Paul Leeson
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View article: Contemporary review of stress echocardiography workforce within the UK: an EVAREST/BSE NSTEP study
Contemporary review of stress echocardiography workforce within the UK: an EVAREST/BSE NSTEP study Open
View article: Development and Validation of Echocardiography Artificial Intelligence Models: A Narrative Review
Development and Validation of Echocardiography Artificial Intelligence Models: A Narrative Review Open
Echocardiography is a first-line, non-invasive imaging modality widely used to assess cardiac structure and function; however, its interpretation remains highly operator dependent and subject to variability. The integration of artificial i…
View article: Cardiovascular disease in women: do we focus on single jigsaw pieces or look at the whole puzzle?
Cardiovascular disease in women: do we focus on single jigsaw pieces or look at the whole puzzle? Open
View article: Impact of Blood Pressure Self-Management on Vascular Remodeling After Hypertensive Pregnancy
Impact of Blood Pressure Self-Management on Vascular Remodeling After Hypertensive Pregnancy Open
BACKGROUND: Hypertensive pregnancy disorders are associated with long-term adverse cardiac and vascular remodeling post index pregnancy. The POP-HT trial (Physician Optimised Postpartum Hypertension Treatment) demonstrated that improved pu…
View article: Subclinical Postpartum Renal Structure After Hypertensive Pregnancy Disorders
Subclinical Postpartum Renal Structure After Hypertensive Pregnancy Disorders Open
BACKGROUND: Hypertensive pregnancies are associated with increased risks of renal failure in pregnancy and later life. However, traditional markers of renal function normalize postpartum, making identification of those at future disease ri…
View article: Clinical research and trials in echocardiography: rationale, requirements and future opportunities
Clinical research and trials in echocardiography: rationale, requirements and future opportunities Open
View article: International guidelines for the management of hypertensive disorders of pregnancy: an opportunity to improve the lifelong health of women?
International guidelines for the management of hypertensive disorders of pregnancy: an opportunity to improve the lifelong health of women? Open
View article: Exercise Improves Myocardial Deformation But Not Cardiac Structure in Preterm-Born Adults
Exercise Improves Myocardial Deformation But Not Cardiac Structure in Preterm-Born Adults Open
View article: Author Correction: External validation of artificial intelligence for detection of heart failure with preserved ejection fraction
Author Correction: External validation of artificial intelligence for detection of heart failure with preserved ejection fraction Open
View article: External validation of artificial intelligence for detection of heart failure with preserved ejection fraction
External validation of artificial intelligence for detection of heart failure with preserved ejection fraction Open
Artificial intelligence (AI) models to identify heart failure (HF) with preserved ejection fraction (HFpEF) based on deep-learning of echocardiograms could help address under-recognition in clinical practice, but they require extensive val…
View article: Changes in coronary disease management decisions in real-world practice between 2015 and 2023: insights from the EVAREST/BSE-NSTEP observational study
Changes in coronary disease management decisions in real-world practice between 2015 and 2023: insights from the EVAREST/BSE-NSTEP observational study Open
Aims To assess the real-world impact of updated clinical guidelines and literature on the management of patients undergoing stress echocardiography for the assessment of inducible ischaemia across a national health service. Methods and res…
View article: Correction: Distinct circle of willis anatomical configurations in healthy preterm born adults: a 3D time-of-flight magnetic resonance angiography study
Correction: Distinct circle of willis anatomical configurations in healthy preterm born adults: a 3D time-of-flight magnetic resonance angiography study Open
View article: Distinct Circle of Willis anatomical configurations in healthy preterm born adults: a 3D time-of-flight magnetic resonance angiography study
Distinct Circle of Willis anatomical configurations in healthy preterm born adults: a 3D time-of-flight magnetic resonance angiography study Open
Background Preterm birth (< 37 weeks’ gestation) alters cerebrovascular development due to the premature transition from a foetal to postnatal circulatory system, with potential implications for future cerebrovascular health. This study ai…
View article: Self-monitoring blood pressure in pregnancy: evaluation of women’s experiences of the BUMP trials
Self-monitoring blood pressure in pregnancy: evaluation of women’s experiences of the BUMP trials Open
View article: Long-term outcomes after stress echocardiography in real-world practice: a 5-year follow-up of the UK EVAREST study
Long-term outcomes after stress echocardiography in real-world practice: a 5-year follow-up of the UK EVAREST study Open
Aims Stress echocardiography is widely used to assess patients with chest pain. The clinical value of a positive or negative test result to inform on likely longer-term outcomes when applied in real-world practice across a healthcare syste…
View article: Author response to discussion forum—EVAREST trial by Max Berrill
Author response to discussion forum—EVAREST trial by Max Berrill Open
View article: Improvement in myocardial deformation but not structural indices in adults born preterm following a prescribed aerobic exercise intervention: a randomized clinical trial
Improvement in myocardial deformation but not structural indices in adults born preterm following a prescribed aerobic exercise intervention: a randomized clinical trial Open
Background People born preterm (<37 weeks’ gestation) have a potentially adverse cardiac phenotype that progresses with blood pressure elevation. We sought to determine whether preterm-born adults with elevated and stage 1 hypertension exh…
View article: Multi‐Organ Phenotypes of Offspring Born Following Hypertensive Disorders of Pregnancy: A Systematic Review
Multi‐Organ Phenotypes of Offspring Born Following Hypertensive Disorders of Pregnancy: A Systematic Review Open
Background Hypertensive pregnancies are associated with an increased risk of cardiovascular and neurological diseases in the offspring during later life. However, less is known about the potential impact on multi‐organ phenotypes in offspr…
View article: PROTEUS: A Prospective RCT Evaluating Use of AI in Stress Echocardiography
PROTEUS: A Prospective RCT Evaluating Use of AI in Stress Echocardiography Open
Background Use of artificial intelligence (AI) in cardiovascular imaging may potentially augment clinical decision-making in disease management, but no prospective randomized controlled trials have assessed the impact on cardiovascular out…
View article: Can heart failure phenotypes be predicted by cardiac remodelling peripartum or postpartum?
