Paul G. Werthmann
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View article: Efficacy and safety of massage for postoperative stress in colorectal cancer patients: a randomized, controlled, three-arm trial
Efficacy and safety of massage for postoperative stress in colorectal cancer patients: a randomized, controlled, three-arm trial Open
Purpose The purpose of this study was to investigate the effect of rhythmic embrocation (RE), a massage technique, on postoperative stress levels (measured by heart rate variability) in colorectal cancer surgery patients compared to empath…
View article: PRIO – a prospective integrative oncology registry: trial protocol
PRIO – a prospective integrative oncology registry: trial protocol Open
Background Integrative Oncology (IO) – the use of lifestyle modifications, mind-body practices and natural products in oncology – is increasingly asked for by patients. The evidence base of IO is growing and IO measures are included in nat…
View article: The Impact of Surgery-Related Emotional Distress on Long-Term Outcome After Colorectal Surgery: An Observational Follow-Up
The Impact of Surgery-Related Emotional Distress on Long-Term Outcome After Colorectal Surgery: An Observational Follow-Up Open
Background: Preoperative emotional distress has been linked to adverse health outcomes, diminished quality of life, increased symptom burden after surgery, and poorer postoperative outcomes. Therefore, this study aimed to assess the impact…
View article: RECOVARI – Postoperative massage in colorectal cancer patients: a randomized controlled, three-arm parallel group trial
RECOVARI – Postoperative massage in colorectal cancer patients: a randomized controlled, three-arm parallel group trial Open
Purpose : This study aimed to investigate the impact of Rhythmical Embrocation (RE), a massage technique, on postoperative stress levels of colorectal cancer surgery patients compared to empathic conversation. Methods : The study included …
View article: CARE Guidelines for Case Reports: Explanation and Elaboration Document. Translation into Russian
CARE Guidelines for Case Reports: Explanation and Elaboration Document. Translation into Russian Open
Background . Well-written and transparent case reports (1) reveal early signals of potential benefits, harms, and information on the use of resources; (2) provide information for clinical research and clinical practice guidelines, and (3) …
View article: Surgery as an Emotional Strain: An Observational Study in Patients Undergoing Elective Colorectal Surgery
Surgery as an Emotional Strain: An Observational Study in Patients Undergoing Elective Colorectal Surgery Open
Recent research suggests an impact of psychological distress on postoperative outcomes in orthopedic and neurosurgery. It is widely unknown whether patients’ mood might affect the postoperative outcome and complication rate in colorectal s…
View article: CARE guidelines for case reports: explanation and elaboration document. Translation into Russian
CARE guidelines for case reports: explanation and elaboration document. Translation into Russian Open
BACKGROUND: Well-written and transparent case reports (1) reveal early signals of potential benefits, harms, and information on the use of resources; (2) provide information for clinical research and clinical practice guidelines, and (3) i…
View article: RECOVARI – Efficacy and Safety of Massage on Surgical Stress in Colorectal Cancer Patients: Study Protocol for A Randomized Controlled, Three-Arm Parallel Group, Clinical Trial
RECOVARI – Efficacy and Safety of Massage on Surgical Stress in Colorectal Cancer Patients: Study Protocol for A Randomized Controlled, Three-Arm Parallel Group, Clinical Trial Open
• Background : Patients’ physiological stress reactions to surgery have been ameliorated by refining surgical techniques, and improving pain therapy. Moreover, another way to reduce stress could be the use of Rhythmical embrocation (RE), a…
View article: Addressing COVID-19 challenges in a randomised controlled trial on exercise interventions in a high-risk population
Addressing COVID-19 challenges in a randomised controlled trial on exercise interventions in a high-risk population Open
View article: Long-Term Survival of a Patient with Recurrent Dedifferentiated High-Grade Liposarcoma of the Retroperitoneum Under Adjuvant Treatment with <i>Viscum album</i> L. Extract: A Case Report
