Paul Frewen
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View article: Study protocol for a multi-session randomized sham-controlled trial of PCC- and amygdala-targeted neurofeedback for the treatment of PTSD
Study protocol for a multi-session randomized sham-controlled trial of PCC- and amygdala-targeted neurofeedback for the treatment of PTSD Open
View article: Alpha rhythm transcranial electrical stimulation to inferior parietal cortex increases alpha power and phase synchrony while attending to mind–body self-states
Alpha rhythm transcranial electrical stimulation to inferior parietal cortex increases alpha power and phase synchrony while attending to mind–body self-states Open
Self-referential processing (SRP) refers to the human brain's response to semantic and somatic self-related information. Recent developments in modulating semantic and somatic SRP using non-invasive brain stimulation supported the efficacy…
View article: Presence in time: watching live and recorded sports in VR increases spatial, interpersonal, and temporal presence
Presence in time: watching live and recorded sports in VR increases spatial, interpersonal, and temporal presence Open
Introduction Little research has explored the experience of viewing sporting events in three-dimensional (3D) virtual reality (VR), whether at the time the sporting events are happening or at a later date. Materials and Methods Participant…
View article: A tale of two targets: examining the differential effects of posterior cingulate cortex- and amygdala-targeted fMRI-neurofeedback in a PTSD pilot study
A tale of two targets: examining the differential effects of posterior cingulate cortex- and amygdala-targeted fMRI-neurofeedback in a PTSD pilot study Open
Introduction Real-time fMRI-based neurofeedback (rt-fMRI-NFB) is a non-invasive technology that enables individuals to self-regulate brain activity linked to neuropsychiatric symptoms, including those associated with post-traumatic stress …
View article: The Human Affectome
The Human Affectome Open
View article: A randomized controlled trial of Deep Brain Reorienting: a neuroscientifically guided treatment for post-traumatic stress disorder
A randomized controlled trial of Deep Brain Reorienting: a neuroscientifically guided treatment for post-traumatic stress disorder Open
These findings provide emerging evidence for the effectiveness of DBR as a well-tolerated treatment that is based on theoretical advances highlighting alterations to subcortical mechanisms in PTSD and associated symptomatology. Additional …
View article: Being where, with whom, and when it happens: spatial, interpersonal, and temporal presence while viewing live streaming of collegiate sports in virtual reality
Being where, with whom, and when it happens: spatial, interpersonal, and temporal presence while viewing live streaming of collegiate sports in virtual reality Open
Introduction: Although virtual reality (VR) is most popularly known for its applications to gaming, other entertainment applications are increasingly being explored including in the sports media industry, but little research has so far exa…
View article: Homeostatic normalization of alpha brain rhythms within the default-mode network and reduced symptoms in post-traumatic stress disorder following a randomized controlled trial of electroencephalogram neurofeedback
Homeostatic normalization of alpha brain rhythms within the default-mode network and reduced symptoms in post-traumatic stress disorder following a randomized controlled trial of electroencephalogram neurofeedback Open
Collective research has identified a key electroencephalogram signature in patients with post-traumatic stress disorder, consisting of abnormally reduced alpha (8–12 Hz) rhythms. We conducted a 20-session, double-blind, randomized controll…
View article: Posterior cingulate cortex targeted real‐time fMRI neurofeedback recalibrates functional connectivity with the amygdala, posterior insula, and default‐mode network in PTSD
Posterior cingulate cortex targeted real‐time fMRI neurofeedback recalibrates functional connectivity with the amygdala, posterior insula, and default‐mode network in PTSD Open
Background Alterations within large‐scale brain networks—namely, the default mode (DMN) and salience networks (SN)—are present among individuals with posttraumatic stress disorder (PTSD). Previous real‐time functional magnetic resonance im…
View article: Restoring large-scale brain networks in PTSD and related disorders: a proposal for neuroscientifically-informed treatment interventions
Restoring large-scale brain networks in PTSD and related disorders: a proposal for neuroscientifically-informed treatment interventions Open
