolated, particularly in cystic fibrosis (CF) patients. Within lungs, the two pathogens exhibit a range of competitive and coexisting interact…
View article: Impact of Coexistence Phenotype Between Staphylococcus aureus and Pseudomonas aeruginosa Isolates on Clinical Outcomes Among Cystic Fibrosis Patients
Impact of Coexistence Phenotype Between Staphylococcus aureus and Pseudomonas aeruginosa Isolates on Clinical Outcomes Among Cystic Fibrosis Patients Open
Staphylococcus aureus (SA) is the major colonizer of the lungs of cystic fibrosis (CF) patients during childhood and adolescence. As patients age, the prevalence of SA decreases and Pseudomonas aeruginosa (PA) becomes the maj…
View article: P128 Trophic cooperation promotes Pseudomonas aeruginosa and Staphylococcus aureus survival in cystic fibrosis patients
P128 Trophic cooperation promotes Pseudomonas aeruginosa and Staphylococcus aureus survival in cystic fibrosis patients Open
View article: P131 Most of Staphylococcus aureus and Pseudomonas aeruginosa coinfecting isolates coexist, a condition that may impact clinical outcomes in cystic fibrosis patients
P131 Most of Staphylococcus aureus and Pseudomonas aeruginosa coinfecting isolates coexist, a condition that may impact clinical outcomes in cystic fibrosis patients Open
View article: Most of <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i> co-infecting isolates coexist, a condition that may impact clinical outcomes in Cystic Fibrosis patients
Most of <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i> co-infecting isolates coexist, a condition that may impact clinical outcomes in Cystic Fibrosis patients Open
Staphylococcus aureus (SA) is the major colonizer of the lung of cystic fibrosis (CF) patient during childhood and adolescence. As patient aged, the prevalence of SA decreases and Pseudomonas aeruginosa (PA) becomes the major pathogen infe…
View article: Impact of Pseudomonas aeruginosa on Staphylococcus aureus in a context of coexistence in cystic fibrosis patient lung
Impact of Pseudomonas aeruginosa on Staphylococcus aureus in a context of coexistence in cystic fibrosis patient lung Open
Les poumons des patients atteints de mucoviscidose (CF) sont séquentiellement colonisés par Staphylococcus aureus puis par Pseudomonas aeruginosa (PA). Lors de cette colonisation, ces deux bactéries interagissent l’une avec l’autre selon d…
View article: Impact de Pseudomonas aeruginosa sur Staphylococcus aureus dans un contexte de coexistence bactérienne chez les patients atteints de mucoviscidose
Impact de Pseudomonas aeruginosa sur Staphylococcus aureus dans un contexte de coexistence bactérienne chez les patients atteints de mucoviscidose Open
Cystic fibrosis (CF) patient lung are colonized by Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA) in this subsequent order. These bacteria interact each other during this colonization and two different interaction states are of…
View article: NorK, a novel norfloxacin efflux pump in <i>Staphylococcus aureus</i>
NorK, a novel norfloxacin efflux pump in <i>Staphylococcus aureus</i> Open
A novel efflux pump similar to Nor efflux pumps and designated as NorK was identified in Staphylococcus aureus . It contributes to norfloxacin resistance and presents a high level of expression in different strains. Its expression is not r…
View article: Coexistence with Pseudomonas aeruginosa alters Staphylococcus aureus transcriptome, antibiotic resistance and internalization into epithelial cells
Coexistence with Pseudomonas aeruginosa alters Staphylococcus aureus transcriptome, antibiotic resistance and internalization into epithelial cells Open
View article: Coexistence with<i>Pseudomonas aeruginosa</i>alters<i>Staphylococcus aureus</i>transcriptome, antibiotic resistance and internalization into epithelial cells
Coexistence with<i>Pseudomonas aeruginosa</i>alters<i>Staphylococcus aureus</i>transcriptome, antibiotic resistance and internalization into epithelial cells Open
Cystic fibrosis (CF) is the most common life-threatening genetic disease among Caucasians. CF patients suffer from chronic lung infections due to the presence of thick mucus, caused by cftr gene dysfunction. The two most commonly found bac…