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View article: High-flow nasal Oxygen with or without alternating helmet Non-invasive ventilation for Oxygenation sUpport in acute Respiratory failure (HONOUR): a protocol for a pilot randomised controlled trial
High-flow nasal Oxygen with or without alternating helmet Non-invasive ventilation for Oxygenation sUpport in acute Respiratory failure (HONOUR): a protocol for a pilot randomised controlled trial Open
Introduction Acute hypoxaemic respiratory failure is a common reason for intensive care unit (ICU) admission. Non-invasive respiratory support strategies such as high-flow nasal oxygen (HFNO) and helmet non-invasive ventilation may reduce …
View article: The Effects of an Exercise and Lifestyle Intervention Program on Cardiovascular, Metabolic Factors and Cognitive Performance in Middle-Aged Adults with Type II Diabetes: A Pilot Study
The Effects of an Exercise and Lifestyle Intervention Program on Cardiovascular, Metabolic Factors and Cognitive Performance in Middle-Aged Adults with Type II Diabetes: A Pilot Study Open
Background: Canada is experiencing a rise in type II diabetes mellitus (T2DM), a known risk factor for accelerated cognitive decline and dementia. Within the context of an aging population, this will impose significant individual and socie…
View article: Cardiovascular Prehabilitation in Patients Awaiting Heart Transplantation— Addressing Clinical Needs (the PREHAB HTx Study)
Cardiovascular Prehabilitation in Patients Awaiting Heart Transplantation— Addressing Clinical Needs (the PREHAB HTx Study) Open
NCT02957955.
View article: Rationale and protocol of the LEAD 2.0 study: a randomized controlled trial assessing the feasibility of a virtually delivered 6-month exercise and nutrition intervention in older adults with subjective cognitive decline (SCD)
Rationale and protocol of the LEAD 2.0 study: a randomized controlled trial assessing the feasibility of a virtually delivered 6-month exercise and nutrition intervention in older adults with subjective cognitive decline (SCD) Open
Background With growing prevalence of dementia worldwide, dementia risk reduction is a key interest of the World Health Organization’s Global Dementia Action Plan. Subjective cognitive decline (SCD) is a prominent predictor of future demen…
View article: A randomized controlled trial adding behavioral counseling to supervised physical activity in people living with and beyond cancer (BOOST-UP-): a study protocol for a live remotely-delivered behavior change intervention
A randomized controlled trial adding behavioral counseling to supervised physical activity in people living with and beyond cancer (BOOST-UP-): a study protocol for a live remotely-delivered behavior change intervention Open
Background For many people living with and beyond cancer (LWBC), physical activity (PA) declines significantly after supervised PA interventions. The effect of short-term, supervised PA interventions on motivational outcomes and longer-ter…
View article: MRS demonstrates elevated brain glutathione in vascular mild cognitive impairment compared to cognitively normal coronary artery disease controls
MRS demonstrates elevated brain glutathione in vascular mild cognitive impairment compared to cognitively normal coronary artery disease controls Open
INTRODUCTION Oxidative stress (OS) is implicated in dementia. While elevated peripheral OS biomarkers were observed in vascular mild cognitive impairment (vMCI), the role of central antioxidants remains unclear. We assessed levels of the m…
View article: Telephone coaching supports exercise in people with prediabetes and diabetes: A mixed-methods study
Telephone coaching supports exercise in people with prediabetes and diabetes: A mixed-methods study Open
Objective: To evaluate whether a telephone coaching intervention can help people with prediabetes and diabetes to exercise as recommended by diabetes guidelines after a lifestyle intervention. Methods: The telefone coaching intervention in…
View article: Characterizing health literacy in cardiac rehabilitation patients: a decade of multinational data (2014–2024)
Characterizing health literacy in cardiac rehabilitation patients: a decade of multinational data (2014–2024) Open
Background Cardiovascular disease (CVD) is a leading global health issue, with a high prevalence and significant economic impact. Cardiac rehabilitation (CR) can help mitigate this burden through its comprehensive approach, which includes,…