Three intrinsic connectivity networks in the brain, namely the central executive, salience, and default mode networks, have been identified as crucial to the understanding of higher cognitive functioning, and the functioning of these netwo…
View article: Latent profile analysis and principal axis factoring of the DSM-5 dissociative subtype
Latent profile analysis and principal axis factoring of the DSM-5 dissociative subtype Open
A dissociative subtype has been recognized based on the presence of experiences of depersonalization and derealization in relation to DSM-IV posttraumatic stress disorder (PTSD). However, the dissociative subtype has not been assessed in a…
View article: Lifetime traumatic stressors and adverse childhood experiences uniquely predict concurrent PTSD, complex PTSD, and dissociative subtype of PTSD symptoms whereas recent adult non-traumatic stressors do not: results from an online survey study
Lifetime traumatic stressors and adverse childhood experiences uniquely predict concurrent PTSD, complex PTSD, and dissociative subtype of PTSD symptoms whereas recent adult non-traumatic stressors do not: results from an online survey study Open
This retrospective survey study compared the differential risk of lifetime traumatic stressors, so-called “non-traumatic stressors” experienced over the past year, referring to life events that do not meet the criteria for A1 traumatic eve…
View article: Assessing the family dynamics of childhood maltreatment history with the Childhood Attachment and Relational Trauma Screen (CARTS)
Assessing the family dynamics of childhood maltreatment history with the Childhood Attachment and Relational Trauma Screen (CARTS) Open
Existing survey measures of childhood trauma history generally fail to take into account the relational-socioecological environment in which childhood maltreatment occurs. Variables such as the relationship between the perpetrator and the …
View article: Moral reasoning in women with posttraumatic stress disorder related to childhood abuse
Moral reasoning in women with posttraumatic stress disorder related to childhood abuse Open
Preliminary evidence suggests that relative to healthy controls, patients with posttraumatic stress disorder (PTSD) show deficits on several inter-related social cognitive tasks, including theory of mind, and emotion comprehension. Systema…
View article: Trauma-related altered states of consciousness in women with BPD with or without co-occurring PTSD
Trauma-related altered states of consciousness in women with BPD with or without co-occurring PTSD Open
A “4-D model” was recently described as a theoretical framework for categorizing trauma-related symptoms into four phenomenological dimensions (the experience of time, thought, body, and emotion) that can present either in the form of norm…
View article: Increased top-down control of emotions during symptom provocation working memory tasks following a RCT of alpha-down neurofeedback in PTSD
Increased top-down control of emotions during symptom provocation working memory tasks following a RCT of alpha-down neurofeedback in PTSD Open
This is the first study to provide mechanistic insights into how NFB may normalize dysfunctional brain activity and connectivity in PTSD under cognitive load with simultaneous symptom provocation, adding to a growing body of evidence suppo…
View article: Large-Scale Functional Hyperconnectivity Patterns Characterizing Trauma-Related Dissociation: A rs-fMRI Study of PTSD and its Dissociative Subtype
Large-Scale Functional Hyperconnectivity Patterns Characterizing Trauma-Related Dissociation: A rs-fMRI Study of PTSD and its Dissociative Subtype Open
The dissociative subtype of post-traumatic stress disorder (PTSD) is a distinct PTSD phenotype characterized by trauma-related dissociation, alongside unique patterns of small and large-scale functional connectivity. However, disparate fin…
View article: The Human Affectome
The Human Affectome Open
Over the last decades, the interdisciplinary field of the affective sciences has seen proliferation rather than integration of theoretical perspectives. This is due to differences in metaphysical and mechanistic assumptions about human aff…
View article: The Human Affectome
The Human Affectome Open
Over the last decades, the interdisciplinary field of the affective sciences has seen proliferation rather than integration of theoretical perspectives. This is due to differences in metaphysical and mechanistic assumptions about human aff…
View article: Sense of self in mind and body: an eLORETA-EEG study
Sense of self in mind and body: an eLORETA-EEG study Open
The human brain engages the sense of self through both semantic and somatic self-referential processing (SRP). Alpha and theta oscillations have been found to underlie SRP but have not been compared with respect to semantic and somatic SRP…
