Paul Moorehead
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View article: Exorcizing the devil of factor VIII inhibitors
Exorcizing the devil of factor VIII inhibitors Open
View article: Access to innovative therapies in pediatric oncology: Report of the nationwide experience in Canada
Access to innovative therapies in pediatric oncology: Report of the nationwide experience in Canada Open
Background The need for new therapies to improve survival and outcomes in pediatric oncology along with the lack of approval and accessible clinical trials has led to “out‐of‐trial” use of innovative therapies. We conducted a retrospective…
View article: Pediatric pulmonary thromboembolism: a 3-year Canadian Pediatric Surveillance Program study
Pediatric pulmonary thromboembolism: a 3-year Canadian Pediatric Surveillance Program study Open
View article: Extracellular vesicle small RNA cargo discriminates non-cancer donors from pediatric B-lymphoblastic leukemia patients
Extracellular vesicle small RNA cargo discriminates non-cancer donors from pediatric B-lymphoblastic leukemia patients Open
Pediatric B-acute lymphoblastic leukemia (B-ALL) is a disease of abnormally growing B lymphoblasts. Here we hypothesized that extracellular vesicles (EVs), which are nanosized particles released by all cells (including cancer cells), could…
View article: 86 Incidence of Pulmonary Thromboembolism in Canadian Children: A 3-Year National Surveillance Study
86 Incidence of Pulmonary Thromboembolism in Canadian Children: A 3-Year National Surveillance Study Open
Introduction/Background Pulmonary thromboembolism (PTE) is a rare but life-threatening event for which adequate epidemiological data in paediatrics are lacking. Best estimates regarding the epidemiology of PTE in Canadian children were pub…
View article: BATs in the hematology belfry
BATs in the hematology belfry Open
In this issue of Haemophilia, Sharma and colleagues describe a quality improvement initiative to introduce a bleeding assessment tool (BAT), specifically a self-administered (rather than expert-administered) electronic BAT (e self-BAT), in…
View article: Emicizumab in people with moderate or mild haemophilia A (HAVEN 6): a multicentre, open-label, single-arm, phase 3 study
Emicizumab in people with moderate or mild haemophilia A (HAVEN 6): a multicentre, open-label, single-arm, phase 3 study Open
View article: Transition from pediatric to adult aftercare for survivors of pediatric cancer in Newfoundland and Labrador: a qualitative study
Transition from pediatric to adult aftercare for survivors of pediatric cancer in Newfoundland and Labrador: a qualitative study Open
We found that there was little preparation for the transition of CCSs into adult care, and their aftercare was disrupted. Programs serving CCSs have opportunities to improve care by standardizing and better supporting these transitions, fo…
View article: Recombinant Factor VIII Fc Inhibits B Cell Activation via Engagement of the FcγRIIB Receptor
Recombinant Factor VIII Fc Inhibits B Cell Activation via Engagement of the FcγRIIB Receptor Open
The development of neutralizing antibodies (inhibitors) against factor VIII (FVIII) is a major complication of hemophilia A treatment. The sole clinical therapy to restore FVIII tolerance in patients with inhibitors remains immune toleranc…
View article: Standardizing the categorizations of models of aftercare for survivors of childhood cancer
Standardizing the categorizations of models of aftercare for survivors of childhood cancer Open
View article: The truth about going home
The truth about going home Open
Today she’s a state. We’ve spent all day in clinic topping her up with blood products and narcotics. It’s Friday, and we’re trying to mend her well enough to last through the weekend. Everything is done, her line is locked, and her mom is …
View article: Interventions to improve the aftercare of survivors of childhood cancer: A systematic review
Interventions to improve the aftercare of survivors of childhood cancer: A systematic review Open
Purpose: This systematic review summarizes the evidence for the effectiveness of interventions aimed at improving the experiences and outcomes for childhood cancer survivors (CCS). Design: We performed a structured literature search of Pub…
View article: A Practical Guide to the Management of the Fetus and Newborn With Hemophilia
A Practical Guide to the Management of the Fetus and Newborn With Hemophilia Open
Newborns with hemophilia are at risk of intracranial hemorrhage, extracranial hemorrhage, and other bleeding complications. The safe delivery of a healthy newborn with hemophilia is a complex process that can begin even before conception, …
View article: Correction to: The association of venous thromboembolism with survival in pediatric cancer patients: a population-based cohort study
Correction to: The association of venous thromboembolism with survival in pediatric cancer patients: a population-based cohort study Open
View article: Dexamethasone promotes durable factor VIII-specific tolerance in hemophilia A mice via thymic mechanisms
Dexamethasone promotes durable factor VIII-specific tolerance in hemophilia A mice via thymic mechanisms Open
The development of inhibitory antibodies to factor VIII is the most serious complication of replacement therapy in hemophilia A. Activation of the innate immune system during exposure to this protein contributes to inhibitor development. H…
View article: The worst thing
The worst thing Open
The worst thing is the feeling that everyone knows. Knows how I’m feeling, knows what’s going on in my head. They’re second-guessing me, doubting me, because they can see the shambles inside me. They must know. There’s this kid at work, no…
View article: Concurrent influenza vaccination reduces anti-FVIII antibody responses in murine hemophilia A
Concurrent influenza vaccination reduces anti-FVIII antibody responses in murine hemophilia A Open
Key Points Vaccination against influenza, with and without the adjuvant MF59, decreases the risk of inhibitor development in HA mice. Decreased FVIII immunogenicity may be attributed to antigenic competition via T-cell chemotaxis toward th…
View article: A peculiar chimera
A peculiar chimera Open
Health Care Federalism in Canada: Critical Junctures and Critical Perspectives. Katherine Fierlbeck, William Lahey, editors McGill–Queen’s University Press; 2013. One chapter into Health Care Federalism in Canada: Critical Junctures and Cr…
View article: Engineering regulatory T cells against factor VIII inhibitors
Engineering regulatory T cells against factor VIII inhibitors Open
In this issue of Blood , Kim et al show that engineered factor VIII (FVIII)-specific regulatory T cells inhibit immune responses to FVIII,[1][1] suggesting the possibility of cellular therapy for FVIII inhibitors in hemophilia A.
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