View article: The effects of reactive balance training on cardiorespiratory fitness and muscle strength: a pilot randomized controlled trial
The effects of reactive balance training on cardiorespiratory fitness and muscle strength: a pilot randomized controlled trial Open
Background Reactive balance training (RBT) may improve multiple components of physical fitness, including aerobic capacity and muscle strength. However, there have been no studies examining its effects on these factors in people with strok…
View article: Brain glutathione in vascular mild cognitive impairment and cognitive correlates
Brain glutathione in vascular mild cognitive impairment and cognitive correlates Open
Background Oxidative stress (OS) has been implicated in age‐related neurodegeneration and may be important in prodromal states such as vascular mild cognitive impairment (vMCI). Higher peripheral OS is reported in vMCI patients; however, t…
View article: Examining the relationship between angiopoietin‐2 and cognition in early Alzheimer’s disease
Examining the relationship between angiopoietin‐2 and cognition in early Alzheimer’s disease Open
Background Angiopoietin‐2, which regulates endothelial permeability and angiogenesis functions, is emerging as a potential biomarker for early Alzheimer’s disease (AD). Elevated levels of cerebrospinal fluid angiopoietin‐2 concentrations h…
View article: Lipid peroxidation in patients with vascular mild cognitive impairment from a memory and antioxidants in vascular impairment trial (MOVE‐IT)
Lipid peroxidation in patients with vascular mild cognitive impairment from a memory and antioxidants in vascular impairment trial (MOVE‐IT) Open
Background Oxidative stress (OS) has been a target of interest for vascular dementia, given its implications in pathogenesis. OS may be important in prodromal stage, such as vascular mild cognitive impairment (vMCI), and examining OS marke…
View article: Effects of an Exercise and Lifestyle Education Program in Brazilians living with prediabetes or diabetes: study protocol for a multicenter randomized controlled trial
Effects of an Exercise and Lifestyle Education Program in Brazilians living with prediabetes or diabetes: study protocol for a multicenter randomized controlled trial Open
Background Patient education is a crucial strategy for promoting prevention and diabetes self-management since glycemic control achievement involves taking medications, medical nutrition therapy, physical exercise, and behavior changes. Ho…
View article: A multi-site mixed-method evaluation of ‘Cardiac College for Women’ implementation: perspectives of cardiac rehabilitation patients and providers
A multi-site mixed-method evaluation of ‘Cardiac College for Women’ implementation: perspectives of cardiac rehabilitation patients and providers Open
A Cardiac College for Women curriculum was developed to address the dearth of women-focused cardiac rehabilitation (CR) education. This study investigated: (1) patient utilization of the education; (2) acceptability and applicability of th…
View article: Rationale and protocol of the LEAD 2.0 study: A randomized controlled trial assessing the feasibility of a virtually-delivered 6-month exercise and nutrition intervention in older adults with subjective cognitive decline (SCD)
Rationale and protocol of the LEAD 2.0 study: A randomized controlled trial assessing the feasibility of a virtually-delivered 6-month exercise and nutrition intervention in older adults with subjective cognitive decline (SCD) Open
Background With growing prevalence of dementia worldwide, dementia risk reduction is a key interest of the World Health Organization’s Global Dementia Action Plan. Subjective cognitive decline (SCD) is a prominent predictor of future demen…
View article: Transplantation, bridging, and support technologies in pulmonary hypertension
Transplantation, bridging, and support technologies in pulmonary hypertension Open
Despite the progress made in medical therapies for treating pulmonary hypertension (PH), a subset of patients remain susceptible to developing a maladaptive right ventricular phenotype. The effective management of end-stage PH presents sub…
View article: Cytochrome P450-soluble epoxide hydrolase oxylipins, depression and cognition in type 2 diabetes
Cytochrome P450-soluble epoxide hydrolase oxylipins, depression and cognition in type 2 diabetes Open
Associations of CYP450-sEH metabolites and depressive symptoms with cognition highlight the biomarker and therapeutic potential of the CYP450-sEH pathway in T2DM.
