Paul Chammas
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View article: CRISPRa-mediated disentanglement of the Dux-MERVL axis in the 2C-like state, totipotency, and cell death
CRISPRa-mediated disentanglement of the Dux-MERVL axis in the 2C-like state, totipotency, and cell death Open
Transposable elements (TEs) are powerful cis-regulatory drivers of gene expression, particularly during early development when many TEs become de-repressed. MERVL elements are transiently up-regulated in mouse totipotent two-cell (2C) embr…
View article: The PRC2-associated factor EPOP is required for Hox gene regulation during axial development in mice
The PRC2-associated factor EPOP is required for Hox gene regulation during axial development in mice Open
The Polycomb repressive complex 2 (PRC2) is an essential modulator of gene repression. We previously reported that, in mouse embryonic stem cells, PRC2 associates with elonginB/C through EPOP, which allows for low-level expression of targe…
View article: CRISPRa-mediated disentanglement of the Dux-MERVL axis in the 2C-like state, totipotency and cell death
CRISPRa-mediated disentanglement of the Dux-MERVL axis in the 2C-like state, totipotency and cell death Open
Transposable elements (TEs) provide sequences that are powerful cis-regulatory drivers of gene expression programmes. This is particularly apparent during early development when many TEs become de-repressed. MERVL elements are highly yet t…
View article: Nucleolar-based <i>Dux</i> repression is essential for embryonic two-cell stage exit
Nucleolar-based <i>Dux</i> repression is essential for embryonic two-cell stage exit Open
Upon fertilization, the mammalian embryo must switch from dependence on maternal transcripts to transcribing its own genome, and in mice this involves the transient up-regulation of MERVL transposons and MERVL-driven genes at the two-cell …
View article: Nucleolar-based <i>Dux</i> repression is essential for 2-cell stage exit
Nucleolar-based <i>Dux</i> repression is essential for 2-cell stage exit Open
Upon fertilisation, the mammalian embryo must switch from dependence on maternal transcripts to transcribing its own genome, and in mice involves the transient upregulation of MERVL transposons and MERVL-driven genes at the 2-cell stage. T…