Paul Maruff
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View article: Remote, self-administered, smartphone cognitive testing in a registry-based cohort: Feasibility, reliability, and validity findings
Remote, self-administered, smartphone cognitive testing in a registry-based cohort: Feasibility, reliability, and validity findings Open
Background Remote, smartphone-based cognitive testing may improve access to cognitive assessments for Alzheimer’s disease and related dementias. We evaluated the feasibility, reliability, and validity of unsupervised smartphone-based cogni…
View article: Association between anxiety, stress, and cognition in middle-aged adults at risk for Alzheimer's disease: Results from the Healthy Brain Project
Association between anxiety, stress, and cognition in middle-aged adults at risk for Alzheimer's disease: Results from the Healthy Brain Project Open
Anxiety symptoms may be linked to a heightened risk of developing cognitive impairment in midlife. Somatic symptoms and excessive worry may play a particularly strong role in mediating this association.
View article: Exploring the relationship between methylation of the cortisol receptor genes and brain and cognitive outcomes in individuals with elevated amyloid-β
Exploring the relationship between methylation of the cortisol receptor genes and brain and cognitive outcomes in individuals with elevated amyloid-β Open
Chronic stress has been implicated as a risk factor for Alzheimer’s disease (AD), although the molecular pathways linking stress with AD are poorly understood. In this study, relationships between differential methylation of the cortisol r…
View article: A large-scale multi-centre study characterising atrophy heterogeneity in Alzheimer’s disease
A large-scale multi-centre study characterising atrophy heterogeneity in Alzheimer’s disease Open
View article: Amyloid accumulation, brain atrophy, and cognitive decline in emergent Alzheimer's disease
Amyloid accumulation, brain atrophy, and cognitive decline in emergent Alzheimer's disease Open
INTRODUCTION Emergent Alzheimer's disease (AD) represents a transitional stage where cognitively unimpaired (CU) individuals exhibit subthreshold but increasing amyloid‐β (Aβ) levels. The impact of Aβ accumulation on brain volume loss and …
View article: 0812 Use of the Psychomotor Vigilance Test in Clinical Trials of CNS-Active Drugs: A Systematic Review and Meta-analysis
0812 Use of the Psychomotor Vigilance Test in Clinical Trials of CNS-Active Drugs: A Systematic Review and Meta-analysis Open
Introduction People with central disorders of hypersomnolence (CDH) experience difficulties with sustained attention and associated difficulties in daily living. The Psychomotor Vigilance Test (PVT) is used widely to measure impairment in …
View article: 0811 Characterizing Patient-Reported Cognitive Symptoms and Their Impact on Daily Life in Narcolepsy Type 1
0811 Characterizing Patient-Reported Cognitive Symptoms and Their Impact on Daily Life in Narcolepsy Type 1 Open
Introduction Narcolepsy type 1 (NT1) is a chronic, rare neurological disorder with a significant impact on daily life. It is characterized by a pentad of symptoms including excessive daytime sleepiness (EDS), cataplexy, disrupted nighttime…
View article: 0137 Utility of a Smartphone Assessment of Alertness and Decision Making for Real World Nighttime Waking Studies
0137 Utility of a Smartphone Assessment of Alertness and Decision Making for Real World Nighttime Waking Studies Open
Introduction Development of novel sleep promoting drugs requires demonstration that individuals sleeping, after having taken the drug at therapeutic doses, can be awoken by an unforeseen important event. Overnight waking studies require a …
View article: Machine learning reveals distinct neuroanatomical signatures of cardiovascular and metabolic diseases in cognitively unimpaired individuals
Machine learning reveals distinct neuroanatomical signatures of cardiovascular and metabolic diseases in cognitively unimpaired individuals Open
Comorbid cardiovascular and metabolic risk factors (CVM) differentially impact brain structure and increase dementia risk, but their specific magnetic resonance imaging signatures (MRI) remain poorly characterized. To address this, we deve…
View article: Predicting amyloid beta accumulation in cognitively unimpaired older adults: Cognitive assessments provide no additional utility beyond demographic and genetic factors
Predicting amyloid beta accumulation in cognitively unimpaired older adults: Cognitive assessments provide no additional utility beyond demographic and genetic factors Open
BACKGROUND Integrating non‐invasive measures to estimate abnormal amyloid beta accumulation (Aβ+) is key to developing a screening tool for preclinical Alzheimer's disease (AD). The predictive capability of standard neuropsychological test…
