Paul Kubelac
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View article: Neutrophil to Lymphocyte Ratio a Prognostic Tool in Endometrial Cancer Among Classical Prognostic Factors
Neutrophil to Lymphocyte Ratio a Prognostic Tool in Endometrial Cancer Among Classical Prognostic Factors Open
Background: Endometrial cancer (EC) is the most common gynecologic malignancy in developed countries. Despite advances in diagnosis and treatment, recurrence and mortality remain significant concerns. The neutrophil-to-lymphocyte ratio (NL…
View article: The Genomic Landscape of Romanian Non-Small Cell Lung Cancer Patients: The Insights from Routine NGS Testing with the Oncomine™ Dx Express Test at the PATHOS Molecular Pathology Laboratory
The Genomic Landscape of Romanian Non-Small Cell Lung Cancer Patients: The Insights from Routine NGS Testing with the Oncomine™ Dx Express Test at the PATHOS Molecular Pathology Laboratory Open
Background: Comprehensive molecular profiling is essential for precision oncology in non-small cell lung cancer (NSCLC). However, genomic data from Eastern European populations, including Romania, remain limited. Methods: We analyzed 398 c…
View article: Prospective Upfront Next-Generation Sequencing for Advanced Non-Small Cell Lung Cancer: Real-World Outcomes from the Ion Chiricuță Oncology Institute
Prospective Upfront Next-Generation Sequencing for Advanced Non-Small Cell Lung Cancer: Real-World Outcomes from the Ion Chiricuță Oncology Institute Open
Upfront Next-Generation Sequencing (NGS) is increasingly recommended in advanced NSCLC to guide targeted therapy. This prospective single-center study in Romania evaluated routine, upfront NGS in advanced NSCLC at baseline (tissue and/or l…
View article: Intraoperative imaging of residual ovarian cancer after neoadjuvant chemotherapy using indocyanine green
Intraoperative imaging of residual ovarian cancer after neoadjuvant chemotherapy using indocyanine green Open
The use of ICG was associated with an increase in the resection of samples with residual malignant foci. Overall, hypointense areas had a higher positive PPV for malignant foci in comparison with hyperintense ICG areas (46% vs 30%), which …
View article: Efficacy of chemotherapy after progression during or following PARPi exposure in ovarian cancer
Efficacy of chemotherapy after progression during or following PARPi exposure in ovarian cancer Open
This is the largest real-world study assessing the efficacy of subsequent chemotherapy in patients progressing during PARPi exposure. The patients have poor outcomes. PBC is the best option in patients progressing on PARPi and eligible for…
View article: Use of Different Anti-PD-1 Checkpoint Combination Strategies for First-Line Advanced NSCLC Treatment—The Experience of Ion Chiricuță Oncology Institute
Use of Different Anti-PD-1 Checkpoint Combination Strategies for First-Line Advanced NSCLC Treatment—The Experience of Ion Chiricuță Oncology Institute Open
Purpose. Different combination modalities between an anti-PD-1/PD-L1 agent and a platinum-based chemotherapy or another checkpoint inhibitor (with or without a short course or full course of a platinum doublet) proved superior to chemother…
View article: Usefulness of Saline Sealing in Preventing Pneumothorax after CT-Guided Biopsies of the Lung
Usefulness of Saline Sealing in Preventing Pneumothorax after CT-Guided Biopsies of the Lung Open
This study aimed to assess the effectiveness of saline sealing in reducing the incidence of pneumothorax after a CT-guided lung biopsy. This was a retrospective case-control study of patients who underwent CT-guided biopsies for lung tumor…
View article: #103 Epigenetic silencing of MLH1 as a prognostic factor for endometrial cancer recurrence
#103 Epigenetic silencing of MLH1 as a prognostic factor for endometrial cancer recurrence Open
Introduction/Background Aberrant DNA methylation is a common phenomenon in different types of cancer, but its patterns, causes, and consequences are poorly defined. Promoter hypermethylation of the DNA mismatch repair (MLH1) has been impli…
View article: #746 Molecular analysis of BRCA and hrd status from small biopsies in high grade serous carcinoma. a real-world comparative analysis
#746 Molecular analysis of BRCA and hrd status from small biopsies in high grade serous carcinoma. a real-world comparative analysis Open
Introduction/Background Treatment in high-grade serous ovarian cancer (HGSOC) depends upon knowledge of BRCA and homologous recombination deficiency (HRD) status. Hence, tumor quality is critical for successful genomic analyses. We investi…
View article: #1004 Impact of hormone replacement therapy on the overall survival and progression free survival of ovarian cancer patients: a systematic review and meta-analysis
#1004 Impact of hormone replacement therapy on the overall survival and progression free survival of ovarian cancer patients: a systematic review and meta-analysis Open
Introduction/Background The standard treatment course for ovarian cancer virtually always induces menopause with subsequent symptoms. Even though climax morbidity has been intensely investigated over the past decades, HRT remains a content…
View article: #201 Real world evidence (RWE) on the efficacy of chemotherapy after progression during or following PARPi exposure in ovarian cancer. a multicentre, international study
#201 Real world evidence (RWE) on the efficacy of chemotherapy after progression during or following PARPi exposure in ovarian cancer. a multicentre, international study Open
Introduction/Background A significant proportion of OC patients eventually progress during or following PARPi exposure. Progression under PARPi may undermine sensitivity to chemotherapy. Methodology We retrospectively identified patients t…
View article: Ovarian Real-World International Consortium (ORWIC): A multicentre, real-world analysis of epithelial ovarian cancer treatment and outcomes