Long-Term Survival of a Patient with Recurrent Dedifferentiated High-Grade Liposarcoma of the Retroperitoneum Under Adjuvant Treatment with <i>Viscum album</i> L. Extract: A Case Report Open
Retroperitoneal sarcomas are rare. Dedifferentiated liposarcomas (DDLs) are high-grade tumors with a high propensity for local recurrence and metastasis and are associated with reduced survival. Radical resection remains the standard treat…
View article: Addressing COVID-19 Challenges in a Randomized Controlled Trial on Exercise Interventions in a High-risk Population
Addressing COVID-19 Challenges in a Randomized Controlled Trial on Exercise Interventions in a High-risk Population Open
Background: The coronavirus disease 2019 (COVID-19) pandemic is a threat to ongoing clinical trials necessitating regular face-to-face, in-person meetings, particularly in participants with a high risk of complications. Guidance on how to …
View article: Addressing COVID-19 Challenges in a Randomized Controlled Trial on Exercise Interventions in a High-Risk Population
Addressing COVID-19 Challenges in a Randomized Controlled Trial on Exercise Interventions in a High-Risk Population Open
Background: The coronavirus disease 2019 (COVID-19) pandemic is a threat to ongoing clinical trials necessitating regular face-to-face, in-person meetings, particularly in participants with a high risk of complications. Guidance on how to …
View article: CARE for COVID-19: A Checklist for Documentation of Coronavirus Disease 2019 Case Reports and Case Series
CARE for COVID-19: A Checklist for Documentation of Coronavirus Disease 2019 Case Reports and Case Series Open
Coronavirus disease 2019 (COVID-19) is a new, rapidly spreading pandemic that can lead to a life-threatening disease. Accurate and transparent COVID-19 case reports provide systematic clinical observations supporting researchers designing …
View article: A multi-centre, parallel-group, randomised controlled trial to assess the efficacy and safety of eurythmy therapy and tai chi in comparison with standard care in chronically ill elderly patients with increased risk of falling (ENTAiER): a trial protocol
A multi-centre, parallel-group, randomised controlled trial to assess the efficacy and safety of eurythmy therapy and tai chi in comparison with standard care in chronically ill elderly patients with increased risk of falling (ENTAiER): a trial protocol Open
View article: Long-term survival of a patient with an inoperable thymic neuroendocrine tumor stage IIIa under sole treatment with Viscum album extract
Long-term survival of a patient with an inoperable thymic neuroendocrine tumor stage IIIa under sole treatment with Viscum album extract Open
Rationale Thymic neuroendocrine tumor (TNET) is very rare and characterized by a tendency to invade adjacent structures, frequent metastasis, resistance to therapy, and a poor prognosis. Viscum album extracts (VAE) have shown immunological…
View article: Bilateral Asynchronous Renal Cell Carcinoma With Lung Metastases: A Case Report of a Patient Treated Solely With High-dose Intravenous and Subcutaneous <i>Viscum album</i> Extract for a Second Renal Lesion
Bilateral Asynchronous Renal Cell Carcinoma With Lung Metastases: A Case Report of a Patient Treated Solely With High-dose Intravenous and Subcutaneous <i>Viscum album</i> Extract for a Second Renal Lesion Open
As far as we are aware of, this is the first report of a patient with metastatic RCC with an RCC lesion of the second kidney treated solely with high-dose intravenous and subcutaneous VAE, associated with 2.5 years of progression-free surv…
View article: Long-term survival of a patient with advanced pancreatic cancer under adjunct treatment with <i>Viscum album</i> extracts: A case report
Long-term survival of a patient with advanced pancreatic cancer under adjunct treatment with <i>Viscum album</i> extracts: A case report Open
We present the case of a patient with aPC with R1-resection with development of liver metastasis during the course of treatment who showed an overall survival of 63 mo and a relapse-free survival of 39 mo under increasing VAE therapy. The …
View article: ERRATUM TO: Long-Term Tumor-Free Survival in a Patient with Stage IV Epithelial Ovarian Cancer Undergoing High-Dose Chemotherapy and Viscum album Extract Treatment: A Case Report
ERRATUM TO: Long-Term Tumor-Free Survival in a Patient with Stage IV Epithelial Ovarian Cancer Undergoing High-Dose Chemotherapy and Viscum album Extract Treatment: A Case Report Open
The original
