Paul S. Donnelly
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View article: Front Cover: Ar–X Coupling Reactions of Cationic Aryl Copper(II) Complexes with Organic Substrates: What Role Do Radicals Play?
Front Cover: Ar–X Coupling Reactions of Cationic Aryl Copper(II) Complexes with Organic Substrates: What Role Do Radicals Play? Open
View article: Collagen-targeted tracers for molecular imaging of atrial fibrosis and sensitive detection of atrial fibrillation
Collagen-targeted tracers for molecular imaging of atrial fibrosis and sensitive detection of atrial fibrillation Open
Atrial fibrillation (AF), often accompanied by atrial fibrosis, is challenging to diagnose sub-clinically and reverse once established. Molecular imaging targeting excess atrial collagen may enable earlier detection of atrial fibrosis and …
View article: Ar–X Coupling Reactions of Cationic Aryl Copper(II) Complexes with Organic Substrates: What Role Do Radicals Play?
Ar–X Coupling Reactions of Cationic Aryl Copper(II) Complexes with Organic Substrates: What Role Do Radicals Play? Open
Copper(II) aryl species are proposed intermediates in copper catalysed C‐X coupling reactions. Here, the formation and reactions of the cationic copper complexes [(phen)Cu(Ar)] + (phen = 1,10‐phenanthroline; Ar = Ph, p ‐MeC 6 H 4 , p ‐MeOC…
View article: Factors which influence young people’s experience of gaelic games. A secondary analysis of results from a large cross-sectional national study
Factors which influence young people’s experience of gaelic games. A secondary analysis of results from a large cross-sectional national study Open
Enjoyment of sport is an important factor in preventing dropout or drop off. Using a cross-sectional design, and a sample of 4,594 Gaelic games players (aged 13 to 20), the present study was a secondary analysis, examining which factors (i…
View article: Heart–brain microvascular MRI study: protocol for a multicentre, observational, cohort study in the UK assessing associations between small vessel disease of the heart and brain
Heart–brain microvascular MRI study: protocol for a multicentre, observational, cohort study in the UK assessing associations between small vessel disease of the heart and brain Open
Introduction Ischaemic heart disease (IHD) and cerebrovascular disease are leading causes of morbidity and mortality worldwide. Cerebral small vessel disease (CSVD) is a leading cause of dementia and stroke. While coronary small vessel dis…
View article: Preclinical evaluation and automated synthesis of [89Zr]ZrDFOSquaramide-girentuximab for diagnostic imaging of carbonic anhydrase IX positive tumours
Preclinical evaluation and automated synthesis of [89Zr]ZrDFOSquaramide-girentuximab for diagnostic imaging of carbonic anhydrase IX positive tumours Open
View article: Integrated elemental analysis supports targeting copper perturbations as a therapeutic strategy in multiple sclerosis
Integrated elemental analysis supports targeting copper perturbations as a therapeutic strategy in multiple sclerosis Open
View article: Automated synthesis of [89Zr]ZrCl4, [89Zr]ZrDFOSquaramide-bisPh(PSMA) and [89Zr]ZrDFOSquaramide-TATE
Automated synthesis of [89Zr]ZrCl4, [89Zr]ZrDFOSquaramide-bisPh(PSMA) and [89Zr]ZrDFOSquaramide-TATE Open
View article: Molecular Imaging of Diffuse Cardiac Fibrosis with a Radiotracer That Targets Proteolyzed Collagen IV
Molecular Imaging of Diffuse Cardiac Fibrosis with a Radiotracer That Targets Proteolyzed Collagen IV Open
Purpose To develop an approach for in vivo detection of interstitial cardiac fibrosis using PET with a peptide tracer targeting proteolyzed collagen IV (T-peptide). Materials and Methods T-peptide was conjugated to the copper chelator MeCO…
View article: Evidence for disrupted copper availability in human spinal cord supports CuII(atsm) as a treatment option for sporadic cases of ALS
Evidence for disrupted copper availability in human spinal cord supports CuII(atsm) as a treatment option for sporadic cases of ALS Open
The copper compound Cu II (atsm) has progressed to phase 2/3 testing for treatment of the neurodegenerative disease amyotrophic lateral sclerosis (ALS). Cu II (atsm) is neuroprotective in mutant SOD1 mouse models of ALS where its activity …
View article: Microglial ferroptotic stress causes non-cell autonomous neuronal death
Microglial ferroptotic stress causes non-cell autonomous neuronal death Open
Background Ferroptosis is a form of regulated cell death characterised by lipid peroxidation as the terminal endpoint and a requirement for iron. Although it protects against cancer and infection, ferroptosis is also implicated in causing …
View article: Tumor targeted alpha particle therapy with an actinium-225 labelled antibody for carbonic anhydrase IX
Tumor targeted alpha particle therapy with an actinium-225 labelled antibody for carbonic anhydrase IX Open
Alpha particle therapy with an actinium-225 labelled antibody for carbonic anhydrase IX leads to a highly significant therapeutic response in a mouse xenograft model.
