Paul Dingwall
YOU?
Author Swipe
View article: Revealing the Mechanism of TEMPO-Hypervalent Iodine(III) Oxidation of Alcohols
Revealing the Mechanism of TEMPO-Hypervalent Iodine(III) Oxidation of Alcohols Open
This paper reports experimental and computational studies on the mechanism of a popular and well-known procedure for the oxidation of alcohols to carbonyl compounds using TEMPO and the hypervalent iodine reagent PIDA. Easy to obtain kineti…
View article: Oxidation of Alcohols and Aldehydes with Peracetic Acid and a Mn(II)/Pyridin‐2‐Carboxylato Catalyst: Substrate and Continuous Flow Studies
Oxidation of Alcohols and Aldehydes with Peracetic Acid and a Mn(II)/Pyridin‐2‐Carboxylato Catalyst: Substrate and Continuous Flow Studies Open
A homogeneous catalyst system consisting of Mn(OAc) 2 and 2‐picolinic acid was studied for alcohol oxidation using peracetic acid as the oxidant. Catalyst loadings as low as 0.01 mol% could be utilized and the system compared well to other…
View article: Enabling High Throughput Kinetic Experimentation by Using Flow as a Differential Kinetic Technique**
Enabling High Throughput Kinetic Experimentation by Using Flow as a Differential Kinetic Technique** Open
Kinetic data is most commonly collected through the generation of time‐series data under either batch or flow conditions. Existing methods to generate kinetic data in flow collect integral data (concentration over time) only. Here, we repo…
View article: Enabling High Throughput Kinetic Experimentation by Using Flow as a Differential Kinetic Technique**
Enabling High Throughput Kinetic Experimentation by Using Flow as a Differential Kinetic Technique** Open
Kinetic data is most commonly collected through the generation of time‐series data under either batch or flow conditions. Existing methods to generate kinetic data in flow collect integral data (concentration over time) only. Here, we repo…
View article: CCDC 2094910: Experimental Crystal Structure Determination
CCDC 2094910: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Enabling High Throughput Kinetic Experimentation by Using Flow as a Differential Kinetic Technique
Enabling High Throughput Kinetic Experimentation by Using Flow as a Differential Kinetic Technique Open
Kinetic data is most commonly collected through the generation of time-series data under either batch or flow conditions. Existing methods to generate kinetic data in flow collect integral data (concentration over time) only. Here, we repo…
View article: Continuous Flow Epoxidation of Alkenes Using a Homogeneous Manganese Catalyst with Peracetic Acid
Continuous Flow Epoxidation of Alkenes Using a Homogeneous Manganese Catalyst with Peracetic Acid Open
Epoxidation of alkenes is a valuable transformation in the synthesis of fine chemicals. Described herein are the design and development of a continuous flow process for carrying out the epoxidation of alkenes with a homogeneous manganese c…
View article: Continuous-flow transfer hydrogenation of benzonitrile using formate as a safe and sustainable source of hydrogen
Continuous-flow transfer hydrogenation of benzonitrile using formate as a safe and sustainable source of hydrogen Open
Demonstration of catalytic transfer hydrogenation of benzonitrile in flow using formate reducing agents.
View article: Enhancing the performance for palladium catalysed <i>tert</i>-butyl hydroperoxide-mediated Wacker-type oxidation of alkenes
Enhancing the performance for palladium catalysed <i>tert</i>-butyl hydroperoxide-mediated Wacker-type oxidation of alkenes Open
This work examines the palladium( ii ) catalysed oxidation of terminal alkenes to their corresponding methyl ketones using tert -butyl hydroperoxide (TBHP) as the oxidant.
View article: Investigating the mechanism and origins of selectivity in palladium-catalysed carbene insertion cross-coupling reactions
Investigating the mechanism and origins of selectivity in palladium-catalysed carbene insertion cross-coupling reactions Open
The mechanism of palladium-catalysed carbene insertion cross-coupling reactions has been experimentally and computationally studied, with carbene insertion identified as the likely selectivity determining step.
View article: Atropselective synthesis of <i>N</i>-aryl pyridones <i>via</i> dynamic kinetic resolution enabled by non-covalent interactions
Atropselective synthesis of <i>N</i>-aryl pyridones <i>via</i> dynamic kinetic resolution enabled by non-covalent interactions Open
Hydrogen bonding in ortho -phenols enables enantioselective synthesis of axially chiral 2-pyridones via dynamic kinetic resolution.
View article: Atroposelective Synthesis, Structure and Properties of a Novel Class of Axially Chiral <i>N</i>‐Aryl Quinolinium Salt
Atroposelective Synthesis, Structure and Properties of a Novel Class of Axially Chiral <i>N</i>‐Aryl Quinolinium Salt Open
Inspired by naturally occurring molecules containing atropisomeric N + ‐C axes, we have developed a novel synthetic approach to generate a library of axially chiral N ‐aryl quinolinium salts. Enantiopurities up to 93 % ee were obtained via…
View article: Chiral, sequence-definable foldamer-derived macrocycles
Chiral, sequence-definable foldamer-derived macrocycles Open
Dipole-controlled pre-organization enables the cyclization of sequence-defined foldamers into macrocycles. The structure and properties of trimeric and tetrameric macrocycles are explored, and their ability to bind cationic guests is demon…
View article: Understanding Catalyst Structure–Selectivity Relationships in Pd-Catalyzed Enantioselective Methoxycarbonylation of Styrene
Understanding Catalyst Structure–Selectivity Relationships in Pd-Catalyzed Enantioselective Methoxycarbonylation of Styrene Open
The EPSRC are thanked for funding PD and JAF in the very early stages of this work (EP/M003868/1).
View article: Data supporting "Photochemical homologation for the preparation of aliphatic aldehydes in flow"
Data supporting "Photochemical homologation for the preparation of aliphatic aldehydes in flow" Open
NMR documents for Photochemical homologation for the preparation of aliphatic aldehydes in flow
View article: CO‐Free Enantioselective Hydroformylation of Functionalised Alkenes: Using a Dual Catalyst System to Give Improved Selectivity and Yield
CO‐Free Enantioselective Hydroformylation of Functionalised Alkenes: Using a Dual Catalyst System to Give Improved Selectivity and Yield Open
The scope of carbon monoxide‐free Asymmetric Transfer HydroFormylation (ATHF) procedures using a highly active single catalyst system derived from 1,2‐bis‐((2,5)‐diphenylphospholano)ethane as chiral ligand has been studied. This reveals so…
View article: Fast continuous alcohol amination employing a hydrogen borrowing protocol
Fast continuous alcohol amination employing a hydrogen borrowing protocol Open
A continuous flow method for the direct conversion of alcohols to amines via a hydrogen borrowing approach is reported.