Paul Hamilton
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View article: Commentary on Unusual Hypercholesterolemia in an Infant with Biliary Atresia
Commentary on Unusual Hypercholesterolemia in an Infant with Biliary Atresia Open
View article: Improving Familial Hypercholesterolemia Detection Through Implementation of Nurse-led Cascade Screening
Improving Familial Hypercholesterolemia Detection Through Implementation of Nurse-led Cascade Screening Open
Aims/Background Familial hypercholesterolemia (FH) is a genetic disorder that leads to premature cardiovascular disease. Early detection and treatment are crucial for reducing morbidity and mortality. This study describes the development a…
View article: Community Conversations as a Strategy to Prevent Hate Crime: Facilitators’ Reflections
Community Conversations as a Strategy to Prevent Hate Crime: Facilitators’ Reflections Open
Hate crimes damage social cohesion and undermine the security of societies. Persistent high levels of hate crime demand new and effective pathways for change. The aim of this article is to consider the value of ‘community conversations’ fo…
View article: Rare variant genetic landscape of familial chylomicronemia syndrome (FCS) in the United Kingdom
Rare variant genetic landscape of familial chylomicronemia syndrome (FCS) in the United Kingdom Open
The genetic architecture of FCS in the United Kingdom is complex, with a substantial proportion affected by non-LPL FCS-causing genes. It also displays a significant regional and ethnic variations.
View article: “Inspiration’s darling child”: The Romantic Ode
“Inspiration’s darling child”: The Romantic Ode Open
View article: The effects of controlled acute psychological stress on serum cortisol and plasma metanephrine concentrations in healthy subjects
The effects of controlled acute psychological stress on serum cortisol and plasma metanephrine concentrations in healthy subjects Open
Background As cortisol and metanephrine are involved in the stress response, it is often recommended that individuals are relaxed at the time of venepuncture, however, evidence behind these recommendations is lacking. We investigated the e…
View article: Simulate to stimulate? A systematic review of stress, learning, and performance in healthcare simulation.
Simulate to stimulate? A systematic review of stress, learning, and performance in healthcare simulation. Open
In recent years, simulation has come to prominence as an educational method within the healthcare professions, aiming to shield learners from real-world consequences. However, the associated risks of this educational method have largely re…
View article: Ethnic Diversity and Distinctive Features of Familial Versus Multifactorial Chylomicronemia Syndrome: Insights From the UK FCS National Registry
Ethnic Diversity and Distinctive Features of Familial Versus Multifactorial Chylomicronemia Syndrome: Insights From the UK FCS National Registry Open
BACKGROUND: Familial chylomicronemia syndrome (FCS) is a rare autosomal recessive disorder. This study aimed to study the genotype distribution of FCS-causing genes in the United Kingdom, genotype-phenotype correlation, and clinical differ…
View article: Correction to: Safety and Immunogenicity of a Recombinant Two-Component SARS-CoV-2 Protein Vaccine: Randomized, Double-Blind, Placebo-Controlled Phase I and Phase II Studies
Correction to: Safety and Immunogenicity of a Recombinant Two-Component SARS-CoV-2 Protein Vaccine: Randomized, Double-Blind, Placebo-Controlled Phase I and Phase II Studies Open
View article: Hallux Flexion Deformity Secondary to Fibula Harvesting in a 10-Year-Old Patient With Neurofibromatosis
Hallux Flexion Deformity Secondary to Fibula Harvesting in a 10-Year-Old Patient With Neurofibromatosis Open
View article: Commentary on Understanding Elevated Vitamin D Measurements to Uncover Hypercalcemia Etiology
Commentary on Understanding Elevated Vitamin D Measurements to Uncover Hypercalcemia Etiology Open
probable cross-reactivity with 1,24,25(OH) 3 D (this information is not displayed in the manufacturer's instructions for use).This report confirms the superiority of LC-MS/MS over immunoassays for the measurement of vitamin D metabolites a…
View article: Validation of the familial chylomicronaemia syndrome (FCS) score in an ethnically diverse cohort from UK FCS registry: Implications for diagnosis and differentiation from multifactorial chylomicronaemia syndrome (MCS)
Validation of the familial chylomicronaemia syndrome (FCS) score in an ethnically diverse cohort from UK FCS registry: Implications for diagnosis and differentiation from multifactorial chylomicronaemia syndrome (MCS) Open
View article: Untapped resource: the simulation-based healthcare environment as a means to study human stress.
Untapped resource: the simulation-based healthcare environment as a means to study human stress. Open
The effects of 'stress' within the healthcare professions are wide-reaching, not least of all within the field of simulation-based healthcare education. Whilst this popular method of experiential learning offers a 'safe space' for particip…
View article: Safety and Immunogenicity of a Recombinant Two-Component SARS-CoV-2 Protein Vaccine: Randomized, Double-Blind, Placebo-Controlled Phase I and Phase II Studies
Safety and Immunogenicity of a Recombinant Two-Component SARS-CoV-2 Protein Vaccine: Randomized, Double-Blind, Placebo-Controlled Phase I and Phase II Studies Open
View article: The caveats of wearable stress monitoring technology – in response to MacQuarrie et al., 2023
The caveats of wearable stress monitoring technology – in response to MacQuarrie et al., 2023 Open
View article: Safety and Immunogenicity of the BNT162b2 Vaccine Coadministered with Seasonal Inactivated Influenza Vaccine in Adults
Safety and Immunogenicity of the BNT162b2 Vaccine Coadministered with Seasonal Inactivated Influenza Vaccine in Adults Open
ClinicalTrials.gov registration: NCT05310084.
