Paul M. Coen
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View article: Mitochondrial uncoupler BAM15 improves skeletal muscle function and mitochondrial respiration in Sarcopenia
Mitochondrial uncoupler BAM15 improves skeletal muscle function and mitochondrial respiration in Sarcopenia Open
Background Ageing is accompanied by progressive declines in skeletal muscle mass and strength, culminating in sarcopenia, a condition that contributes to frailty, multimorbidity, and mortality. Age-related changes to mitochondria lead to o…
View article: 12,13-diHOME protects against the age-related decline in cardiovascular function via attenuation of CaMKII
12,13-diHOME protects against the age-related decline in cardiovascular function via attenuation of CaMKII Open
View article: MicroRNA signatures of cardiorespiratory fitness (VO2peak) in older adults: Insights from the study of muscle, mobility, and aging
MicroRNA signatures of cardiorespiratory fitness (VO2peak) in older adults: Insights from the study of muscle, mobility, and aging Open
Background Peak oxygen consumption during exercise (VO2peak), is a direct measure of cardiorespiratory fitness (CF), a key indicator of physical function and overall health. However, the molecular changes that underpin VO2peak variation ar…
View article: Microgravity accelerates skeletal muscle degeneration: Functional and transcriptomic insights from an ISS muscle lab-on-chip model
Microgravity accelerates skeletal muscle degeneration: Functional and transcriptomic insights from an ISS muscle lab-on-chip model Open
View article: Cerebral Metabolic Rate of Oxygen and Accelerometry‐Based Fatigability in Community‐Dwelling Older Adults
Cerebral Metabolic Rate of Oxygen and Accelerometry‐Based Fatigability in Community‐Dwelling Older Adults Open
Alterations in energy metabolism may drive fatigue in older age, but prior research primarily focused on skeletal muscle energetics without assessing other systems and utilized self‐reported measures of fatigue. We tested the association b…
View article: Striatal Dopamine and Skeletal Muscle Energy Metabolism in Older Adults
Striatal Dopamine and Skeletal Muscle Energy Metabolism in Older Adults Open
Dopamine (DA) in the central nervous system is considered a master regulator of mobility performance and vigor, but its mechanistic relationship with skeletal muscle energetics is unclear. We tested the cross-sectional association of stria…
View article: Muscle Mitochondrial Respiration and Cardiorespiratory Fitness Contribute to Slower Walking Speed of Older Individuals Who Identify as Black
Muscle Mitochondrial Respiration and Cardiorespiratory Fitness Contribute to Slower Walking Speed of Older Individuals Who Identify as Black Open
In the United States, older adults who self‐identify as Black have a disproportionately higher incidence of mobility disability compared to those who are White. Whether older adults who are Black also have lower fitness and mitochondrial e…
View article: Serum Proteomic and Metabolomic Signatures of High Versus Low Physical Function in Octogenarians
Serum Proteomic and Metabolomic Signatures of High Versus Low Physical Function in Octogenarians Open
Physical function declines with aging, yet there is considerable heterogeneity, with some individuals declining very slowly while others experience accelerated functional decline. To gain insight into mechanisms promoting high physical fun…
View article: Microgravity Accelerates Skeletal Muscle Degeneration: Functional and Transcriptomic Insights from a Muscle Lab-on-Chip Model Onboard the ISS.