Can heart failure phenotypes be predicted by cardiac remodelling peripartum or postpartum? Open
Hypertension during pregnancy affects up to 10% of pregnancies and is associated with significant cardiovascular morbidity and mortality. In the short-term it can result in pre-eclampsia, haemolysis, elevated liver enzymes and low platelet…
View article: Novel Role of 5-Methyl-(6S)-Tetrahydrofolate in Mediating Endothelial Cell Tetrahydrobiopterin in Pregnancy and Implications for Gestational Hypertension
Novel Role of 5-Methyl-(6S)-Tetrahydrofolate in Mediating Endothelial Cell Tetrahydrobiopterin in Pregnancy and Implications for Gestational Hypertension Open
BACKGROUND: Folate intake during pregnancy is essential for fetal development and maternal health. However, the specific effects of folic acid (FA) and 5-methyl-(6S)-tetrahydrofolate (5-MTHF) on the prevention and treatment of hypertensive…
View article: EchoNet-Synthetic: Privacy-preserving Video Generation for Safe Medical Data Sharing
EchoNet-Synthetic: Privacy-preserving Video Generation for Safe Medical Data Sharing Open
To make medical datasets accessible without sharing sensitive patient information, we introduce a novel end-to-end approach for generative de-identification of dynamic medical imaging data. Until now, generative methods have faced constrai…
View article: 189 The national echocardiography database of the United Kingdom (NED-UK) pilot study
189 The national echocardiography database of the United Kingdom (NED-UK) pilot study Open
Background & Aim Large curated datasets of clinical echocardiographic measurements with associated interpretation are scarce. Due to standardised echocardiographic protocols and diverse patient populations, the UK offers a unique opportuni…
View article: Isometric Exercise Training and Arterial Hypertension: An Updated Review
Isometric Exercise Training and Arterial Hypertension: An Updated Review Open
Hypertension is recognised as a leading attributable risk factor for cardiovascular disease and premature mortality. Global initiatives towards the prevention and treatment of arterial hypertension are centred around non-pharmacological li…
View article: The role of exercise training on cardiovascular risk factors and heart disease in patients with chronic kidney disease G3–G5 and G5D: a Clinical Consensus Statement of the European Association of Preventive Cardiology of the ESC and the European Association of Rehabilitation in Chronic Kidney Disease
The role of exercise training on cardiovascular risk factors and heart disease in patients with chronic kidney disease G3–G5 and G5D: a Clinical Consensus Statement of the European Association of Preventive Cardiology of the ESC and the European Association of Rehabilitation in Chronic Kidney Disease Open
Cardiovascular (CV) morbidity and mortality is high in patients with chronic kidney disease (CKD). Most patients reveal a high prevalence of CV risk factors such as diabetes or arterial hypertension and many have manifest cardiovascular di…
View article: Accelerometer‐based sedentary time, light physical activity, and <scp>moderate‐to‐vigorous</scp> physical activity from childhood with arterial stiffness and carotid <scp>IMT</scp> progression: A <scp>13‐year</scp> longitudinal study of 1339 children
Accelerometer‐based sedentary time, light physical activity, and <span>moderate‐to‐vigorous</span> physical activity from childhood with arterial stiffness and carotid <span>IMT</span> progression: A <span>13‐year</span> longitudinal study of 1339 children Open
Aims We examined the longitudinal associations of sedentary time (ST), light physical activity (LPA), and moderate‐to‐vigorous PA (MVPA) from childhood with carotid‐femoral pulse wave velocity (cfPWV), a measure of arterial stiffness and c…
View article: Self-monitoring blood pressure in Pregnancy: Evaluation of health professional experiences of the BUMP trials
Self-monitoring blood pressure in Pregnancy: Evaluation of health professional experiences of the BUMP trials Open
Despite healthcare professionals' early concerns that self-monitoring of blood pressure might over-medicalise pregnancy, our analysis shows the opposite was the case when used in the care of pregnant people with, or at higher risk of, hype…
View article: Can imaging identify cardiac disease progression patterns in young people?
Can imaging identify cardiac disease progression patterns in young people? Open
View article: Beliefs, experiences and concerns of using artificial intelligence in healthcare: A qualitative synthesis
Beliefs, experiences and concerns of using artificial intelligence in healthcare: A qualitative synthesis Open
Objective Artificial intelligence (AI) is a developing field in the context of healthcare. As this technology continues to be implemented in patient care, there is a growing need to understand the thoughts and experiences of stakeholders i…
View article: Experiences of using artificial intelligence in healthcare: a qualitative study of UK clinician and key stakeholder perspectives
Experiences of using artificial intelligence in healthcare: a qualitative study of UK clinician and key stakeholder perspectives Open
Objectives Artificial intelligence (AI) is a rapidly developing field in healthcare, with tools being developed across various specialties to support healthcare professionals and reduce workloads. It is important to understand the experien…