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View article: NAMPT activity plays a key role in driving autoimmune processes that mediate beta-cell death and type 1 diabetes development in mice
NAMPT activity plays a key role in driving autoimmune processes that mediate beta-cell death and type 1 diabetes development in mice Open
Type 1 diabetes (T1D) is characterised by destruction of pancreatic beta-cells by islet-infiltrating cytotoxic lymphocytes, and elevated intra-islet secretion of pro-inflammatory cytokines. However, the underlying pathophysiological mechan…
View article: Carnosinase inhibition enhances reactive species scavenging in high fat diet
Carnosinase inhibition enhances reactive species scavenging in high fat diet Open
Our findings suggest that inhibition of carnosinase enzymes can increase the life-span, and thereby enhance the efficacy, of endogenous carnosine in vivo, thereby offering potential therapeutic benefits against obesity and other cardiometa…
View article: NAMPT activity plays a key role in driving autoimmune processes that characterise type 1 diabetes development in mice
NAMPT activity plays a key role in driving autoimmune processes that characterise type 1 diabetes development in mice Open
Type 1 diabetes (T1D) is characterised by destruction of pancreatic beta cells by islet-infiltrating cytotoxic lymphocytes, and elevated intra-islet secretion of pro-inflammatory cytokines. However, the underlying pathophysiological mechan…
View article: Molecular mechanisms linking type 2 diabetes mellitus and late-onset Alzheimer's disease: A systematic review and qualitative meta-analysis
Molecular mechanisms linking type 2 diabetes mellitus and late-onset Alzheimer's disease: A systematic review and qualitative meta-analysis Open
Research evidence indicating common metabolic mechanisms through which type 2 diabetes mellitus (T2DM) increases risk of late-onset Alzheimer's dementia (LOAD) has accumulated over recent decades. The aim of this systematic review is to pr…
View article: Characterisation of pomegranate juice polyphenols identifies oenothein B as an endothelium-dependent vasodilator and regulator of endothelial function that enhances actions of oligomeric procyanidins
Characterisation of pomegranate juice polyphenols identifies oenothein B as an endothelium-dependent vasodilator and regulator of endothelial function that enhances actions of oligomeric procyanidins Open
Background Cardiovascular disease mortality is reduced in individuals with high daily consumption of dietary polyphenols. Optimal daily intakes, choice of polyphenol, and mechanism of action have yet to be fully defined. Pomegranate juice …
View article: Modulation of sirtuins during monolayer chondrocyte culture influences cartilage regeneration upon transfer to a 3D culture environment
Modulation of sirtuins during monolayer chondrocyte culture influences cartilage regeneration upon transfer to a 3D culture environment Open
This study examined the role of sirtuins in the regenerative potential of articular chondrocytes. Sirtuins (SIRT1-7) play a key role in regulating cartilage homeostasis. By inhibiting pro-inflammatory pathways responsible for cartilage deg…
View article: The Histoire ancienne jusqu’à César: A Digital Edition (The Values of French)
The Histoire ancienne jusqu’à César: A Digital Edition (The Values of French) Open
The Histoire ancienne jusqu’à César: A Digital Edition, ed. by Hannah Morcos, Simon Gaunt, Simone Ventura, Maria Teresa Rachetta, Henry Ravenhall, Natasha Romanova, and Luca Barbieri; technical ed. Paul Caton, Ginestra Ferraro, Marcus Husa…
View article: The Histoire ancienne jusqu'à César: Alignment (The Values of French)
The Histoire ancienne jusqu'à César: Alignment (The Values of French) Open
Alignment maps the contents of a number of key manuscripts of the Histoire ancienne jusqu'à César, the earliest universal chronicle in French. The manuscripts are aligned to the paragraph division of the Histoire ancienne in Paris, Bibliot…
View article: The Histoire ancienne jusqu'à César: Lemmatisation and Search (The Values of French)
The Histoire ancienne jusqu'à César: Lemmatisation and Search (The Values of French) Open
The lemmatisation of The Histoire ancienne jusqu’à César: A Digital Edition is a key output of The Values of French. This dataset offers significant opportunities for linguistic and lexical analyses of medieval French.The latest version of…
View article: Carnosine protects stimulus-secretion coupling through prevention of protein carbonyl adduction events in cells under metabolic stress
Carnosine protects stimulus-secretion coupling through prevention of protein carbonyl adduction events in cells under metabolic stress Open
Type 2 diabetes is characterised by failure to control glucose homeostasis, with numerous diabetic complications attributable to the resulting exposure of cells and tissues to chronic elevated concentrations of glucose and fatty acids. Thi…
View article: The Histoire ancienne jusqu'à César: Lemmatisation and Search (The Values of French)
The Histoire ancienne jusqu'à César: Lemmatisation and Search (The Values of French) Open