Ovarian Real-World International Consortium (ORWIC): A multicentre, real-world analysis of epithelial ovarian cancer treatment and outcomes Open
Introduction Much drug development and published analysis for epithelial ovarian cancer (EOC) focuses on early-line treatment. Full sequences of treatment from diagnosis to death and the impact of later lines of therapy are rarely studied.…
View article: 2022-RA-1405-ESGO Indocyanine green in near-infrared light for intra-operative imaging of residual ovarian cancer after neoadjuvant chemotherapy. Initial experience
2022-RA-1405-ESGO Indocyanine green in near-infrared light for intra-operative imaging of residual ovarian cancer after neoadjuvant chemotherapy. Initial experience Open
View article: 2022-RA-437-ESGO Meta-analyses reveal serum or plasma interleukin-6 as a biomarker for malignant ovarian neoplasia
2022-RA-437-ESGO Meta-analyses reveal serum or plasma interleukin-6 as a biomarker for malignant ovarian neoplasia Open
View article: Antiproliferative Ruthenium Complexes Containing Curcuminoid Ligands Tested In Vitro on Human Ovarian Tumor Cell Line A2780, towards Their Capability to Modulate the NF-κBTranscription Factor, FGF-2 Growth Factor, and MMP-9 Pathway
Antiproliferative Ruthenium Complexes Containing Curcuminoid Ligands Tested In Vitro on Human Ovarian Tumor Cell Line A2780, towards Their Capability to Modulate the NF-κBTranscription Factor, FGF-2 Growth Factor, and MMP-9 Pathway Open
So far, the polyphenolic components of turmeric have shown a significant pharmacological preventative activity for a wide spectrum of diseases, including oncological disorders. This type of natural product could be of great interest for th…
View article: Evolutionary perspectives, heterogeneity and ovarian cancer: a complicated tale from past to present
Evolutionary perspectives, heterogeneity and ovarian cancer: a complicated tale from past to present Open
View article: Outcomes of patients with cancer infected with SARS-CoV-2: results from the Ion Chiricuţă Oncology Institute series
Outcomes of patients with cancer infected with SARS-CoV-2: results from the Ion Chiricuţă Oncology Institute series Open
View article: Status of the Sentinel Lymph Node in Patients with Endometrial Cancer Stage I-II
Status of the Sentinel Lymph Node in Patients with Endometrial Cancer Stage I-II Open
Endometrial cancer (EC) is the most common gynecological cancer in developed countries. In literature, there are discordant data regarding the therapeutic value of systematic lymphadenectomy whereas the importance of lymph node status for …
View article: Adenosquamous Carcinoma of the Uterine Cervix – Impact of Histology on Clinical Management
Adenosquamous Carcinoma of the Uterine Cervix – Impact of Histology on Clinical Management Open
The histological subtype of cancer of the uterine cervix has an impact on prognosis and should not be simply considered as a descriptive characteristic but a poor prognostic feature and should be an integral part of the decision-making in …
View article: Does Surgical Margin Width Remain a Challenge for Triple-Negative Breast Cancer? A Retrospective Analysis
Does Surgical Margin Width Remain a Challenge for Triple-Negative Breast Cancer? A Retrospective Analysis Open
Background and Objectives: Local and distant relapse (LR, DR) in breast cancer vary according to its molecular subtypes, with triple-negative breast cancer (TNBC) being the most aggressive. The surgical resection margin width (SRMW) for br…
View article: Comprehensive Analysis of the Expression of Key Genes Related to Hippo Signaling and Their Prognosis Impact in Ovarian Cancer
Comprehensive Analysis of the Expression of Key Genes Related to Hippo Signaling and Their Prognosis Impact in Ovarian Cancer Open
The Hippo signaling pathway, one of the most conserved in humans, controlling dimensions of organs and tumor growth, is frequently deregulated in several human malignancies, including ovarian cancer (OC). The alteration of Hippo signaling …
View article: The shifting landscape of genetic alterations separating endometriosis and ovarian endometrioid carcinoma.
The shifting landscape of genetic alterations separating endometriosis and ovarian endometrioid carcinoma. Open
Ovarian cancer is one of the most common cancers worldwide, and is associated with a prior diagnosis of endometriosis in several cases. Our aim was to correlate genetic and methylation profile of ovarian endometrioid ovarian cancer and end…
View article: Changes in DNA Damage Response Markers with Treatment in Advanced Ovarian Cancer
Changes in DNA Damage Response Markers with Treatment in Advanced Ovarian Cancer Open
Ovarian cancer (OC) is sensitive to upfront chemotherapy, which is likely attributable to defects in DNA damage repair (DDR). Unfortunately, patients relapse and the evolution of DDR competency are poorly described. We examined the express…
View article: <p>SERS-based differential diagnosis between multiple solid malignancies: breast, colorectal, lung, ovarian and oral cancer</p>
SERS-based differential diagnosis between multiple solid malignancies: breast, colorectal, lung, ovarian and oral cancer Open
SERS on serum represents a promising strategy of diagnosing cancer which can discriminate between cancer patients and controls, as well as between cancer types such as breast, colorectal, lung ovarian and oral cancer.
View article: SERS-based differential diagnosis between multiple solid malignancies: breast, colorectal, lung, ovarian and oral cancer
SERS-based differential diagnosis between multiple solid malignancies: breast, colorectal, lung, ovarian and oral cancer Open
Vlad Moisoiu,1,2,* Andrei Stefancu,1,3,* Diana Gulei,3,* Radu Boitor,4 Lorand Magdo,2,5 Lajos Raduly,5,6 Sergiu Pasca,2 Paul Kubelac,2,7 Nikolay Mehterov,8,9 Vasile Chiș,1 Marioara Simon,10 Mihai Muresan,2,11–12 Alexandra Iulia Irimie,13 M…