Paul M. Arnold
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View article: The Impact of the Bypass Transport Method on Clinical Outcomes after Large Vessel Occlusion: A Pooled-Proportion Meta-Analysis
The Impact of the Bypass Transport Method on Clinical Outcomes after Large Vessel Occlusion: A Pooled-Proportion Meta-Analysis Open
This meta-analysis compares the 90-day mortality and functional outcomes between patients, and we found a statistically significant improvement in time to MT for those directly transported to a CSC; however, there was not a significant dif…
View article: Characterizing Emergency Department Visits for Product-Related Head Injuries in the United States 2014 to 2024
Characterizing Emergency Department Visits for Product-Related Head Injuries in the United States 2014 to 2024 Open
Head injury rates increased over the study period, with variation by age group. Involved products differed significantly by age group, with organized sports (football, basketball, soccer, and baseball) equipment being common in adolescents…
View article: P2. Faster fusion with P-15 peptide enhanced bone graft in TLIF: analysis of a multicenter prospective randomized controlled IDE trial
P2. Faster fusion with P-15 peptide enhanced bone graft in TLIF: analysis of a multicenter prospective randomized controlled IDE trial Open
View article: Adverse Impact of Smoking on Spine Fusion and Patient-Reported Outcomes: A Systematic Review and Meta-Analysis
Adverse Impact of Smoking on Spine Fusion and Patient-Reported Outcomes: A Systematic Review and Meta-Analysis Open
Study design Systematic review and meta-analysis. Objective This systematic review with meta-analysis is aimed at evaluating the impact of smoking (tobacco) on spinal fusion rates and the resulting PROMs. Methods Following the PRISMA guide…
View article: The sodium-glutamate antagonist riluzole improves outcome after acute spinal cord injury: results from the RISCIS randomised controlled trial analysed using a global statistical analytic technique
The sodium-glutamate antagonist riluzole improves outcome after acute spinal cord injury: results from the RISCIS randomised controlled trial analysed using a global statistical analytic technique Open
No funding was received for the present work. The original clinical trial (NCT01597518) was funded by the AO Foundation, United States Department of Defense (DOD), and the Praxis Spinal Cord Institute.
View article: Adverse Impact of Obesity on Lumbar Spine Fusion, Patient-reported Outcomes and Costs
Adverse Impact of Obesity on Lumbar Spine Fusion, Patient-reported Outcomes and Costs Open
Study Design. Systematic review and meta-analysis. Purpose. The objective of this study is to determine the impact of obesity on three key lumbar spinal surgery outcomes: the incidence of spinal nonunion, patient-reported outcome measures …
View article: A Low-Cost Articulated Arm Navigation System for External Ventricular Drain Placement
A Low-Cost Articulated Arm Navigation System for External Ventricular Drain Placement Open
Our proposed system enables real-time image-guided navigation to be used in bedside external ventricular drain placement, with potential to expand access to this procedure.
View article: Adverse Impact of Diabetes on Spine Fusion and Patient-Reported Outcomes
Adverse Impact of Diabetes on Spine Fusion and Patient-Reported Outcomes Open
Study Design. Systematic review and meta-analysis. Purpose. This meta-analysis aimed to provide a comprehensive evaluation of the impact of diabetes on spinal surgery outcomes. Background. Diabetes mellitus is believed to be associated wit…
View article: Impact of surgery and radiation on radicular pain and myotomic weakness in patients with metastatic spine disease
Impact of surgery and radiation on radicular pain and myotomic weakness in patients with metastatic spine disease Open
OBJECTIVE Surgery is typically indicated for mechanical pain in metastatic spine disease or severe neurological compromise, but how radicular pain responds to oncological treatment is not well described. The primary aim of this study was t…
View article: Advancing Metastatic Spine Tumor Research: A Review of AO Spine Knowledge Forum Tumor’s Scientific Contributions Derived From the EPOSO Network, 2014-2024
Advancing Metastatic Spine Tumor Research: A Review of AO Spine Knowledge Forum Tumor’s Scientific Contributions Derived From the EPOSO Network, 2014-2024 Open
Study Design Narrative Review. Objectives To summarize the work of the AO Spine Knowledge Forum Tumor, specifically studies from the Epidemiology, Process and Outcomes in Spine Oncology (EPOSO) study. Methods A narrative review of all publ…
View article: The economic burden of diabetes in spinal fusion surgery: a systematic review and meta-analysis
The economic burden of diabetes in spinal fusion surgery: a systematic review and meta-analysis Open
Patients with diabetes undergoing spinal fusion surgery had increased costs, prolonged LOS, increased 30-day/90-day readmission rates, and more frequent non-routine discharges.