The lemmatisation of The Histoire ancienne jusqu’à César: A Digital Edition is a key output of The Values of French. This dataset offers significant opportunities for linguistic and lexical analyses of medieval French.The latest version of…
View article: The Histoire ancienne jusqu’à César: A Digital Edition (The Values of French)
The Histoire ancienne jusqu’à César: A Digital Edition (The Values of French) Open
The Histoire ancienne jusqu’à César: A Digital Edition, ed. by Hannah Morcos, Simon Gaunt, Simone Ventura, Maria Teresa Rachetta, Henry Ravenhall, Natasha Romanova, and Luca Barbieri; technical ed. Paul Caton, Ginestra Ferraro, Marcus Husa…
View article: The Histoire ancienne jusqu'à César: Alignment (The Values of French)
The Histoire ancienne jusqu'à César: Alignment (The Values of French) Open
Alignment maps the contents of a number of key manuscripts of the Histoire ancienne jusqu'à César, the earliest universal chronicle in French. The manuscripts are aligned to the paragraph division of the Histoire ancienne in Paris, Bibliot…
View article: The Histoire ancienne jusqu'à César: Lemmatisation and Search (The Values of French)
The Histoire ancienne jusqu'à César: Lemmatisation and Search (The Values of French) Open
The lemmatisation of The Histoire ancienne jusqu’à César: A Digital Edition is a key output of The Values of French. This dataset offers significant opportunities for linguistic and lexical analyses of medieval French.The latest version of…
View article: Immunohistochemistry of Kidney a-SMA, Collagen 1, and Collagen 3, in A Novel Mouse Model of Reno-cardiac Syndrome
Immunohistochemistry of Kidney a-SMA, Collagen 1, and Collagen 3, in A Novel Mouse Model of Reno-cardiac Syndrome Open
Cardiorenal syndrome defines a synergistic pathology of the heart and kidneys where failure of one organ causes failure in the other. The incidence of cardiovascular mortality caused by this syndrome, is 20 fold higher in the end stage ren…
View article: The Histoire ancienne jusqu'à César: Alignment (The Values of French)
The Histoire ancienne jusqu'à César: Alignment (The Values of French) Open
Alignment maps the contents of a number of key manuscripts of the Histoire ancienne jusqu'à César, the earliest universal chronicle in French. The manuscripts are aligned to the paragraph division of the Histoire ancienne in Paris, Bibliot…
View article: The effects of betalain-rich cacti (dragon fruit and cactus pear) on endothelial and vascular function: a systematic review of animal and human studies
The effects of betalain-rich cacti (dragon fruit and cactus pear) on endothelial and vascular function: a systematic review of animal and human studies Open
This systematic review assesses the evidence for the effects of edible cacti (dragon fruit and cactus pear) on vascular and endothelial function based on animal models and human studies.
View article: The Histoire ancienne jusqu’à César: A Digital Edition (The Values of French)
The Histoire ancienne jusqu’à César: A Digital Edition (The Values of French) Open
The Histoire ancienne jusqu’à César: A Digital Edition, ed. by Hannah Morcos, Simon Gaunt, Simone Ventura, Maria Teresa Rachetta, Henry Ravenhall, Natasha Romanova, and Luca Barbieri; technical ed. Paul Caton, Ginestra Ferraro, Marcus Husa…
View article: Structure-functional changes in eNAMPT at high concentrations mediate mouse and human beta cell dysfunction in type 2 diabetes
Structure-functional changes in eNAMPT at high concentrations mediate mouse and human beta cell dysfunction in type 2 diabetes Open
Aims/hypothesis Progressive decline in functional beta cell mass is central to the development of type 2 diabetes. Elevated serum levels of extracellular nicotinamide phosphoribosyltransferase (eNAMPT) are associated with beta cell failure…
View article: Sensory nerves mediate spontaneous behaviors in addition to inflammation in a murine model of psoriasis
Sensory nerves mediate spontaneous behaviors in addition to inflammation in a murine model of psoriasis Open
Psoriasis is characterized by keratinocyte hyperproliferation, erythema, as well as a form of pruritus, involving cutaneous discomfort. There is evidence from both clinical and murine models of psoriasis that chemical or surgical depletion…
View article: Effect of betalain (betanin) supplementation on endothelial dysfunction and vascular tone in human umbilical vascular endothelial cells
Effect of betalain (betanin) supplementation on endothelial dysfunction and vascular tone in human umbilical vascular endothelial cells Open
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View article: Additional file 4: of A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain
Additional file 4: of A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain Open
Raw datasets. (XLSX 66 kb)
View article: Carnosine scavenging of glucolipotoxic free radicals enhances insulin secretion and glucose uptake
Carnosine scavenging of glucolipotoxic free radicals enhances insulin secretion and glucose uptake Open
The worldwide prevalence of diabetes has risen to 8.5% among adults, which represents a staggering rise in prevalence from 4.7% in 1980. Whilst some treatments work by increasing insulin secretion, over time their effectiveness decreases. …