View article: Urinalysis is predictive for absence of urinary tract infection in men with and without catheters
Urinalysis is predictive for absence of urinary tract infection in men with and without catheters Open
Objectives To determine accuracy of negative urinalysis (UA) for predicting negative urine culture and the absence of urinary tract infection (UTI), and optimal urine culture growth cutoff for UTI diagnosis in men with and without urinary …
View article: Evidence-informed development of women-focused cardiac rehabilitation education
Evidence-informed development of women-focused cardiac rehabilitation education Open
Background Cardiovascular rehabilitation (CR) is an outpatient model of secondary preventive care proven to mitigate the burden of cardiovascular disease (CVD). Despite their differential risk factor burden, context and often different for…
View article: Neurofilament Light Chain as a Biomarker of Global Cognition in Individuals With Possible Vascular Mild Cognitive Impairment
Neurofilament Light Chain as a Biomarker of Global Cognition in Individuals With Possible Vascular Mild Cognitive Impairment Open
Background Neurofilament Light Chain (NfL) is a biomarker of axonal injury elevated in mild cognitive impairment (MCI) and Alzheimer’s disease dementia. Blood NfL also inversely correlates with cognitive performance in those conditions. Ho…
View article: Psychological stress across the lifespan and cognitive function among older adults: The moderating role of a healthy lifestyle
Psychological stress across the lifespan and cognitive function among older adults: The moderating role of a healthy lifestyle Open
Background: Canada is experiencing a rise in type II diabetes mellitus (T2DM), a known risk factor for accelerated cognitive decline and dementia. Within the context of an aging population, this will impose significant individual and socie…
View article: The Effects of an Exercise and Lifestyle Intervention Program on Cardiovascular, Metabolic Factors and Cognitive Performance in Middle-Aged Adults with Type II Diabetes: A Pilot Study
The Effects of an Exercise and Lifestyle Intervention Program on Cardiovascular, Metabolic Factors and Cognitive Performance in Middle-Aged Adults with Type II Diabetes: A Pilot Study Open
Background: Canada is experiencing a rise in type II diabetes mellitus (T2DM), a known risk factor for accelerated cognitive decline and dementia. Within the context of an aging population, this will impose significant individual and socie…
View article: The Effects of an Exercise and Lifestyle Intervention Program on Cardiovascular, Metabolic Factors and Cognitive Performance in Middle-Aged Adults with Type II Diabetes: A Pilot Study
The Effects of an Exercise and Lifestyle Intervention Program on Cardiovascular, Metabolic Factors and Cognitive Performance in Middle-Aged Adults with Type II Diabetes: A Pilot Study Open
Background: Canada is experiencing a rise in type II diabetes mellitus (T2DM), a known risk factor for accelerated cognitive decline and dementia. Within the context of an aging population, this will impose significant individual and socie…
View article: Increasing Health Behaviors and Psychological Measures with an Adapted Version of the ACCELERATION Program
Increasing Health Behaviors and Psychological Measures with an Adapted Version of the ACCELERATION Program Open
Background Recent evidence highlights the importance of interventions tackling physical inactivity and unhealthy eating in lower-income countries. The purpose of this study was to examine the effectiveness of the Canadian ACCELERATION life…
View article: Effects of a comprehensive structured patient education intervention on disease-related knowledge and behaviour change among people living with type 2 diabetes in the Philippines
Effects of a comprehensive structured patient education intervention on disease-related knowledge and behaviour change among people living with type 2 diabetes in the Philippines Open
Introduction Addressing the ongoing needs of individuals with diabetes, particularly in low- and middle-income countries like the Philippines, requires a focus on regular follow-ups with healthcare teams, adherence to healthy behaviors, an…
View article: Evaluation of a digital patient education programme for Chinese immigrants after a heart attack
Evaluation of a digital patient education programme for Chinese immigrants after a heart attack Open
Aims To evaluate a self-administered digital education resource for patients after a heart attack (adapted simplified Chinese version of Cardiac College™) on secondary prevention knowledge and health behaviour change outcomes. Methods and …