View article: Use of Mechanical Thrombectomy versus Tissue Plasminogen Activator in Low–Middle-Income Countries: A Meta-Epidemiological Analysis of Treatment Options and Social Determinants of Health
Use of Mechanical Thrombectomy versus Tissue Plasminogen Activator in Low–Middle-Income Countries: A Meta-Epidemiological Analysis of Treatment Options and Social Determinants of Health Open
Acute ischemic stroke (AIS) is the second leading cause of death worldwide, and the disease burden falls greatly on low- and middle-income countries (LMICs) with around 63% of the global incidence. Despite medical advancements in high-inco…
View article: Joint learning of nonlinear representation and projection for fast constrained MRSI reconstruction
Joint learning of nonlinear representation and projection for fast constrained MRSI reconstruction Open
Purpose To develop and evaluate a novel method for computationally efficient reconstruction from noisy MR spectroscopic imaging (MRSI) data. Methods The proposed method features (a) a novel strategy that jointly learns a nonlinear low‐dime…
View article: Chronic pain patients’ evaluations of consultations: A matter of high expectations or expectations unmet?
Chronic pain patients’ evaluations of consultations: A matter of high expectations or expectations unmet? Open
Findings highlight the importance of exceeding multifaceted patient expectations in physician evaluations. Yet, physicians must first understand the nature and source of each patient's expectations pre-consultation, which vary across indiv…
View article: Prediction models for risk assessment of surgical site infection after spinal surgery: A systematic review
Prediction models for risk assessment of surgical site infection after spinal surgery: A systematic review Open
View article: SCAT5 baseline values, test-retest reliability, and reliable change metrics in high school athletes
SCAT5 baseline values, test-retest reliability, and reliable change metrics in high school athletes Open
OBJECTIVE In the United States, more than 1 million sport-related concussions afflict children annually, with many cases undetected or unreported. The Sport Concussion Assessment Tool (SCAT) is widely used to detect concussions in high sch…
View article: Patients May Return to Work Sooner After Laminoplasty: Occupational Outcomes of the Cervical Spondylotic Myelopathy Surgical Trial
Patients May Return to Work Sooner After Laminoplasty: Occupational Outcomes of the Cervical Spondylotic Myelopathy Surgical Trial Open
BACKGROUND AND OBJECTIVES: Return-to-work (RTW) is an important outcome for employed patients considering surgery for cervical spondylotic myelopathy (CSM). We conducted a post hoc analysis of patients as-treated in the Cervical Spondyloti…
View article: Riluzole for Degenerative Cervical Myelopathy
Riluzole for Degenerative Cervical Myelopathy Open
Importance The modified Japanese Orthopaedic Association (mJOA) scale is the most common scale used to represent outcomes of degenerative cervical myelopathy (DCM); however, it lacks consideration for neck pain scores and neglects the mult…
View article: Patient-Reported and Clinical Outcomes of Surgically Treated Patients With Symptomatic Spinal Metastases: Results From Epidemiology, Process, and Outcomes of Spine Oncology (EPOSO), a Prospective, Multi-Institutional and International Study
Patient-Reported and Clinical Outcomes of Surgically Treated Patients With Symptomatic Spinal Metastases: Results From Epidemiology, Process, and Outcomes of Spine Oncology (EPOSO), a Prospective, Multi-Institutional and International Study Open
BACKGROUND AND OBJECTIVES: The palliative impact of spine surgery for metastatic disease is evolving with improvements in surgical technique and multidisciplinary cancer care. The goal of this study was to prospectively evaluate long-term …
View article: One- and 2-year outcomes of lumbar facet arthroplasty versus spinal fusion in young (<65 years) and old (≥65 years) patients for the treatment of degenerative spondylolisthesis and stenosis
One- and 2-year outcomes of lumbar facet arthroplasty versus spinal fusion in young (<65 years) and old (≥65 years) patients for the treatment of degenerative spondylolisthesis and stenosis Open
View article: Posterior-only 2-level vertebrectomy and fusion in a medically complex patient with lumbar metastasis: illustrative case
Posterior-only 2-level vertebrectomy and fusion in a medically complex patient with lumbar metastasis: illustrative case Open
BACKGROUND Spinal metastases are commonly seen in patients with cancer and often indicate a poor prognosis. Treatment can include curative or palliative surgery, chemotherapy, and radiation therapy. The surgical approach varies widely on t…
