Paul Kubes
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View article: P selectin promotes SARS-CoV-2 interactions with platelets and the endothelium
P selectin promotes SARS-CoV-2 interactions with platelets and the endothelium Open
The physiology of SARS-CoV-2 virus/host interactions is not well understood. To better understand host/virus interactions, we performed a CRISPR activation screen to identify host genes that confer resistance to authentic SARS-CoV-2. This …
View article: PIEZO1 mediates mechanical reprogramming of neutrophils for proangiogenic specialization in the lung
PIEZO1 mediates mechanical reprogramming of neutrophils for proangiogenic specialization in the lung Open
Neutrophils are the most abundant immune cells that constantly patrol or marginate inside vascular beds to support immune homeostasis. The extent to which neutrophils undergo reprogramming in response to the changes in vascular architectur…
View article: Imaging a concussion and the ensuing immune response at the blood–brain barrier
Imaging a concussion and the ensuing immune response at the blood–brain barrier Open
Concussions can cause debilitating symptoms despite no evidence of structural changes on diagnostic imaging. The cellular events occurring in the brain parenchyma following concussion, especially repetitive concussion, are not well elucida…
View article: Plasma Fibronectin Released by Peritoneal Macrophages Promotes Remote Skin Wound Healing
Plasma Fibronectin Released by Peritoneal Macrophages Promotes Remote Skin Wound Healing Open
Background Large peritoneal macrophages (LPMs), located in the peritoneal cavity, are essential for local tissue repair. However, their contribution to tissue repair at distant sites remains unclear. Aims This study investigates the role o…
View article: B cell-derived acetylcholine promotes liver regeneration by regulating Kupffer cell and hepatic CD8+ T cell function
B cell-derived acetylcholine promotes liver regeneration by regulating Kupffer cell and hepatic CD8+ T cell function Open
Liver regeneration (LR) is essential for recovery from acute trauma, cancer surgery, or transplantation. Neurotransmitters such as acetylcholine (ACh) play a role in LR by stimulating immune cells and augmenting hepatocyte proliferation, b…
View article: Innate immunity of the lungs in homeostasis and disease
Innate immunity of the lungs in homeostasis and disease Open
Humans breathe thousands of litres of non-sterile air each day containing bacteria, viruses, and fungi, as well as pollutants, allergens, and other particles. The continual exposure to foreign particles is juxtaposed with the vast surface …
View article: Mitochondrial transplantation: A novel therapy for liver ischemia/reperfusion injury
Mitochondrial transplantation: A novel therapy for liver ischemia/reperfusion injury Open
MINI-ABSTRACT Mitochondrial transplantation prevented liver ischemia/reperfusion-induced hepatocellular injury and inflammation. In vivo intravital microscopy demonstrated that liver resident macrophages, namely Kupffer cells, rapidly sequ…
View article: Intravital imaging of three different microvascular beds in SARS-CoV-2–infected mice
Intravital imaging of three different microvascular beds in SARS-CoV-2–infected mice Open
Severe acute respiratory syndrome coronavirus–2 (SARS-CoV-2) enters the respiratory tract, where it infects the alveoli epithelial lining. However, patients have sequelae that extend well beyond the alveoli into the pulmonary vasculature a…
View article: Supplementary Video 3 from Imaging α-GalCer–Activated iNKT Cells in a Hepatic Metastatic Environment
Supplementary Video 3 from Imaging α-GalCer–Activated iNKT Cells in a Hepatic Metastatic Environment Open
Supplementary Video 3
View article: Supplementary Video 1 from Imaging α-GalCer–Activated iNKT Cells in a Hepatic Metastatic Environment
Supplementary Video 1 from Imaging α-GalCer–Activated iNKT Cells in a Hepatic Metastatic Environment Open
Supplementary Video 1
View article: Supplementary Video 2 from Imaging α-GalCer–Activated iNKT Cells in a Hepatic Metastatic Environment
Supplementary Video 2 from Imaging α-GalCer–Activated iNKT Cells in a Hepatic Metastatic Environment Open
Supplementary Video 2
