Explanipedia

Diagnostic Accuracy of the Rapid Human Papillomavirus Oncoprotein E6/E7 Antigen Test for Cervical Cancer Screening in a Low-Resource Setting: A Cross-Sectional Study Open

Talai KC, Patel Apurva A, Itsura PM, Banchir RM, M Kapten , et al. · 2025

Background: Persistent high-risk human papillomavirus is responsible for 95% of all cases of cervical cancer worldwide. Screening for high-risk genotypes has been acknowledged as the gold standard for the elimination of cervical cancer. Ho…

Cost-effectiveness of intrapartum azithromycin to prevent maternal infection, sepsis, or death in low-income and middle-income countries: a modelling analysis of data from a randomised, multicentre, placebo-controlled trial Open

Jackie K. Patterson, Simon Neuwahl, S. Kirsch, Janet Moore, Alan Tita , et al. · 2025

Eunice Kennedy Shriver National Institute of Child Health and Human Development and the Foundation for the National Institutes of Health through the Maternal, Newborn, and Child Health Discovery and Tools Initiative of the Bill & Melinda G…

Effectiveness of intrapartum azithromycin to prevent infections in planned vaginal births in low-income and middle-income countries: a post-hoc analysis of data from a multicentre, randomised, double-blind, placebo-controlled trial Open

Waldemar A. Carlo, Alan Tita, Janet Moore, Musaku Mwenechanya, Elwyn Chomba , et al. · 2025

For the French and Spanish translations of the abstract see Supplementary Materials section.

Effects on maternal and pregnancy outcomes of first-trimester malaria infection among nulliparous women from Kenya, Zambia, and the Democratic Republic of the Congo Open

Leuba S.I, Daniel Westreich, Bose C.L., Olshan A.F, Torres S.M , et al. · 2025

Background Few studies have assessed the impact of first-trimester malaria infection during pregnancy. We estimated this impact on adverse maternal and pregnancy outcomes. Methods In a convenience sample of women from the ASPIRIN (Aspirin …

Effects on maternal and pregnancy outcomes of first-trimester malaria infection among nulliparous women from Kenya, Zambia, and the Democratic Republic of the Congo Open

Sequoia I. Leuba, Daniel Westreich, Carl Bose, Andrew F. Olshan, Steve M. Taylor , et al. · 2024

Background Few studies have assessed the impact of first-trimester malaria infection during pregnancy. We estimated this impact on adverse maternal and pregnancy outcomes. Methods In a convenience sample of women from the ASPIRIN (Aspirin …

Prediction of Outcomes in Infants with Hydrops Fetalis by Mode of Delivery: A Retrospective Cohort from a Low-Resource Setting in Kenya Open

Poli Philippe Amubuomombe, Wycliffe Kosgei, P. K, Richard Mogeni, K. Mutindi , et al. · 2024

BACKGROUND Hydrops fetalis is a condition associated with increased perinatal and neonatal mortality and morbidity. The overall survival rate of infants diagnosed with hydrops fetalis is currently estimated to be 27%, despite advanced intr…

Corrigendum to The impact of risk factors on aspirin's efficacy for the prevention of preterm birth. American Journal of Obstetrics & Gynecology MFM. Volume 5, Issue 10, October 2023, 101095 Open

Emily Nuss, Matthew Hoffman, Shivaprasad S. Goudar, Avinash Kavi, Mrityunjay Metgud , et al. · 2024

The impact of risk factors on aspirin's efficacy for the prevention of preterm birth Open

Emily Nuss, Matthew Hoffman, Shivaprasad S. Goudar, Avinash Kavi, Mrityunjay Metgud , et al. · 2024

BACKGROUND: The Aspirin Supplementation for Pregnancy Indicated Risk Reduction In Nulliparas trial was a landmark study that demonstrated a reduction in preterm birth and hypertensive disorders of pregnancy in nulliparous women who receive…

Factors associated with utilization of skilled birth attendance among women of reproductive age in North Horr Sub-County, Northern Kenya, 2021 Open