View article: Rethinking the residual approach: leveraging statistical learning to operationalize cognitive resilience in Alzheimer’s disease
Rethinking the residual approach: leveraging statistical learning to operationalize cognitive resilience in Alzheimer’s disease Open
View article: An Acetylcholine M<sub>1</sub> Receptor–Positive Allosteric Modulator (TAK-071) in Parkinson Disease With Cognitive Impairment
An Acetylcholine M<sub>1</sub> Receptor–Positive Allosteric Modulator (TAK-071) in Parkinson Disease With Cognitive Impairment Open
Importance Fall risk and cognitive impairment are prevalent and burdensome in Parkinson disease (PD), requiring efficacious, well-tolerated treatment. Objective To evaluate the safety and efficacy of TAK-071, a muscarinic acetylcholine M 1…
View article: Clinical Pharmacology and Approach to Dose Selection of Emestedastat, a Novel Tissue Cortisol Synthesis Inhibitor for the Treatment of Central Nervous System Disease
Clinical Pharmacology and Approach to Dose Selection of Emestedastat, a Novel Tissue Cortisol Synthesis Inhibitor for the Treatment of Central Nervous System Disease Open
This review demonstrates the value of central pharmacodynamics (PD), including positron emission tomography (PET) and computerized cognitive testing, to supplement pharmacokinetic (PK) and peripheral PD for determining the target dose rang…
View article: Exploring the relationship between melanopsin gene variants, sleep, and markers of brain health
Exploring the relationship between melanopsin gene variants, sleep, and markers of brain health Open
INTRODUCTION Melanopsin is a photopigment with roles in mediating sleep and circadian‐related processes, which are often disrupted in Alzheimer's disease (AD). Melanopsin also impacts cognition and synaptogenesis. This study investigated t…
View article: Sex differences in the association between episodic memory residual reserve index and change in executive function
Sex differences in the association between episodic memory residual reserve index and change in executive function Open
View article: Evaluation of effect of cooled haemodialysis on cognition in patients with end-stage kidney disease (ECHECKED) feasibility randomised controlled trial results
Evaluation of effect of cooled haemodialysis on cognition in patients with end-stage kidney disease (ECHECKED) feasibility randomised controlled trial results Open
Background Cognitive impairment is common in haemodialysis patients with no known beneficial interventions. Cooler dialysate slows brain white-matter changes, but its effect on cognition is unknown. This feasibility trial was performed to …
View article: The relationship between genetic variation in Aquaporin-4, sleep quality measures and Alzheimer’s disease-related phenotypes.
The relationship between genetic variation in Aquaporin-4, sleep quality measures and Alzheimer’s disease-related phenotypes. Open
Genetic variants within the Aquaporin-4 gene (AQP4) have been associated with Alzheimer’s disease (AD) diagnosis, rate of cognitive decline, and brain amyloid-β (Aβ) burden. Additionally, AQP4 variants have been reported to moderate the re…
View article: Developing a machine learning stack model to forecast the progression of mild cognitive impairment to Alzheimer’s dementia, using the Australian Imaging, Biomarker & Lifestyle (AIBL) Study dataset
Developing a machine learning stack model to forecast the progression of mild cognitive impairment to Alzheimer’s dementia, using the Australian Imaging, Biomarker & Lifestyle (AIBL) Study dataset Open
Background Alzheimer’s disease (AD) is a progressive neurodegenerative condition, with considerable variation in disease progression from the mild cognitive impairment (MCI) stage. Predicting disease progression will support prognostic dec…
View article: Rethinking the residual approach for estimating cognitive resilience and resistance to AD pathology
Rethinking the residual approach for estimating cognitive resilience and resistance to AD pathology Open
Background The residual approach has found wide application in researching cognitive resilience, a phenomenon conceptually understood as cognitive performance being better‐than‐typical for an individual, despite apparent AD pathology. The …
View article: Associations between BDNF Val66Met and tau‐PET and episodic memory performance in sporadic AD
Associations between BDNF Val66Met and tau‐PET and episodic memory performance in sporadic AD Open
Background In the presence of abnormally high amyloid (Aβ+), carriage of the brain‐derived neurotrophic factor (BDNF) Val66Met polymorphism Met allele (Met66) is associated with faster clinical disease progression, greater neuronal loss an…
View article: Learning deficits in late middle‐aged <i>APOE</i> ε4 carriers: Implications for emergent Alzheimer’s disease
Learning deficits in late middle‐aged <i>APOE</i> ε4 carriers: Implications for emergent Alzheimer’s disease Open