View article: Thoracolumbar Interfascial Plane (TLIP) block verses other paraspinal fascial plane blocks and local infiltration for enhanced pain control after spine surgery: a systematic review
Thoracolumbar Interfascial Plane (TLIP) block verses other paraspinal fascial plane blocks and local infiltration for enhanced pain control after spine surgery: a systematic review Open
View article: Measuring <scp>CSF</scp> shunt flow with <scp>MRI</scp> using flow enhancement of signal intensity (<scp>FENSI</scp>)
Measuring <span>CSF</span> shunt flow with <span>MRI</span> using flow enhancement of signal intensity (<span>FENSI</span>) Open
Purpose To develop and validate a noninvasive imaging technique for accurately assessing very slow CSF flow within shunt tubes in pediatric patients with hydrocephalus, aiming to identify obstructions that might impede CSF drainage. Theory…
View article: A Clinical Practice Guideline for the Management of Patients With Acute Spinal Cord Injury: Recommendations on Hemodynamic Management
A Clinical Practice Guideline for the Management of Patients With Acute Spinal Cord Injury: Recommendations on Hemodynamic Management Open
Study Design Clinical practice guideline development following the GRADE process. Objectives Hemodynamic management is one of the only available treatment options that likely improves neurologic outcomes in patients with acute traumatic sp…
View article: A Clinical Practice Guideline for Prevention, Diagnosis and Management of Intraoperative Spinal Cord Injury: Recommendations for Use of Intraoperative Neuromonitoring and for the Use of Preoperative and Intraoperative Protocols for Patients Undergoing Spine Surgery
A Clinical Practice Guideline for Prevention, Diagnosis and Management of Intraoperative Spinal Cord Injury: Recommendations for Use of Intraoperative Neuromonitoring and for the Use of Preoperative and Intraoperative Protocols for Patients Undergoing Spine Surgery Open
Study Design Development of a clinical practice guideline following the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) process. Objective The objectives of this study were to develop guidelines that outline the …
View article: An Update of a Clinical Practice Guideline for the Management of Patients With Acute Spinal Cord Injury: Recommendations on the Role and Timing of Decompressive Surgery
An Update of a Clinical Practice Guideline for the Management of Patients With Acute Spinal Cord Injury: Recommendations on the Role and Timing of Decompressive Surgery Open
Study Design Clinical practice guideline development. Objectives Acute spinal cord injury (SCI) can result in devastating motor, sensory, and autonomic impairment; loss of independence; and reduced quality of life. Preclinical evidence sug…
View article: Prevention, Diagnosis, and Management of Intraoperative Spinal Cord Injury in the Setting of Spine Surgery: A Proposed Care Pathway
Prevention, Diagnosis, and Management of Intraoperative Spinal Cord Injury in the Setting of Spine Surgery: A Proposed Care Pathway Open
Study Design This study is a mixed methods approach. Objectives Intraoperative spinal cord injury (ISCI) is a challenging complication in spine surgery. Intra-operative neuromonitoring (IONM) has been developed to detect changes in neural …
View article: The Management of Intraoperative Spinal Cord Injury – A Scoping Review
The Management of Intraoperative Spinal Cord Injury – A Scoping Review Open
Study Design Scoping Review. Objective To review the literature and summarize information on checklists and algorithms for responding to intraoperative neuromonitoring (IONM) alerts and management of intraoperative spinal cord injuries (IS…
View article: The Use of Perioperative Liposomal Bupivacaine during Spine Surgeries Does Not Produce Improved Postoperative Pain Control in Adults: A Systematic Review
The Use of Perioperative Liposomal Bupivacaine during Spine Surgeries Does Not Produce Improved Postoperative Pain Control in Adults: A Systematic Review Open
Recovery following spinal surgery can be challenging, particularly concerning postoperative pain management. The first‐line treatment for postoperative pain is opioid analgesia, but opioid overuse can lead to adverse effects. Liposomal bup…
View article: Gender and Sex Differences in Health-related Quality of Life, Clinical Outcomes and Survival after Treatment of Metastatic Spine Disease
Gender and Sex Differences in Health-related Quality of Life, Clinical Outcomes and Survival after Treatment of Metastatic Spine Disease Open
Study Design. Retrospective review of prospective, multicenter and international cohort study. Objective. To describe the effect of gender on HRQoL, clinical outcomes and survival for patients with spinal metastases treated with either sur…