View article: Chemoimmunotherapy in Advanced Renal Cell Carcinoma: A Case Report of a Long-Term Survivor Adjunctly Treated with Viscum album Extracts
Chemoimmunotherapy in Advanced Renal Cell Carcinoma: A Case Report of a Long-Term Survivor Adjunctly Treated with Viscum album Extracts Open
Introduction: Metastatic renal cell carcinoma has a poor prognosis. Treatment approaches with immunotherapy show promising results in subpopulations. Viscum album extracts – used as an adjunct to cancer treatment – hav…
View article: Long-Term Tumor-Free Survival in a Patient with Stage IV Epithelial Ovarian Cancer Undergoing High-Dose Chemotherapy and <i>Viscum album</i> Extract Treatment: A Case Report
Long-Term Tumor-Free Survival in a Patient with Stage IV Epithelial Ovarian Cancer Undergoing High-Dose Chemotherapy and <i>Viscum album</i> Extract Treatment: A Case Report Open
Treatment with VAE in this case might have contributed to the reduction of side effects from HDC and may have acted synergistically with HDC in tumor control. Cases of VAE in EOC should be carefully documented and reported to further illus…
View article: Long-term tumor-free survival in a metastatic pancreatic carcinoma patient with FOLFIRINOX/Mitomycin, high-dose, fever inducing Viscum album extracts and subsequent R0 resection
Long-term tumor-free survival in a metastatic pancreatic carcinoma patient with FOLFIRINOX/Mitomycin, high-dose, fever inducing Viscum album extracts and subsequent R0 resection Open
Rationale: Metastatic pancreatic cancer has a dismal prognosis. Many patients seek integrative care as an add-on to their conventional cancer treatment. Viscum album extracts (VAE)—widely used as an adjunct to cancer treatment—have cytotox…
View article: Intralesional and subcutaneous application of Viscum album L. (European mistletoe) extract in cervical carcinoma in situ
Intralesional and subcutaneous application of Viscum album L. (European mistletoe) extract in cervical carcinoma in situ Open
Rationale: Carcinoma in situ (CIS) of the uterine cervix is a premalignant condition of squamous epithelium. The standard treatments are excision and ablation procedures; for women with positive margins, hysterectomy is recommended. Patien…
View article: Complete Remission and Long-term Survival of a Patient with a Diffuse Large B-cell Lymphoma Under <i>Viscum album</i> Extracts After Resistance to R-CHOP: A Case Report
Complete Remission and Long-term Survival of a Patient with a Diffuse Large B-cell Lymphoma Under <i>Viscum album</i> Extracts After Resistance to R-CHOP: A Case Report Open
As complete remission of lymphoproliferative disorders after VAE treatment has been previously reported, further investigations of VAE in lymphoma seem highly worthwhile.
View article: Durable clinical remission of a skull metastasis under intralesional Viscum album extract therapy: Case report
Durable clinical remission of a skull metastasis under intralesional Viscum album extract therapy: Case report Open
Background Skull metastases are rare, they can eventually cause pain, and can invade the brain. Viscum album extracts (VAEs) are used as an adjuvant treatment in cancer. Methods and Results A 68‐year‐old patient with rectal cancer presente…
View article: A 21-year course of Merkel cell carcinoma with adjuvant Viscum album extract treatment: A case report
A 21-year course of Merkel cell carcinoma with adjuvant Viscum album extract treatment: A case report Open
View article: Minor regression and long-time survival (56 months) in a patient with malignant pleural mesothelioma under Viscum album and Helleborus niger extracts—a case report
Minor regression and long-time survival (56 months) in a patient with malignant pleural mesothelioma under Viscum album and Helleborus niger extracts—a case report Open
Malignant pleural mesothelioma (MPM) is a rare cancer with a dismal prognosis. Viscum album extracts (VAE) have strong immune stimulatory properties, cytotoxic effects, can downregulate cancer genes and inhibit angiogenesis. VAE are often …
View article: Complete remission and long-term survival of a patient with melanoma metastases treated with high-dose fever-inducing Viscum album extract
Complete remission and long-term survival of a patient with melanoma metastases treated with high-dose fever-inducing Viscum album extract Open
We presume that VAE triggered an increased release of tumor-associated antigens, enhanced immunologic recognition, and increased immune response against the tumor tissue and induced tumor remission.