Paul O’Neill
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View article: Author response: Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides
Author response: Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides Open
View article: Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides
Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides Open
Antimicrobial resistance threatens the viability of modern medical interventions. There is a dire need to develop novel approaches to counter resistance mechanisms employed by starved or slow-growing pathogens that are refractory to conven…
View article: Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides
Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides Open
Antimicrobial resistance threatens the viability of modern medical interventions. There is a dire need of developing novel approaches to counter resistance mechanisms employed by starved or slow-growing pathogens that are refractory to con…
View article: Author response: Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides
Author response: Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides Open
View article: Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides
Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides Open
Antimicrobial resistance threatens the viability of modern medical interventions. There is a dire need of developing novel approaches to counter resistance mechanisms employed by starved or slow-growing pathogens that are refractory to con…
View article: Author response: Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides
Author response: Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides Open
View article: Competition with <i>Pseudomonas aeruginosa</i> induces <i>Staphylococcus aureus</i> in an antibiotic-tolerant viable but non culturable state
Competition with <i>Pseudomonas aeruginosa</i> induces <i>Staphylococcus aureus</i> in an antibiotic-tolerant viable but non culturable state Open
Interactions between different species of pathogenic microbes often affect clinical outcome by altering the virulence or antibiotic resistance of individual microbes. By investigating the interactions between Staphylococcus aureus and Pseu…
View article: Developmental defects in ectodermal appendages caused by missense mutation in edaradd gene in the nfr mangrove killifish kryptolebias marmoratus
Developmental defects in ectodermal appendages caused by missense mutation in edaradd gene in the nfr mangrove killifish kryptolebias marmoratus Open
The mangrove killifish, Kryptolebias marmoratus , can reproduce with self-fertilisation, offering a unique and useful genetic tool for generation of genetic mutants and quick identification of mutated genes. From an ENU-mutated mangrove ki…
View article: Long-term survival of asexual Zymoseptoria tritici spores in the environment
Long-term survival of asexual Zymoseptoria tritici spores in the environment Open
Background The fungal phytopathogen Zymoseptoria tritici , causal agent of the economically damaging Septoria tritici blotch of wheat, is different from most foliar fungal pathogens in that its germination occurs slowly and apparently rand…
View article: Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides
Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides Open
Antimicrobial resistance threatens the viability of modern medical interventions. There is a dire need to develop novel approaches to counter resistance mechanisms employed by starved or slow-growing pathogens that are refractory to conven…
View article: Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides
Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides Open
Antimicrobial resistance threatens the viability of modern medical interventions. There is a dire need of developing novel approaches to counter resistance mechanisms employed by starved or slow-growing pathogens that are refractory to con…
View article: Long-read transcript sequencing identifies differential isoform expression in the entorhinal cortex in a transgenic model of tau pathology
Long-read transcript sequencing identifies differential isoform expression in the entorhinal cortex in a transgenic model of tau pathology Open
Increasing evidence suggests that alternative splicing plays an important role in Alzheimer’s disease (AD) pathology. We used long-read sequencing in combination with a novel bioinformatics tool ( FICLE ) to profile transcript diversity in…
View article: Phage-induced efflux down-regulation boosts antibiotic efficacy
Phage-induced efflux down-regulation boosts antibiotic efficacy Open
The interactions between a virus and its host vary in space and time and are affected by the presence of molecules that alter the physiology of either the host or the virus. Determining the molecular mechanisms at the basis of these intera…
View article: An atlas of expressed transcripts in the prenatal and postnatal human cortex
An atlas of expressed transcripts in the prenatal and postnatal human cortex Open
Alternative splicing is a post-transcriptional mechanism that increases the diversity of expressed transcripts and plays an important role in regulating gene expression in the developing central nervous system. We used long-read transcript…
View article: Developmental defects in ectodermal appendages caused by missense mutation in<i>edaradd</i>gene in the<i>nfr</i>mangrove killifish,<i>Kryptolebias marmoratus</i>
Developmental defects in ectodermal appendages caused by missense mutation in<i>edaradd</i>gene in the<i>nfr</i>mangrove killifish,<i>Kryptolebias marmoratus</i> Open
From an ENU-mutated mangrove killifish line R228, we have identified and isolated a novel mutant line, no-fin-ray/ nfr in which fin ray development is largely reduced. Besides the reduction of the fin, the nfr mutant also exhibited other p…
View article: Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides
Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides Open
Antimicrobial resistance threatens the viability of modern medical interventions. There is a dire need of developing novel approaches to counter resistance mechanisms employed by starved or slow-growing pathogens that are refractory to con…
View article: Long-term survival of asexual<i>Zymoseptoria tritici</i>spores in the environment
Long-term survival of asexual<i>Zymoseptoria tritici</i>spores in the environment Open
The fungal phytopathogen Zymoseptoria tritici , causal agent of the economically damaging Septoria tritici blotch of wheat, is different from most foliar fungal pathogens in that its germination occurs slowly and apparently randomly after …
View article: Targeted bisulfite sequencing analysis of Alzheimer’s disease candidate genes reveals differential methylation across neurofibrillary tangle burden in the prefrontal cortex.