Microgravity Accelerates Skeletal Muscle Degeneration: Functional and Transcriptomic Insights from a Muscle Lab-on-Chip Model Onboard the ISS. Open
Microgravity accelerates skeletal muscle degeneration, mimicking aging, yet its effects on human muscle cell function and signaling remain underexplored. Using a muscle lab-on-chip model onboard the International Space Station, we examined…
View article: Cerebral Metabolic Rate of Oxygen and Accelerometry-Based Fatigability in Community-Dwelling Older Adults
Cerebral Metabolic Rate of Oxygen and Accelerometry-Based Fatigability in Community-Dwelling Older Adults Open
Alterations in energy metabolism may drive fatigue in older age, but prior research primarily focused on skeletal muscle energetics without assessing other systems, and utilized self-reported measures of fatigue. We tested the association …
View article: MicroRNA signatures of VO<sub>2</sub>peak in older adult participants of the Study of Muscle, Mobility and Aging
MicroRNA signatures of VO<sub>2</sub>peak in older adult participants of the Study of Muscle, Mobility and Aging Open
Background Peak oxygen consumption during exercise (VO 2 peak), is a direct measure of cardiorespiratory fitness (CF), a key indicator of physical function and overall health. However, the molecular changes that underpin VO 2 peak variatio…
View article: Associations of Elevated Red Cell Distribution Width (RDW) with Decreased Physical and Cognitive Function in Older Adults, and The Potential Mediation by Mitochondrial Energetics: The Study of Muscle, Mobility and Aging (SOMMA)
Associations of Elevated Red Cell Distribution Width (RDW) with Decreased Physical and Cognitive Function in Older Adults, and The Potential Mediation by Mitochondrial Energetics: The Study of Muscle, Mobility and Aging (SOMMA) Open
View article: Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR)
Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) Open
View article: NIGROSTRIATAL DOPAMINE AND PHYSICAL PERFORMANCE FATIGABILITY IN COMMUNITY-DWELLING OLDER ADULTS
NIGROSTRIATAL DOPAMINE AND PHYSICAL PERFORMANCE FATIGABILITY IN COMMUNITY-DWELLING OLDER ADULTS Open
Increasing nigrostriatal dopaminergic signaling can ameliorate performance fatigability in healthy young adults, but its role in community-dwelling older adults is not known. We hypothesized higher nigrostriatal dopaminergic integrity woul…
View article: MITOCHONDRIAL ENERGETICS IN SKELETAL MUSCLE ARE ASSOCIATED WITH LEG POWER AND CARDIORESPIRATORY FITNESS IN SOMMA
MITOCHONDRIAL ENERGETICS IN SKELETAL MUSCLE ARE ASSOCIATED WITH LEG POWER AND CARDIORESPIRATORY FITNESS IN SOMMA Open
Mitochondrial energetics are an important property of aging muscle, as generation of energy is pivotal to the execution of muscle contraction. However, its association with functional outcomes, including leg power and cardiorespiratory fit…
View article: DISCOVERING BIOENERGETIC AND FITNESS PROFILES OF COMBINED PERCEIVED AND PERFORMANCE FATIGABILITY
DISCOVERING BIOENERGETIC AND FITNESS PROFILES OF COMBINED PERCEIVED AND PERFORMANCE FATIGABILITY Open
Demographic characteristics, skeletal muscle energetics, cardiorespiratory fitness (VO2peak), walking energetics, physical activity, and mobility are all independently associated with perceived and performance fatigability. Perceived and p…
View article: RACE DIFFERENCES IN WALK SPEED, CARDIORESPIRATORY FITNESS, AND MUSCLE MITOCHONDRIAL RESPIRATION
RACE DIFFERENCES IN WALK SPEED, CARDIORESPIRATORY FITNESS, AND MUSCLE MITOCHONDRIAL RESPIRATION Open
Older adults who self-identify as Black have a disproportionately higher incidence of mobility disability. Whether older adults who are Black also have lower fitness and mitochondrial energetics compared to those who are White has not been…
View article: ADVERSE MUSCLE COMPOSITION IS LINKED TO LOWER MITOCHONDRIAL RESPIRATION AND SLOWER WALKING SPEED
ADVERSE MUSCLE COMPOSITION IS LINKED TO LOWER MITOCHONDRIAL RESPIRATION AND SLOWER WALKING SPEED Open
Low muscle mass and fat infiltration are core features of sarcopenic obesity. We examined skeletal muscle mitochondrial respiration and walking speed in older adults with normal muscle composition (NMC), only low muscle volume (LMV), only …
View article: SUCCESSFUL APPROACHES TO ENHANCING OLDER ADULT REPRESENTATION IN MOTRPAC TRIAL
SUCCESSFUL APPROACHES TO ENHANCING OLDER ADULT REPRESENTATION IN MOTRPAC TRIAL Open
NIH mandates that clinical research include participants of all ages (or specify a reason for excluding based on age); yet, older adults (OAs) are often underrepresented even in studies without an age exclusion. Barriers to their inclusion…
View article: RECRUITMENT OF OLDER ADULTS FOR CLINICAL RESEARCH: STRATEGIES, COSTS, AND REPRESENTATION
RECRUITMENT OF OLDER ADULTS FOR CLINICAL RESEARCH: STRATEGIES, COSTS, AND REPRESENTATION Open
