Paul J. Gane
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View article: Therapeutic Validation of GEF-H1 Using a De Novo Designed Inhibitor in Models of Retinal Disease
Therapeutic Validation of GEF-H1 Using a De Novo Designed Inhibitor in Models of Retinal Disease Open
Inflammation and fibrosis are important components of diseases that contribute to the malfunction of epithelia and endothelia. The Rho guanine nucleotide exchange factor (GEF) GEF-H1/ARHGEF-2 is induced in disease and stimulates inflammato…
View article: Design, synthesis, and evaluation of peptide‐imidazo[1,2‐<i>a</i>]pyrazine bioconjugates as potential bivalent inhibitors of the VirB11 ATPase HP0525
Design, synthesis, and evaluation of peptide‐imidazo[1,2‐<i>a</i>]pyrazine bioconjugates as potential bivalent inhibitors of the VirB11 ATPase HP0525 Open
Helicobacter pylori ( H. pylori ) infections have been implicated in the development of gastric ulcers and various cancers: however, the success of current therapies is compromised by rising antibiotic resistance. The virulence and pathoge…
View article: PDBe: improved findability of macromolecular structure data in the PDB
PDBe: improved findability of macromolecular structure data in the PDB Open
The Protein Data Bank in Europe (PDBe), a founding member of the Worldwide Protein Data Bank (wwPDB), actively participates in the deposition, curation, validation, archiving and dissemination of macromolecular structure data. PDBe support…
View article: Protein Data Bank: the single global archive for 3D macromolecular structure data
Protein Data Bank: the single global archive for 3D macromolecular structure data Open
The Protein Data Bank (PDB) is the single global archive of experimentally determined three-dimensional (3D) structure data of biological macromolecules. Since 2003, the PDB has been managed by the Worldwide Protein Data Bank (wwPDB; wwpdb…
View article: MOESM2 of HIV-1 capsid is involved in post-nuclear entry steps
MOESM2 of HIV-1 capsid is involved in post-nuclear entry steps Open
Additional file 2: Fig. S2. Diagrammatic representation of the CsA washout assay.