View article: Evidence for decreased copper associated with demyelination in the corpus callosum of cuprizone-treated mice
Evidence for decreased copper associated with demyelination in the corpus callosum of cuprizone-treated mice Open
Demyelination within the central nervous system (CNS) is a significant feature of debilitating neurological diseases such as multiple sclerosis and administering the copper-selective chelatorcuprizone to mice is widely used to model demyel…
View article: Similarities and Differences of Youth Males and Females Experiences in Organized Sport: A Case Study of Gaelic Games
Similarities and Differences of Youth Males and Females Experiences in Organized Sport: A Case Study of Gaelic Games Open
Consistently, in different contexts, young males are more likely to play organized sport than young females. The purpose of this analysis is to describe how young males and females engage in organized sport, using a cross-sectional sample …
View article: A patient-derived blood-brain barrier model for screening copper bis(thiosemicarbazone) complexes as potential therapeutics in Alzheimer’s disease
A patient-derived blood-brain barrier model for screening copper bis(thiosemicarbazone) complexes as potential therapeutics in Alzheimer’s disease Open
Alzheimer’s disease (AD) is the most prevalent cause of dementia characterised by progressive cognitive decline. Addressing neuroinflammation represents a promising therapeutic avenue to treat AD, however, the development of effective anti…
View article: CCDC 2249877: Experimental Crystal Structure Determination
CCDC 2249877: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2280765: Experimental Crystal Structure Determination
CCDC 2280765: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2280763: Experimental Crystal Structure Determination
CCDC 2280763: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2224866: Experimental Crystal Structure Determination
CCDC 2224866: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2280766: Experimental Crystal Structure Determination
CCDC 2280766: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2249879: Experimental Crystal Structure Determination
CCDC 2249879: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2205204: Experimental Crystal Structure Determination
CCDC 2205204: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2280764: Experimental Crystal Structure Determination
CCDC 2280764: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2249876: Experimental Crystal Structure Determination
CCDC 2249876: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2249878: Experimental Crystal Structure Determination
CCDC 2249878: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2252368: Experimental Crystal Structure Determination
CCDC 2252368: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2252366: Experimental Crystal Structure Determination
CCDC 2252366: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2252367: Experimental Crystal Structure Determination
CCDC 2252367: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2252369: Experimental Crystal Structure Determination
CCDC 2252369: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Cu(ATSM) Increases P-Glycoprotein Expression and Function at the Blood-Brain Barrier in C57BL6/J Mice
Cu(ATSM) Increases P-Glycoprotein Expression and Function at the Blood-Brain Barrier in C57BL6/J Mice Open
P-glycoprotein (P-gp), expressed at the blood-brain barrier (BBB), is critical in preventing brain access to substrate drugs and effluxing amyloid beta (Aβ), a contributor to Alzheimer’s disease (AD). Strategies to regulate P-gp expression…