Targeted bisulfite sequencing analysis of Alzheimer’s disease candidate genes reveals differential methylation across neurofibrillary tangle burden in the prefrontal cortex. Open
Background Recent epigenome‐wide association studies (EWAS) identified several loci in specific genes showing robust and reproducible alterations in DNA methylation in Alzheimer’s disease (AD) brain samples. Standardly, assessing methylati…
View article: Phage-induced efflux down-regulation boosts antibiotic efficacy
Phage-induced efflux down-regulation boosts antibiotic efficacy Open
Summary The interactions between a virus and its host vary in space and time and are affected by the presence of molecules that alter the physiology of either the host or the virus. Determining the molecular mechanisms underpinning these i…
View article: The Arabinose 5-Phosphate Isomerase KdsD Is Required for Virulence in Burkholderia pseudomallei
The Arabinose 5-Phosphate Isomerase KdsD Is Required for Virulence in Burkholderia pseudomallei Open
The intrinsic resistance of B. pseudomallei to many antibiotics complicates treatment. This opportunistic pathogen possesses a wide range of virulence factors, resulting in severe and potentially fatal disease.
View article: Optimised protocol for monitoring SARS-CoV-2 in wastewater using reverse complement PCR-based whole-genome sequencing
Optimised protocol for monitoring SARS-CoV-2 in wastewater using reverse complement PCR-based whole-genome sequencing Open
Monitoring the spread of viral pathogens in the population during epidemics is crucial for mounting an effective public health response. Understanding the viral lineages that constitute the infections in a population can uncover the origin…
View article: Nutrient and salt depletion synergistically boosts glucose metabolism in individual Escherichia coli cells
Nutrient and salt depletion synergistically boosts glucose metabolism in individual Escherichia coli cells Open
View article: Nutrient and salt depletion synergistically boosts glucose metabolism in individual bacteria
Nutrient and salt depletion synergistically boosts glucose metabolism in individual bacteria Open
The interaction between a cell and its environment shapes fundamental intracellular processes such as cellular metabolism. In most cases growth rate is treated as a proximal metric for understanding the cellular metabolic status. However, …
View article: Molecular mechanisms of embryonic tail development in the self-fertilizing mangrove killifish <i>Kryptolebias marmoratus</i>
Molecular mechanisms of embryonic tail development in the self-fertilizing mangrove killifish <i>Kryptolebias marmoratus</i> Open
Using the self-fertilizing mangrove killifish, we characterized two mutants, shorttail (stl) and balltail (btl). These mutants showed abnormalities in the posterior notochord and muscle development. Taking advantage of a highly inbred isog…
View article: Full-length transcript sequencing of human and mouse cerebral cortex identifies widespread isoform diversity and alternative splicing
Full-length transcript sequencing of human and mouse cerebral cortex identifies widespread isoform diversity and alternative splicing Open
View article: Supporting the use of adjuvant radiotherapy in recurrent pleomorphic adenoma of the parotid
Supporting the use of adjuvant radiotherapy in recurrent pleomorphic adenoma of the parotid Open
The use of adjuvant radiotherapy remains controversial in the treatment of recurrent pleomorphic adenomas. The aim of this study was to provide the highest level of evidence possible by performing a systematic review and meta-analysis of t…
View article: Persister Escherichia coli Cells Have a Lower Intracellular pH than Susceptible Cells but Maintain Their pH in Response to Antibiotic Treatment
Persister Escherichia coli Cells Have a Lower Intracellular pH than Susceptible Cells but Maintain Their pH in Response to Antibiotic Treatment Open
Persister and VBNC cells can phenotypically survive environmental stressors, such as antibiotic treatment, limitation of nutrients, and acid stress, and have been linked to chronic infections and antimicrobial resistance. It has recently b…
View article: Supporting the use of adjuvant radiotherapy in recurrent pleomorphic adenoma of the parotid
Supporting the use of adjuvant radiotherapy in recurrent pleomorphic adenoma of the parotid Open
The use of adjuvant radiotherapy remains controversial in the treatment of recurrent pleomorphic adenomas. The aim of this study was to provide the highest level of evidence possible by performing a systematic review and meta-analysis of t…
View article: Full-length transcript sequencing of human and mouse identifies widespread isoform diversity and alternative splicing in the cerebral cortex
Full-length transcript sequencing of human and mouse identifies widespread isoform diversity and alternative splicing in the cerebral cortex Open
Alternative splicing is a post-transcriptional regulatory mechanism producing multiple distinct mRNA molecules from a single pre-mRNA. Alternative splicing has a prominent role in the central nervous system, impacting neurodevelopment and …
View article: Transcriptional Signatures of Tau and Amyloid Neuropathology
Transcriptional Signatures of Tau and Amyloid Neuropathology Open
Alzheimer's disease (AD) is associated with the intracellular aggregation of hyperphosphorylated tau and the accumulation of β-amyloid in the neocortex. We use transgenic mice harboring human tau (rTg4510) and amyloid precursor protein (J2…