Paul C. Evans
YOU?
Author Swipe
View article: GLM7 – A Novel Composite Glycolipid Index Derived from Routine Health Indicators for Enhanced Diagnosis and Prediction of Multimorbidity
GLM7 – A Novel Composite Glycolipid Index Derived from Routine Health Indicators for Enhanced Diagnosis and Prediction of Multimorbidity Open
Routine health examinations for healthy adults typically involve measurements such as height, weight, blood biochemistry, complete blood count, and urinalysis. However, the current scope of physical examinations has expanded to include num…
View article: HIV infection, antiretroviral therapy and vascular dysfunction: Effects, mechanisms and treatments
HIV infection, antiretroviral therapy and vascular dysfunction: Effects, mechanisms and treatments Open
With the extensive implementation of antiretroviral therapy (ART), the life expectancy of people living with HIV (PLWH) has markedly extended. However, this clinical success has been followed with a rising incidence of cardiovascular disea…
View article: TWIST1 drives endothelial-to-mesenchymal-transition to stabilize atherosclerotic plaques
TWIST1 drives endothelial-to-mesenchymal-transition to stabilize atherosclerotic plaques Open
Atherosclerosis progresses from fatty streaks to complex plaques, with rupture leading to life-threatening complications. Endothelial-to-mesenchymal transition (EndMT) is associated with advanced atherosclerotic plaques, but its role in pl…
View article: Mitochondrial targets in ischaemic heart disease and heart failure, and their potential for a more efficient clinical translation. A scientific statement of the <scp>ESC</scp> Working Group on Cellular Biology of the Heart and the <scp>ESC</scp> Working Group on Myocardial Function
Mitochondrial targets in ischaemic heart disease and heart failure, and their potential for a more efficient clinical translation. A scientific statement of the <span>ESC</span> Working Group on Cellular Biology of the Heart and the <span>ESC</span> Working Group on Myocardial Function Open
Acute myocardial infarction (MI) remains a major cause of death and disability worldwide. No adjuvant treatment has yet been fully validated in patients to limit the progression from the initial tissue damage due to acute MI, to the develo…
View article: Nitrate-reducing microorganisms prevent souring of an oil field produced water storage pond
Nitrate-reducing microorganisms prevent souring of an oil field produced water storage pond Open
Nitrate addition for mitigating sulfide production in oil field systems has been studied in laboratory settings and in some subsurface oil reservoirs. To promote water recycling and reuse associated with oil reservoirs produced by hydrauli…
View article: Polymer biodegradation by <i>Halanaerobium</i> promotes reservoir souring during hydraulic fracturing
Polymer biodegradation by <i>Halanaerobium</i> promotes reservoir souring during hydraulic fracturing Open
Hydraulically fractured shale reservoirs have facilitated studies of unexplored niches in the continental deep biosphere. In high-salinity North American shale systems, members of the genus Halanaerobium seem to be ubiquitous. Polymers lik…
View article: Endothelial MICU1 protects against vascular inflammation and atherosclerosis by inhibiting mitochondrial calcium uptake
Endothelial MICU1 protects against vascular inflammation and atherosclerosis by inhibiting mitochondrial calcium uptake Open
Mitochondrial dysfunction fuels vascular inflammation and atherosclerosis. Mitochondrial calcium uptake 1 (MICU1) maintains mitochondrial Ca2+ homeostasis. However, the role of MICU1 in vascular inflammation and atherosclerosis remains unk…
View article: A natural small molecule isoginkgetin alleviates hypercholesterolemia and atherosclerosis by targeting ACLY
A natural small molecule isoginkgetin alleviates hypercholesterolemia and atherosclerosis by targeting ACLY Open
Rationale: Atherosclerotic cardiovascular disease (ASCVD) represents the predominant cause of mortality and morbidity globally. Given the established role of hypercholesterolemia as a significant risk factor for ASCVD, the discovery…
View article: Endothelial c-REL orchestrates atherosclerosis at regions of disturbed flow through crosstalk with TXNIP-p38 and non-canonical NF-κB pathways
Endothelial c-REL orchestrates atherosclerosis at regions of disturbed flow through crosstalk with TXNIP-p38 and non-canonical NF-κB pathways Open
Aims Atherosclerosis initiation at sites of disturbed blood flow involves heightened inflammation coupled to excessive endothelial cell (EC) proliferation. Here, we unveil the pivotal role of c-REL, a member of the NF-κB transcription fact…