Background Recent studies suggest learning deficits are the earliest cognitive abnormality to emerge in Alzheimer’s disease (AD). Using the Online Repeatable Cognitive Assessment‐Language Learning Test (ORCA‐LLT), cognitively unimpaired (C…
View article: Association of basal forebrain atrophy with cognitive decline in early Alzheimer’s disease
Association of basal forebrain atrophy with cognitive decline in early Alzheimer’s disease Open
Background In early Alzheimer’s disease (AD), amyloid‐β (Aβ) accumulation is associated with volume loss in the basal forebrain (BF) and cognitive decline. However, the extent to which Aβ‐related BF atrophy manifests as cognitive decline i…
View article: Association of basal forebrain atrophy with cognitive decline in early Alzheimer’s disease
Association of basal forebrain atrophy with cognitive decline in early Alzheimer’s disease Open
Background In early Alzheimer’s disease (AD), amyloid‐β (Aβ) accumulation is associated with volume loss in the basal forebrain (BF) and cognitive decline. However, the extent to which Aβ‐related BF atrophy manifests as cognitive decline i…
View article: Developing a machine learning stack model to forecast the progression of mild cognitive impairment to Alzheimer’s dementia, using the Australian Imaging, Biomarker & Lifestyle (AIBL) Study dataset
Developing a machine learning stack model to forecast the progression of mild cognitive impairment to Alzheimer’s dementia, using the Australian Imaging, Biomarker & Lifestyle (AIBL) Study dataset Open
Background Alzheimer’s disease (AD) is a progressive neurodegenerative condition, with considerable variation in disease progression from the mild cognitive impairment (MCI) stage. Predicting disease progression will support prognostic dec…
View article: Acceptability and validity of the smartphone‐administered version of the Cogstate Brief Battery in middle‐aged and older adults of the Healthy Brain Project
Acceptability and validity of the smartphone‐administered version of the Cogstate Brief Battery in middle‐aged and older adults of the Healthy Brain Project Open
Background Remote and unsupervised administration of neuropsychological tests may increase opportunities to understand cognition in everyday life compared to in‐clinic assessments. The technological sophistication and widespread use of sma…
View article: Acceptability and validity of a smartphone‐administered word list learning test, LILA, in cognitively unimpaired adults
Acceptability and validity of a smartphone‐administered word list learning test, LILA, in cognitively unimpaired adults Open
Background The International Shopping List Test (ISLT) is a rater‐administered verbal list learning test, sensitive to memory dysfunction in early Alzheimer’s disease (AD). This study examined the acceptability of a self‐administered ISLT …
View article: Development of Xanamem, an isoform 1 specific inhibitor of 11‐βHSD, as a procognitive and disease modifying treatment for mild/moderate Alzheimer’s disease. A pharmacodynamic and biomarker driven approach
Development of Xanamem, an isoform 1 specific inhibitor of 11‐βHSD, as a procognitive and disease modifying treatment for mild/moderate Alzheimer’s disease. A pharmacodynamic and biomarker driven approach Open
Background Selecting the optimal dose for clinical development is especially problematic for drugs directed at CNS‐specific targets. For drugs with a novel mechanism of action, these problems are often greater. We describe Xanamem’s clinic…
View article: Exploring how genetic variation within Aquaporin‐4, influences the relationship between sleep and amyloid beta
Exploring how genetic variation within Aquaporin‐4, influences the relationship between sleep and amyloid beta Open
Background The glymphatic system has been suggested as an important clearance mechanism for amyloid‐β (Aβ) during sleep. Animal and cellular models have suggested this clearance mechanism involves the water‐channel protein, Aquaporin‐4 (en…
View article: Harmonization of data from neuropsychological tests used in different prospective studies‐ Descending a Tower of Babel
Harmonization of data from neuropsychological tests used in different prospective studies‐ Descending a Tower of Babel Open
Background Cognitive dysfunction is central to clinicopathological models of Alzheimer’s disease (AD). While AD prospective studies assess similar cognitive domains, the neuropsychological tests used vary between studies, limiting potentia…
View article: Cross‐cohort epigenome‐wide association study in Alzheimer’s disease risk and related traits
Cross‐cohort epigenome‐wide association study in Alzheimer’s disease risk and related traits Open
Background Epigenome‐wide association studies (EWAS) have identified multiple loci that are differentially methylated in Alzheimer’s disease (AD). However, for complex diseases such as AD, single methylation sites associated with disease a…