Qabale Anna Duba, Elvis Oyugi, Paul Nyongesa, Joseph Obiero Ogutu · 2024

Introduction: One of the ways of reducing the maternal mortality ratio (MMR) is through skilled birth attendance. Kenya's Maternal Mortality Ratio (MMR) declined from 362 to 353 deaths per 100,000 live births between 2014 and 2021. However…

Intrapartum and postpartum antibiotic use in seven low‐ and middle‐income countries: Findings from the A‐PLUS trial Open

Sarah Saleem, Haleema Yasmin, Janet Moore, Anum Rahim, Iram Shakeel , et al. · 2024

Objective To describe the intrapartum and postpartum use of non‐study antibiotics in low‐ and middle‐income countries (LMICs) during the double‐blinded NICHD Global Network Azithromycin in Labor (A‐PLUS) trial. Design The antibiotic use su…

Improving health equity through sustained academic partnership: development of a maternal-fetal medicine fellowship training program in Western Kenya Open

David Nding'ori, Rachel F Spitzer, Julia Songok, Marie Buitendyk, Pallavi Mishra , et al. · 2024

Corrigendum to The impact of risk factors on aspirin's efficacy for the prevention of preterm birth. American Journal of Obstetrics & Gynecology MFM. Volume 5, Issue 10, October 2023, 101095 Open

Emily Nuss, Matthew Hoffman, Shivaprasad S. Goudar, Avinash Kavi, Mrityunjay Metgud , et al. · 2024

Maternal age extremes and adverse pregnancy outcomes in low-resourced settings Open

Paul Nyongesa, Osayame A. Ekhaguere, Irene Marete, Constance Tenge, Milsort Kemoi , et al. · 2023

Introduction Adolescent (<20 years) and advanced maternal age (>35 years) pregnancies carry adverse risks and warrant a critical review in low- and middle-income countries where the burden of adverse pregnancy outcomes is highest. Ob…

AJOG MFM Table of Contents Open

Annalise Penikis, Alice Zhou, Shelby R. Sferra, Abigail J. Engwall‐Gill, Jena L. Miller , et al. · 2023

“It’s complicated…”: Exploring second stage caesarean sections and reasons for non-performance of assisted vaginal births in Kenya: A mixed methods study Open

Fiona Dickinson, Helen Allott, Paul Nyongesa, Martin Eyinda, Onesmus M. Muchemi , et al. · 2023

Unnecessary Caesarean Section (CS) can have adverse effects on women and their newborns. Assisted vaginal birth/delivery (AVB/AVD) using a suction device or obstetric forceps is a potential alternative when delays or complications occur in…

The impact of risk factors on aspirin's efficacy for the prevention of preterm birth Open

Emily Nuss, Matthew Hoffman, Shivaprasad S. Goudar, Avinash Kavi, Mrityunjay Metgud , et al. · 2023

Prevention of maternal and neonatal death/infections with a single oral dose of azithromycin in women in labour in low-income and middle-income countries (A-PLUS): a study protocol for a multinational, randomised placebo-controlled clinical trial Open

Jennifer Hemingway‐Foday, Alan Tita, Elwyn Chomba, Musaku Mwenechanya, Trecious Mweemba , et al. · 2023

Introduction Maternal and neonatal infections are among the most frequent causes of maternal and neonatal mortality, and current antibiotic strategies have been ineffective in preventing many of these deaths. A randomised clinical trial co…

Birth weight and gestational age distributions in a rural Kenyan population Open

Sherri Bucher, Kayla J. Nowak, Kevin Otieno, Constance Tenge, Irene Marete , et al. · 2023

Cost-effectiveness of low-dose aspirin for the prevention of preterm birth: a prospective study of the Global Network for Women's and Children's Health Research Open

Jackie K. Patterson, Simon Neuwahl, Norman Goco, Janet Moore, Shivaprasad S. Goudar , et al. · 2023