View article: Roadmap for alleviating the manifestations of ageing in the cardiovascular system
Roadmap for alleviating the manifestations of ageing in the cardiovascular system Open
View article: Opportunities and challenges for the use of human samples in translational cardiovascular research: a scientific statement of the ESC Working Group on Cellular Biology of the Heart, the ESC Working Group on Cardiovascular Surgery, the ESC Council on Basic Cardiovascular Science, the ESC Scientists of Tomorrow, the European Association of Percutaneous Cardiovascular Interventions of the ESC, and the Heart Failure Association of the ESC
Opportunities and challenges for the use of human samples in translational cardiovascular research: a scientific statement of the ESC Working Group on Cellular Biology of the Heart, the ESC Working Group on Cardiovascular Surgery, the ESC Council on Basic Cardiovascular Science, the ESC Scientists of Tomorrow, the European Association of Percutaneous Cardiovascular Interventions of the ESC, and the Heart Failure Association of the ESC Open
Animal models offer invaluable insights into disease mechanisms but cannot entirely mimic the variability and heterogeneity of human populations, nor the increasing prevalence of multi-morbidity. Consequently, employing human samples—such …
View article: Endothelial IGFBP6 suppresses vascular inflammation and atherosclerosis
Endothelial IGFBP6 suppresses vascular inflammation and atherosclerosis Open
View article: Zebrafish model for functional screening of flow-responsive genes controlling endothelial cell proliferation
Zebrafish model for functional screening of flow-responsive genes controlling endothelial cell proliferation Open
Local haemodynamics control arterial homeostasis and dysfunction by generating wall shear stress (WSS) which regulates endothelial cell (EC) physiology. Here we use a zebrafish model to identify genes that regulate EC proliferation in resp…
View article: Correction: Integrating particle tracking with computational fluid dynamics to assess haemodynamic perturbation by coronary artery stents
Correction: Integrating particle tracking with computational fluid dynamics to assess haemodynamic perturbation by coronary artery stents Open
[This corrects the article DOI: 10.1371/journal.pone.0271469.].
View article: Shear stress is uncoupled from atheroprotective KLK10 in atherosclerotic plaques
Shear stress is uncoupled from atheroprotective KLK10 in atherosclerotic plaques Open
Physiological shear stress is uncoupled from atheroprotective KLK10 within atherosclerotic plaques. This sheds light on the complex interplay between shear stress, endothelial function, and the progression of atherosclerosis in individuals…
View article: EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites Through Endothelial Fatty Acid Uptake
EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites Through Endothelial Fatty Acid Uptake Open
BACKGROUND: Atherosclerotic plaques form unevenly due to disturbed blood flow, causing localized endothelial cell (EC) dysfunction. Obesity exacerbates this process, but the underlying molecular mechanisms are unclear. The transcription fa…
View article: Endothelial MICU1 protects against vascular inflammation and atherosclerosis by inhibiting mitochondrial calcium uptake
Endothelial MICU1 protects against vascular inflammation and atherosclerosis by inhibiting mitochondrial calcium uptake Open
Atherosclerosis is triggered by endothelial activation and vascular inflammation, which is closely related to mitochondrial dysfunction. Mitochondrial calcium uptake 1 (MICU1), as the gatekeeper of mitochondrial Ca2+ homeostasis, is a crit…
View article: Controversy in mechanotransduction – the role of endothelial cell–cell junctions in fluid shear stress sensing
Controversy in mechanotransduction – the role of endothelial cell–cell junctions in fluid shear stress sensing Open
Fluid shear stress (FSS) from blood flow, sensed by the vascular endothelial cells (ECs) that line all blood vessels, regulates vascular development during embryogenesis, controls adult vascular physiology and determines the location of at…
View article: Sex-related differences in coronary and carotid vessel geometry, plaque composition and shear stress obtained from imaging
Sex-related differences in coronary and carotid vessel geometry, plaque composition and shear stress obtained from imaging Open
Atherosclerosis manifests itself differently in men and women with respect to plaque initiation, progression and plaque composition. The observed delay in plaque progression in women is thought to be related to the hormonal status of women…