View article: Data from Imaging α-GalCer–Activated iNKT Cells in a Hepatic Metastatic Environment
Data from Imaging α-GalCer–Activated iNKT Cells in a Hepatic Metastatic Environment Open
Patients with colorectal cancer frequently develop liver metastases after, and perhaps as a consequence of, lifesaving surgical resection of the primary tumor. This creates a potential opportunity for prophylactic metastatic treatment with…
View article: Supplementary video 4 from Imaging α-GalCer–Activated iNKT Cells in a Hepatic Metastatic Environment
Supplementary video 4 from Imaging α-GalCer–Activated iNKT Cells in a Hepatic Metastatic Environment Open
Supplementary Video 4
View article: Supplementary video 4 from Imaging α-GalCer–Activated iNKT Cells in a Hepatic Metastatic Environment
Supplementary video 4 from Imaging α-GalCer–Activated iNKT Cells in a Hepatic Metastatic Environment Open
Supplementary Video 4
View article: Supplementary Figures and Video Legends from Imaging α-GalCer–Activated iNKT Cells in a Hepatic Metastatic Environment
Supplementary Figures and Video Legends from Imaging α-GalCer–Activated iNKT Cells in a Hepatic Metastatic Environment Open
Supplementary Figures 1-8 Plus Supplementary Video Legends
View article: Supplementary Video 2 from Imaging α-GalCer–Activated iNKT Cells in a Hepatic Metastatic Environment
Supplementary Video 2 from Imaging α-GalCer–Activated iNKT Cells in a Hepatic Metastatic Environment Open
Supplementary Video 2
View article: Supplementary Video 1 from Imaging α-GalCer–Activated iNKT Cells in a Hepatic Metastatic Environment
Supplementary Video 1 from Imaging α-GalCer–Activated iNKT Cells in a Hepatic Metastatic Environment Open
Supplementary Video 1
View article: Supplementary Figures and Video Legends from Imaging α-GalCer–Activated iNKT Cells in a Hepatic Metastatic Environment
Supplementary Figures and Video Legends from Imaging α-GalCer–Activated iNKT Cells in a Hepatic Metastatic Environment Open
Supplementary Figures 1-8 Plus Supplementary Video Legends
View article: Supplementary Video 3 from Imaging α-GalCer–Activated iNKT Cells in a Hepatic Metastatic Environment
Supplementary Video 3 from Imaging α-GalCer–Activated iNKT Cells in a Hepatic Metastatic Environment Open
Supplementary Video 3
View article: Data from Imaging α-GalCer–Activated iNKT Cells in a Hepatic Metastatic Environment
Data from Imaging α-GalCer–Activated iNKT Cells in a Hepatic Metastatic Environment Open
Patients with colorectal cancer frequently develop liver metastases after, and perhaps as a consequence of, lifesaving surgical resection of the primary tumor. This creates a potential opportunity for prophylactic metastatic treatment with…
View article: Supplementary Figure 4 from Preventing the Activation or Cycling of the Rap1 GTPase Alters Adhesion and Cytoskeletal Dynamics and Blocks Metastatic Melanoma Cell Extravasation into the Lungs
Supplementary Figure 4 from Preventing the Activation or Cycling of the Rap1 GTPase Alters Adhesion and Cytoskeletal Dynamics and Blocks Metastatic Melanoma Cell Extravasation into the Lungs Open
Supplementary Figure 4 from Preventing the Activation or Cycling of the Rap1 GTPase Alters Adhesion and Cytoskeletal Dynamics and Blocks Metastatic Melanoma Cell Extravasation into the Lungs
View article: Supplementary Figure 2 from Neutrophils Promote Liver Metastasis via Mac-1–Mediated Interactions with Circulating Tumor Cells
Supplementary Figure 2 from Neutrophils Promote Liver Metastasis via Mac-1–Mediated Interactions with Circulating Tumor Cells Open
PDF file - 61K, FACS analysis of ICAM-1 presence on H-59 murine lung cancer cells
View article: Supplementary Figure Legends 1-6 from Preventing the Activation or Cycling of the Rap1 GTPase Alters Adhesion and Cytoskeletal Dynamics and Blocks Metastatic Melanoma Cell Extravasation into the Lungs
Supplementary Figure Legends 1-6 from Preventing the Activation or Cycling of the Rap1 GTPase Alters Adhesion and Cytoskeletal Dynamics and Blocks Metastatic Melanoma Cell Extravasation into the Lungs Open
Supplementary Figure Legends 1-6 from Preventing the Activation or Cycling of the Rap1 GTPase Alters Adhesion and Cytoskeletal Dynamics and Blocks Metastatic Melanoma Cell Extravasation into the Lungs