Clinical research is crucial for identifying new preventative strategies and treatments to address the diverse health care needs of older adults. A necessary component of conducting ethical and unbiased research is to successfully enroll e…
View article: SKELETAL MUSCLE MITOCHONDRIAL RESPIRATION ASSOCIATES WITH COGNITIVE FUNCTION IN OLDER ADULTS
SKELETAL MUSCLE MITOCHONDRIAL RESPIRATION ASSOCIATES WITH COGNITIVE FUNCTION IN OLDER ADULTS Open
Lower skeletal muscle oxidative capacity has been linked with poor cognition in older adults. Prior studies have relied on spectroscopy assessment of post-exercise PCr recovery rate to indirectly determine muscle oxidative capacity. Here, …
View article: INTERCONNECTIONS BETWEEN COGNITION, SKELETAL MUSCLES, AND PHYSICAL FUNCTION IN ETHNICALLY DIVERSE COHORTS
INTERCONNECTIONS BETWEEN COGNITION, SKELETAL MUSCLES, AND PHYSICAL FUNCTION IN ETHNICALLY DIVERSE COHORTS Open
There is marked variability in mobility function at older ages, yet some maintain high functioning even in the face of adverse locomotor risk factors. The mechanisms underlying this resilience remain elusive, but it is clear that the centr…
View article: Sex differences in the association between skeletal muscle energetics and perceived physical fatigability: the Study of Muscle, Mobility and Aging (SOMMA)
Sex differences in the association between skeletal muscle energetics and perceived physical fatigability: the Study of Muscle, Mobility and Aging (SOMMA) Open
View article: A partial loss-of-function variant (Ile191Val) of the TAS1R2 glucose receptor is associated with enhanced responses to exercise training in older adults with obesity: A translational study
A partial loss-of-function variant (Ile191Val) of the TAS1R2 glucose receptor is associated with enhanced responses to exercise training in older adults with obesity: A translational study Open
View article: Higher Striatal Dopamine is Related With Lower Physical Performance Fatigability in Community-Dwelling Older Adults
Higher Striatal Dopamine is Related With Lower Physical Performance Fatigability in Community-Dwelling Older Adults Open
Background Fatigability in community-dwelling older adults is highly prevalent and disabling, but lacks a treatment. Greater nigrostriatal dopaminergic signaling can ameliorate performance fatigability in healthy young adults, but its role…
View article: Insulin Sensitivity and Skeletal Muscle Mitochondrial Respiration in Black and White Women With Obesity
Insulin Sensitivity and Skeletal Muscle Mitochondrial Respiration in Black and White Women With Obesity Open
Objectives Non-Hispanic Black women (BW) have a greater risk of type 2 diabetes (T2D) and insulin resistance (IR) compared to non-Hispanic White women (WW). The mechanisms leading to these differences are not understood, and it is unclear …
View article: Harmonization of experimental procedures to assess mitochondrial respiration in human permeabilized skeletal muscle fibers
Harmonization of experimental procedures to assess mitochondrial respiration in human permeabilized skeletal muscle fibers Open
Our study constitutes a basis to harmonize and establish optimum experimental conditions for respirometric studies of permeabilized human skeletal muscle fibers to improve reproducibility.
View article: Role of Walking Energetics and Perceived Fatigability Differs by Gait Speed: The Study of Muscle, Mobility and Aging (SOMMA)
Role of Walking Energetics and Perceived Fatigability Differs by Gait Speed: The Study of Muscle, Mobility and Aging (SOMMA) Open
Background Slower gait speed may be driven by greater energy deficits and fatigability among older adults. We examined associations of walking energetics and perceived physical fatigability with gait speed among slower and faster walkers. …
View article: Skeletal Muscle Composition, Power, and Mitochondrial Energetics in Older Men and Women With Knee Osteoarthritis
Skeletal Muscle Composition, Power, and Mitochondrial Energetics in Older Men and Women With Knee Osteoarthritis Open
Objective Our objective was to investigate the overall and sex‐specific relationships between the presence and severity of knee osteoarthritis (KOA) and muscle composition, power, and energetics in older adults. Methods Male and female pat…
View article: Expression of mitochondrial oxidative stress response genes in muscle is associated with mitochondrial respiration, physical performance, and muscle mass in the Study of Muscle, Mobility, and Aging
Expression of mitochondrial oxidative stress response genes in muscle is associated with mitochondrial respiration, physical performance, and muscle mass in the Study of Muscle, Mobility, and Aging Open
Gene expression in skeletal muscle of older individuals may reflect compensatory adaptations in response to oxidative damage that preserve tissue integrity and maintain function. Identifying associations between oxidative stress response g…