View article: Assessing friction and damage of cell monolayers on soft substrates <i>in vitro</i>
Assessing friction and damage of cell monolayers on soft substrates <i>in vitro</i> Open
In the area of surgical applications, understanding the interaction between medical device materials and tissue is important since this interaction may cause complications. The interaction often consists of a cell monolayer touching the me…
View article: EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites through Endothelial Fatty Acid Uptake
EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites through Endothelial Fatty Acid Uptake Open
Background Atherosclerotic plaques form unevenly due to disturbed blood flow, causing localized endothelial cell (EC) dysfunction. Obesity exacerbates this process, but the underlying molecular mechanisms are unclear. The transcription fac…
View article: Editorial: Endothelial-to-mesenchymal transition in cardiovascular disease
Editorial: Endothelial-to-mesenchymal transition in cardiovascular disease Open
EDITORIAL article Front. Cardiovasc. Med., 12 October 2023Sec. Heart Valve Disease Volume 10 - 2023 | https://doi.org/10.3389/fcvm.2023.1290050
View article: Polymer biodegradation by<i>Halanaerobium</i>promotes reservoir souring during hydraulic fracturing
Polymer biodegradation by<i>Halanaerobium</i>promotes reservoir souring during hydraulic fracturing Open
Hydraulically fractured shale reservoirs have facilitated studies of unexplored niches in the continental deep biosphere. Members of the genus Halanaerobium are ubiquitous in these environments. Polymers like guar gum used as gelling agent…
View article: BS29 Endothelial TWIST1 enhances features of atherosclerotic plaque stability
BS29 Endothelial TWIST1 enhances features of atherosclerotic plaque stability Open
Atherosclerotic plaques progress towards instability and rupture, triggering myocardial infarction or stroke. Plaque instability is characterised by several features including reduced collagen content and increased inflammation. Disturbed…
View article: BS2 Flow-regulated EPAS1 limits atherosclerosis via metabolic control of endothelial proliferation
BS2 Flow-regulated EPAS1 limits atherosclerosis via metabolic control of endothelial proliferation Open
The transcription factor HIF1A is activated by disturbed blood flow in arteries and contributes to early atherosclerosis by promoting endothelial cell (EC) glycolysis and inflammation. The related molecule EPAS1 (HIF2A) co-operates with H…
View article: BS1 Polycystin-1 suppresses apoptotic signalling in endothelial cells and protects from atherosclerosis
BS1 Polycystin-1 suppresses apoptotic signalling in endothelial cells and protects from atherosclerosis Open
Introduction Haemodynamic wall shear stress (WSS) exerted on endothelial cells (ECs) by flowing blood determines the spatial distribution of atherosclerotic lesions. ECs are able to sense and respond to WSS thanks to mechanoreceptors on th…
View article: Correction to: EVA1A (Eva-1 Homolog A) Promotes Endothelial Apoptosis and Inflammatory Activation Under Disturbed Flow Via Regulation of Autophagy
Correction to: EVA1A (Eva-1 Homolog A) Promotes Endothelial Apoptosis and Inflammatory Activation Under Disturbed Flow Via Regulation of Autophagy Open
View article: EVA1A (Eva-1 Homolog A) Promotes Endothelial Apoptosis and Inflammatory Activation Under Disturbed Flow Via Regulation of Autophagy
EVA1A (Eva-1 Homolog A) Promotes Endothelial Apoptosis and Inflammatory Activation Under Disturbed Flow Via Regulation of Autophagy Open
Background: Hemodynamic wall shear stress (WSS) exerted on the endothelium by flowing blood determines the spatial distribution of atherosclerotic lesions. Disturbed flow (DF) with a low WSS magnitude and reversing direction promotes ather…
View article: Translational opportunities of single-cell biology in atherosclerosis
Translational opportunities of single-cell biology in atherosclerosis Open
The advent of single-cell biology opens a new chapter for understanding human biological processes and for diagnosing, monitoring, and treating disease. This revolution now reaches the field of cardiovascular disease (CVD). New technologie…
View article: JAG1-NOTCH4 mechanosensing drives atherosclerosis
JAG1-NOTCH4 mechanosensing drives atherosclerosis Open
Endothelial cell (EC) sensing of disturbed blood flow triggers atherosclerosis, a disease of arteries that causes heart attack and stroke, through poorly defined mechanisms. The Notch pathway plays a central role in blood vessel growth and…