Paul J. Lucassen
YOU?
Author Swipe
View article: A novel approach to resilience and its links with education and Alzheimer's disease genetics
A novel approach to resilience and its links with education and Alzheimer's disease genetics Open
INTRODUCTION Cognitive resilience refers to maintaining cognitive function despite Alzheimer's disease (AD) pathophysiology. METHODS We analyzed amyloid‐positive individuals across clinical stages of AD in two cohorts: the Amsterdam Dement…
View article: Blood serum from individuals with Alzheimer’s disease alters microglial phagocytosis in vitro
Blood serum from individuals with Alzheimer’s disease alters microglial phagocytosis in vitro Open
In Alzheimer’s disease, microglial phagocytosis is engaged in the pathogenesis as it clears abnormal protein accumulations, debris, and apoptotic cells in the early stages of Alzheimer’s disease, but fuels neuroinflammation and accelerates…
View article: Cross‐Analysis of Single‐Cell Transcriptomic Datasets Reveals Conserved Neurogenic Gene Signatures and New Insights Into Neural Stem Cell Aging
Cross‐Analysis of Single‐Cell Transcriptomic Datasets Reveals Conserved Neurogenic Gene Signatures and New Insights Into Neural Stem Cell Aging Open
Hippocampal adult neural stem cells (NSCs) contribute to neurogenesis and astrogliogenesis throughout life. They play multifaceted roles in hippocampal function, including memory processing, stress regulation, and cognitive flexibility. Lo…
View article: Voluntary Running and Estrous Cycle Modulate ΔFOSB in the Suprachiasmatic Nucleus of the Wistar Rat
Voluntary Running and Estrous Cycle Modulate ΔFOSB in the Suprachiasmatic Nucleus of the Wistar Rat Open
The hypothalamic suprachiasmatic nucleus (SCN), the circadian pacemaker of the mammalian brain, integrates both environmental and endogenous information to modulate various physiological and behavioral processes. Both light and physical ac…
View article: Electroconvulsive therapy induces rapid microstructural and macrostructural changes, but microstructural changes are longer-lasting
Electroconvulsive therapy induces rapid microstructural and macrostructural changes, but microstructural changes are longer-lasting Open
Background Electroconvulsive therapy (ECT) is an effective treatment for major depressive episodes, though its mechanisms remain unclear. Its use is limited due to stigma and possible cognitive side-effects. Repeated magnetic resonance ima…
View article: Unique transcriptional profiles of adult human immature neurons in healthy aging, Alzheimer’s disease, and cognitive resilience
Unique transcriptional profiles of adult human immature neurons in healthy aging, Alzheimer’s disease, and cognitive resilience Open
The existence and functional significance of immature neurons in the adult human brain, particularly in the context of neurodegenerative disorders, remain controversial. While rodent studies have highlighted active roles for adult-born imm…
View article: How Can Early Stress Influence Later Alzheimer's Disease Risk? Possible Mediators and Underlying Mechanisms
How Can Early Stress Influence Later Alzheimer's Disease Risk? Possible Mediators and Underlying Mechanisms Open
View article: Traumatic brain injury promotes neurogenesis at the cost of astrogliogenesis in the adult hippocampus of male mice
Traumatic brain injury promotes neurogenesis at the cost of astrogliogenesis in the adult hippocampus of male mice Open
View article: Coffee polyphenols ameliorate early-life stress-induced cognitive deficits in male mice
Coffee polyphenols ameliorate early-life stress-induced cognitive deficits in male mice Open
View article: Association of dietary and nutritional factors with cognitive decline, dementia, and depressive symptomatology in older individuals according to a neurogenesis-centred biological susceptibility to brain ageing
Association of dietary and nutritional factors with cognitive decline, dementia, and depressive symptomatology in older individuals according to a neurogenesis-centred biological susceptibility to brain ageing Open
Hippocampal neurogenesis (HN) occurs throughout the life course and is important for memory and mood. Declining with age, HN plays a pivotal role in cognitive decline (CD), dementia, and late-life depression, such that altered HN could rep…
View article: Ageing, Cognitive Decline, and Effects of Physical Exercise: Complexities, and Considerations from Animal Models
Ageing, Cognitive Decline, and Effects of Physical Exercise: Complexities, and Considerations from Animal Models Open
In our ageing global population, the cognitive decline associated with dementia and neurodegenerative diseases represents a major healthcare problem. To date, there are no effective treatments for age-related cognitive impairment, thus pre…
View article: The 'middle-aging' brain
The 'middle-aging' brain Open
View article: Progesterone receptor distribution in the human hypothalamus and its association with suicide
Progesterone receptor distribution in the human hypothalamus and its association with suicide Open
View article: Which individual, social, and urban factors in early childhood predict psychopathology in later childhood, adolescence and young adulthood? A systematic review
Which individual, social, and urban factors in early childhood predict psychopathology in later childhood, adolescence and young adulthood? A systematic review Open
View article: Early‐life stress and amyloidosis in mice share pathogenic pathways involving synaptic mitochondria and lipid metabolism
Early‐life stress and amyloidosis in mice share pathogenic pathways involving synaptic mitochondria and lipid metabolism Open
INTRODUCTION Early‐life stress (ES) increases the risk for Alzheimer's disease (AD). We and others have shown that ES aggravates amyloid‐beta (Aβ) pathology and promotes cognitive dysfunction in APP/PS1 mice, but underlying mechanisms rema…
View article: Synergetic microRNA delivery for therapeutic targeting in Alzheimer’s disease
Synergetic microRNA delivery for therapeutic targeting in Alzheimer’s disease Open