View article: The evaluation of stress during medical simulation: a feasibility study involving final-year medical students
The evaluation of stress during medical simulation: a feasibility study involving final-year medical students Open
Student stress is well-documented within the field of simulation-based medical education. However, current research is unclear as to what level of stress is optimal for an enhanced educational experience. This ambiguity may partly be due t…
View article: Guide to developing effective content for Highly Immersive Virtual Environments
Guide to developing effective content for Highly Immersive Virtual Environments Open
View article: Long-term effects of volanesorsen on triglycerides and pancreatitis in patients with familial chylomicronaemia syndrome (FCS) in the UK Early Access to Medicines Scheme (EAMS)
Long-term effects of volanesorsen on triglycerides and pancreatitis in patients with familial chylomicronaemia syndrome (FCS) in the UK Early Access to Medicines Scheme (EAMS) Open
View article: A randomized, double-blind, 3-arm, parallel study assessing the pharmacokinetics, safety, tolerability and immunogenicity of AVT04, an ustekinumab candidate biosimilar, in healthy adults
A randomized, double-blind, 3-arm, parallel study assessing the pharmacokinetics, safety, tolerability and immunogenicity of AVT04, an ustekinumab candidate biosimilar, in healthy adults Open
Results supported a demonstration of PK similarity between candidate biosimilar AVT04, US-RP and EU-RP. Similar safety and immunogenicity were also shown.Clinical trial registration: www.clinicaltrials.gov identifier is NCT04744363.
View article: Severe Hypertriglyceridaemia and Chylomicronaemia Syndrome—Causes, Clinical Presentation, and Therapeutic Options
Severe Hypertriglyceridaemia and Chylomicronaemia Syndrome—Causes, Clinical Presentation, and Therapeutic Options Open
We have reviewed the genetic basis of chylomicronaemia, the difference between monogenic and polygenic hypertriglyceridaemia, its effects on pancreatic, cardiovascular, and microvascular complications, and current and potential future phar…
View article: Are foot and ankle corticosteroid injections safe during the COVID-19 pandemic? A single center prospective observational study
Are foot and ankle corticosteroid injections safe during the COVID-19 pandemic? A single center prospective observational study Open
View article: Biological testing during acute psychological stress: A hindrance or an opportunity?
Biological testing during acute psychological stress: A hindrance or an opportunity? Open
All humans deal with acute psychological stress periodically. Some individuals are affected by needle phobia in which a heightened sense of arousal is precipitated by venepuncture. Acute psychological stress invokes a range of physiologica…
View article: Spoonful of sugar: a case for stress-reduction interventions in medical simulation
Spoonful of sugar: a case for stress-reduction interventions in medical simulation Open
In recent years simulation has gained popularity as an educational tool to shield learners from real-world consequence. However, the inherent risks levied upon those involved have largely remained unaddressed; psychological stress being on…
View article: Real world efficacy of bempedoic acid in statin-intolerant patients with high cardiovascular risk
Real world efficacy of bempedoic acid in statin-intolerant patients with high cardiovascular risk Open
View article: Love and Death in St Pancras Churchyard
Love and Death in St Pancras Churchyard Open
View article: The preliminary safety and immunogenicity results of a randomized, double-blind, placebo-controlled Phase I trial for a recombinant two-component subunit SARS-CoV-2 vaccine ReCOV
The preliminary safety and immunogenicity results of a randomized, double-blind, placebo-controlled Phase I trial for a recombinant two-component subunit SARS-CoV-2 vaccine ReCOV Open
Summary Background The ReCOV is a recombinant trimeric two-component SARS-CoV-2 subunit vaccine adjuvanted with BFA03. We report the preliminary safety and immunogenicity results for the ReCOV. Methods This first in human, randomized, doub…
View article: USO DE LATERAL CRURAL STRUT GRAFTS ASSOCIADO À ROTAÇÃO CAUDAL DAS CARTILAGENS LATERAIS INFERIORES NO TRATAMENTO DA DISFUNÇÃO DE VÁLVULA NASAL EXTERNA: RELATO DE CASO
USO DE LATERAL CRURAL STRUT GRAFTS ASSOCIADO À ROTAÇÃO CAUDAL DAS CARTILAGENS LATERAIS INFERIORES NO TRATAMENTO DA DISFUNÇÃO DE VÁLVULA NASAL EXTERNA: RELATO DE CASO Open
Introduction: Nasal valve concept includes internal and external valve (ENV). Conditions that alter the structure of the ENV precipitate its dysfunction. Objective: Report a case of ENV dysfunction treated with repositioning of lower later…
View article: Case Based Learning Facilitator.
Case Based Learning Facilitator. Open
View article: So you want to be a Case Based Learning Facilitator
So you want to be a Case Based Learning Facilitator Open