Azithromycin to Prevent Sepsis or Death in Women Planning a Vaginal Birth Open

Alan Tita, Waldemar A. Carlo, Elizabeth M. McClure, Musaku Mwenechanya, Elwyn Chomba , et al. · 2023

Among women planning a vaginal delivery, a single oral dose of azithromycin resulted in a significantly lower risk of maternal sepsis or death than placebo but had little effect on newborn sepsis or death. (Funded by the Eunice Kennedy Shr…

It’s complicated…: Exploring the missed opportunities and reasons for non-performance of assisted vaginal births in Kenya Open

Fiona Dickinson, Helen Allott, Paul Nyongesa, Martin Eyinde, Onesmus M Muchemi , et al. · 2022

Unnecessary Caesarean Section (CS) can have adverse effects on women and their newborn. Assisted vaginal birth/delivery (AVB/AVD) using a suction device or obstetric forceps is a potential alternative when delays or complications occur in …

Birth weight and gestational age distributions in a rural Kenyan population Open

Sherri Bucher, Kayla J. Nowak, Kevin Otieno, Constance Tenge, Irene Marete , et al. · 2022

BackgroundWith the increased availability of access to prenatal ultrasound in low/middle-income countries, there is opportunity to better characterize the association between fetal growth and birth weight across global settings. This is im…

Maternal danger signs in pregnancy: adoption of a four-delay model in healthcare in Matayos subcounty, Busia, Kenya Open

Paul Nyongesa, Faith Yego, Philip Tonui, Benard Mwori Sorre, Omar Egessah · 2021

Background: Over 80 of maternal mortalities and % complications can be prevented if women recognize danger signs during pregnancy and promptly seek healthcare. Despite the timely recognition of maternal danger signs during pregnancy, delay…

Strengthening Weak Healthcare Systems for Maternal and Neonatal Care in Low and Middle Income Countries: The Missing Link Open

Paul Nyongesa, Faith Yego, Philiph Tonui, Peter Itsura, Bennad Sorre , et al. · 2021

Introduction: Preventable maternal and newborn mortalities still occur in local communities in Kenya since access to maternal and newborn healthcare services remains a big challenge. Barriers to access in resource-constrained settings have…

Safety of daily low-dose aspirin use during pregnancy in low-income and middle-income countries Open

Vanessa L. Short, Matthew Hoffman, Mrityunjay Metgud, Avinash Kavi, Shivaprasad S. Goudar , et al. · 2021

Regional trends in birth weight in low- and middle-income countries 2013–2018 Open

Irene Marete, Osayame A. Ekhaguere, Carla Bann, Sherri Bucher, Paul Nyongesa , et al. · 2020

Maternal mortality in six low and lower-middle income countries from 2010 to 2018: risk factors and trends Open

Melissa Bauserman, Vanessa Thorsten, Tracy L. Nolen, Jackie K. Patterson, Adrien Lokangaka , et al. · 2020

Evaluating the effect of care around labor and delivery practices on early neonatal mortality in the Global Network’s Maternal and Newborn Health Registry Open

Archana Patel, Elizabeth Simmons, Sowmya R. Rao, Janet Moore, Tracy L. Nolen , et al. · 2020

Background Neonatal deaths in first 28-days of life represent 47% of all deaths under the age of five years globally and are a focus of the United Nation’s (UN’s) Sustainable Development Goals. Pregnant women are delivering in facilities b…

Low-dose aspirin for the prevention of preterm delivery in nulliparous women with a singleton pregnancy (ASPIRIN): a randomised, double-blind, placebo-controlled trial Open

Matthew Hoffman, Shivaprasad S. Goudar, Bhalachandra S. Kodkany, Mrityunjay Metgud, Manjunath S. Somannavar , et al. · 2020

Contraceptive Use in Sub-Saharan Africa: The Sociocultural Context Open

Paul Nyongesa, Jack Odunga · 2015

Background: This paper presents information on needs, barriers, and approaches to access and use of contraception by adolescents in low and middle income countries (LMIC). Despite the various strategies and policies, total fertility rate …

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