View article: Differential mechanisms of posterior cingulate cortex downregulation and symptom decreases in posttraumatic stress disorder and healthy individuals using real‐time fMRI neurofeedback
Differential mechanisms of posterior cingulate cortex downregulation and symptom decreases in posttraumatic stress disorder and healthy individuals using real‐time fMRI neurofeedback Open
Background Intrinsic connectivity networks, including the default mode network (DMN), are frequently disrupted in individuals with posttraumatic stress disorder (PTSD). The posterior cingulate cortex (PCC) is the main hub of the posterior …
View article: Author response for "Differential mechanisms of posterior cingulate cortex downregulation and symptom decreases in posttraumatic stress disorder and healthy individuals using real‐time fMRI neurofeedback"
Author response for "Differential mechanisms of posterior cingulate cortex downregulation and symptom decreases in posttraumatic stress disorder and healthy individuals using real‐time fMRI neurofeedback" Open
View article: Self-Referential Processing Effects of Non-invasive Brain Stimulation: A Systematic Review
Self-Referential Processing Effects of Non-invasive Brain Stimulation: A Systematic Review Open
Systematic reviews of neuroimaging studies confirm stimulus-induced activity in response to verbal and non-verbal self-referential processing (SRP) in cortical midline structures, temporoparietal cortex and insula. Whether SRP can be causa…
View article: Validation and cross-cultural comparisons of the German Childhood Attachment and Relational Trauma Screen (CARTS) Validación y comparaciones transculturales del Tamizaje de Apego y Trauma Relacional de la Infancia (CARTS) en Alemán 德语版童年期依恋和关系性创伤筛查 (CARTS) 的验证和跨文化比较
Validation and cross-cultural comparisons of the German Childhood Attachment and Relational Trauma Screen (CARTS) Validación y comparaciones transculturales del Tamizaje de Apego y Trauma Relacional de la Infancia (CARTS) en Alemán 德语版童年期依恋和关系性创伤筛查 (CARTS) 的验证和跨文化比较 Open
View article: Meditating in Virtual Reality 3: 360° Video of Perceptual Presence of Instructor
Meditating in Virtual Reality 3: 360° Video of Perceptual Presence of Instructor Open
View article: Restoring large scale brain networks in the aftermath of trauma: implications for neuroscientifically-informed treatments
Restoring large scale brain networks in the aftermath of trauma: implications for neuroscientifically-informed treatments Open
Background: Several intrinsic networks in the brain, including the default mode network, the salience network, and the central executive network, have shown to be critical to higher cognitive functioning. Importantly, these networks have b…
View article: Lifetime traumatic stressors and adverse childhood experiences uniquely predict concurrent PTSD, complex PTSD, and dissociative subtype of PTSD symptoms whereas recent adult non-traumatic stressors do not: results from an online survey study
Lifetime traumatic stressors and adverse childhood experiences uniquely predict concurrent PTSD, complex PTSD, and dissociative subtype of PTSD symptoms whereas recent adult non-traumatic stressors do not: results from an online survey study Open
This retrospective survey study compared the differential risk of lifetime traumatic stressors, so-called “non-traumatic stressors” experienced over the past year, referring to life events that do not meet the criteria for A1 traumatic eve…
View article: Validation and cross-cultural comparisons of the German Childhood Attachment and Relational Trauma Screen (CARTS)
Validation and cross-cultural comparisons of the German Childhood Attachment and Relational Trauma Screen (CARTS) Open
Background: Child maltreatment is embedded in a complex system of familial, societal and cultural influences. However, the microsystemic framework in which child maltreatment occurs has not been sufficiently accounted for in previou…
View article: Global Psychotrauma Screen (GPS): psychometric properties in two Internet-based studies
Global Psychotrauma Screen (GPS): psychometric properties in two Internet-based studies Open
Background: Potentially traumatic stressors can lead to various transdiagnostic outcomes beyond PTSD alone but no brief screening tools exist for measuring posttraumatic responses in a transdiagnostic manner. Objective: Asses…
View article: Peripersonal Space and Bodily Self-Consciousness: Implications for Psychological Trauma-Related Disorders
Peripersonal Space and Bodily Self-Consciousness: Implications for Psychological Trauma-Related Disorders Open
Peripersonal space (PPS) is defined as the space surrounding the body where we can reach or be reached by external entities, including objects or other individuals. PPS is an essential component of bodily self-consciousness that allows us …