Anthony P. Marsh
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Association Between Contrast Sensitivity and Physical Function in Cognitively Healthy Older Adults: The Brain Networks and Mobility Function Study Open
Background To evaluate whether contrast sensitivity is associated with lower extremity physical function in cognitively intact older adults. Methods Cross-sectional analysis of the relationship of binocular and worse eye log contrast sensi…
Exercise Modality Affects Older Adult CT-Derived Muscle and Bone Loss During Caloric Restriction Open
Caloric restriction (CR) can exacerbate muscle and bone loss. We examined 18-month changes in computed tomography (CT)-derived trunk muscle, and volumetric bone mineral density (vBMD) and finite element-estimated bone strength of the spine…
Kinematics of gait in Golden Retriever Muscular Dystrophy Open
The goal of this study was to quantify the two-dimensional kinematics of pathologic gait during overground walking at a self-selected speed at the stifle (knee) and hock (ankle) joints in six Golden Retriever Muscular Dystrophy (GRMD) dogs…
Dietary Weight Loss, Exercise, and Inflammation in Older Adults with Overweight or Obesity and Cardiometabolic Disease Open
Objective This study aimed to examine exercise modality during weight loss on change in inflammation among older adults with overweight or obesity and cardiometabolic disease. Methods A total of 222 older adults with a mean (SD) age of 66.…
Effect of Weight Change Following Intentional Weight Loss on Bone Health in Older Adults with Obesity Open
Objective This study aimed to examine change in bone mineral density (BMD) and trabecular bone score among older adult weight regainers (WR) and weight maintainers (WM). Methods Observational data come from 77 older adults (mean age: 67 [S…
Effect of Hospitalizations on Physical Activity Patterns in Mobility‐Limited Older Adults Open
OBJECTIVES To evaluate the effect of hospitalizations on patterns of sedentary and physical activity time in mobility‐limited older adults randomized to structured physical activity or health education. DESIGN Secondary analysis of investi…
Self‐Reported Physical Function As a Predictor of Hospitalization in the Lifestyle Interventions and Independence for Elders Study Open
Objectives To explore whether baseline scores on the Mobility Assessment Tool—short form (MAT‐sf), a brief, animated, computer‐based means of assessing mobility that predicts mobility disability, are associated with number of hospitalizati…
Effect of Exercise Modality During Weight Loss on Bone Health in Older Adults With Obesity and Cardiovascular Disease or Metabolic Syndrome: A Randomized Controlled Trial Open
The objective of this study was to determine the ability of either aerobic or resistance training to counter weight-loss-associated bone loss in older adults. There were 187 older adults (67 years, 70% women, 64% white) with obesity (BMI =…
Gait Speed and Mobility Disability: Revisiting Meaningful Levels in Diverse Clinical Populations Open
Objectives To investigate the heterogeneity of clinically meaningful levels of gait speed relative to self‐reported mobility disability (SR‐MD). Design Five longitudinal studies with older adults in different health states (onset of acute …
Relationship of Physical Function to Single Muscle Fiber Contractility in Older Adults: Effects of Resistance Training With and Without Caloric Restriction Open
Single muscle fiber force and knee extensor quality improve with RT and RT+CR; however, CR does not enhance improvements in single muscle fiber contractility or whole muscle in response to RT in older overweight and obese men and women.
Maintenance of Physical Function 1 Year After Exercise Intervention in At-Risk Older Adults: Follow-up From the LIFE Study Open
Although sedentary at-risk older adults increased their physical activity during a structured physical activity intervention, they did not continue at this level following the cessation of intervention. Future exercise interventions need t…
View article: Association of Accelerometry‐Measured Physical Activity and Cardiovascular Events in Mobility‐Limited Older Adults: The LIFE (Lifestyle Interventions and Independence for Elders) Study
Association of Accelerometry‐Measured Physical Activity and Cardiovascular Events in Mobility‐Limited Older Adults: The LIFE (Lifestyle Interventions and Independence for Elders) Study Open
Background Data are sparse regarding the value of physical activity ( PA ) surveillance among older adults—particularly among those with mobility limitations. The objective of this study was to examine longitudinal associations between obj…
Effect of Exercise Type During Intentional Weight Loss on Body Composition in Older Adults with Obesity Open
Objective To examine the long‐term effects of exercise modality during weight loss on body composition and associations between body composition and physical function changes. Methods Two hundred forty‐nine older adults (66.9 ± 4.7 years, …
Dose of physical activity, physical functioning and disability risk in mobility-limited older adults: Results from the LIFE study randomized trial Open
ClinicalsTrials.gov NCT00116194.
Device‐Measured Physical Activity As a Predictor of Disability in Mobility‐Limited Older Adults Open
Objectives To examine associations between objectively measured physical activity ( PA ) and incidence of major mobility disability ( MMD ) and persistent MMD ( PMMD ) in older adults in the Lifestyle Interventions and Independence for Eld…
Assessing balance through the use of a low-cost head-mounted display in older adults: a pilot study Open
This VRHMD is both affordable and portable, causes minimal simulator sickness, and produces repeatable results that can be used to assess balance in older adults.
Exercise's effect on mobility disability in older adults with and without obesity: The LIFE study randomized clinical trial Open
Objective Some data suggest that obesity blunts the benefits of exercise on mobility in older adults. This study tested the homogeneity of the effect of a physical activity intervention on major mobility disability (MMD) across baseline ob…
Evaluating Accelerometry Thresholds for Detecting Changes in Levels of Moderate Physical Activity and Resulting Major Mobility Disability Open
Accelerometry assessment within the LIFE study was not sensitive to change in level in physical activity for older adults with very low levels of physical function. A combination of self-report and objective measures are recommended for us…
Change in Bone Mineral Density During Weight Loss with Resistance Versus Aerobic Exercise Training in Older Adults Open
Results suggest performing resistance, rather than aerobic, training during CR may attenuate loss of hip and femoral neck BMD in overweight and obese older adults. Findings warrant replication from a long-term, adequately powered, RCT.
Circulating MiRNAs as biomarkers of gait speed responses to aerobic exercise training in obese older adults Open
Gait speed is a useful predictor of adverse outcomes, including incident mobility disability and mortality in older adults. While aerobic exercise training (AEX) is generally an effective therapy to improve gait speed, individual responses…