Background Alzheimer’s disease (AD) is a complex multigenic disorder primarily defined by the presence of β‐amyloid‐containing plaques and Tau‐containing neurofibrillary tangles. To date, there is no available treatment and the failure of …
View article: Identifying Cognitive Resilience Related Genes Among Genetic Risk Loci of Alzheimer’s Disease
Identifying Cognitive Resilience Related Genes Among Genetic Risk Loci of Alzheimer’s Disease Open
Background Cognitive resilience (CR) in the context of Alzheimer’s disease (AD) describes the ability to maintain cognitive function despite the presence of neuropathology (Hohman et al., 2016). While most studies have focused on investiga…
View article: Electroconvulsive therapy is associated with increased immunoreactivity of neuroplasticity markers in the hippocampus of depressed patients
Electroconvulsive therapy is associated with increased immunoreactivity of neuroplasticity markers in the hippocampus of depressed patients Open
View article: Early Life Stress Enhances Cognitive Decline and Alters Synapse Function and Interneuron Numbers in Young Male APP/PS1 Mice
Early Life Stress Enhances Cognitive Decline and Alters Synapse Function and Interneuron Numbers in Young Male APP/PS1 Mice Open
Background: Exposure to stress early in life increases the susceptibility to Alzheimer’s disease (AD) pathology in aged AD mouse models. So far, the underlying mechanisms have remained elusive. Objective: To investigate 1) effects of early…
View article: A Mediterranean Diet‐Based Metabolomic Score and Cognitive Decline in Older Adults: A Case–Control Analysis Nested within the Three‐City Cohort Study
A Mediterranean Diet‐Based Metabolomic Score and Cognitive Decline in Older Adults: A Case–Control Analysis Nested within the Three‐City Cohort Study Open
Scope Evidence on the Mediterranean diet (MD) and age‐related cognitive decline (CD) is still inconclusive partly due to self‐reported dietary assessment. The aim of the current study is to develop an MD‐ metabolomic score (MDMS) and inves…
View article: Maternal stress is associated with higher protein-bound amino acid concentrations in human milk
Maternal stress is associated with higher protein-bound amino acid concentrations in human milk Open
Background Maternal stress in the postpartum period affects not only the mother but also her newborn child, who is at increased risk of developing metabolic and mental disorders later in life. The mechanisms by which stress is transmitted …
View article: Elevated corticosterone after fear learning impairs remote auditory memory retrieval and alters brain network connectivity
Elevated corticosterone after fear learning impairs remote auditory memory retrieval and alters brain network connectivity Open
Glucocorticoids are potent memory modulators that can modify behavior in an adaptive or maladaptive manner. Elevated glucocorticoid levels after learning promote memory consolidation at recent time points, but their effects on remote time …
View article: Electroconvulsive therapy is associated with increased immunoreactivity for the neuroplasticity marker doublecortin in the hippocampus of depressed patients
Electroconvulsive therapy is associated with increased immunoreactivity for the neuroplasticity marker doublecortin in the hippocampus of depressed patients Open
Electroconvulsive therapy (ECT) is an effective therapy for depression, but its cellular effects on the human brain remain elusive. In rodents, electroconvulsive shocks increase proliferation and the expression of plasticity markers in the…
View article: Early-life stress exposure impacts the hippocampal synaptic proteome in a mouse model of Alzheimer’s disease: age- and pathology-dependent effects on mitochondrial proteins
Early-life stress exposure impacts the hippocampal synaptic proteome in a mouse model of Alzheimer’s disease: age- and pathology-dependent effects on mitochondrial proteins Open
Epidemiological evidence indicates that early life stress (ES) exposure increases the risk for later-life diseases, such as Alzheimer’s disease (AD). Accordingly, we and others have shown that ES aggravates the development of, and response…
View article: Mapping human adult hippocampal neurogenesis with single-cell transcriptomics: Reconciling controversy or fueling the debate?
Mapping human adult hippocampal neurogenesis with single-cell transcriptomics: Reconciling controversy or fueling the debate? Open
View article: Adult hippocampal neurogenesis in Alzheimer’s disease: A roadmap to clinical relevance
Adult hippocampal neurogenesis in Alzheimer’s disease: A roadmap to clinical relevance Open
View article: Early-life stress and early diet modulate the risk for Alzheimer’s disease: focus on microglia and polyunsaturated fatty acids in APP/PS1 mice
Early-life stress and early diet modulate the risk for Alzheimer’s disease: focus on microglia and polyunsaturated fatty acids in APP/PS1 mice Open
View article: Interactions between daily physical activity and depressive and anxiety-related symptoms in adolescents remitted from depression and anxiety disorders
Interactions between daily physical activity and depressive and anxiety-related symptoms in adolescents remitted from depression and anxiety disorders Open
View article: Stress-associated purinergic receptors code for fatal suicidality in the hippocampal-hypothalamic-prefrontal circuit
Stress-associated purinergic receptors code for fatal suicidality in the hippocampal-hypothalamic-prefrontal circuit Open
Imbalanced purine metabolism is a key neurological basis for suicide and mood disorders (MD), wherein purinergic receptors in stress-sensitive cerebral regions are thought to be differentially activated. A hippocampal network that links th…
View article: Exploration of the Gut–Brain Axis through Metabolomics Identifies Serum Propionic Acid Associated with Higher Cognitive Decline in Older Persons
Exploration of the Gut–Brain Axis through Metabolomics Identifies Serum Propionic Acid Associated with Higher Cognitive Decline in Older Persons Open
The gut microbiome is involved in nutrient metabolism and produces metabolites that, via the gut–brain axis, signal to the brain and influence cognition. Human studies have so far had limited success in identifying early metabolic alterati…