Paul O’Hare
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View article: Serial measurement of nitrite and xanthine oxidase (XO) to assess antimicrobial pharmacodynamics (PD) and treatment efficacy in urinary tract infections (UTIs): A proof-of-concept for personalized antimicrobial therapy
Serial measurement of nitrite and xanthine oxidase (XO) to assess antimicrobial pharmacodynamics (PD) and treatment efficacy in urinary tract infections (UTIs): A proof-of-concept for personalized antimicrobial therapy Open
Introduction: UTI is a common indication for antimicrobial therapy. Biomarkers specific to the causative organism, such as nitrite, are often employed in UTI diagnosis through qualitative detection methods such as dipsticks. XO was found t…
View article: Legacy benefits of blood pressure treatment on cardiovascular events are primarily mediated by improved blood pressure variability: the ASCOT trial
Legacy benefits of blood pressure treatment on cardiovascular events are primarily mediated by improved blood pressure variability: the ASCOT trial Open
Background and Aims Visit-to-visit systolic blood pressure variability (BPV) is an important predictor of cardiovascular (CV) outcomes. The long-term effect of a period of blood pressure (BP) control, but with differential BPV, is uncertai…
View article: An eye opener: improving attendance rates of retinopathy screening within the paediatric diabetes clinic
An eye opener: improving attendance rates of retinopathy screening within the paediatric diabetes clinic Open
Aims: To audit eye screening attendance rates in children pre and post implementation of a screening service offered on the same day as their diabetes clinic appointment and to identify characteristics of non‐attenders. Methods: Data were …
View article: The <scp>DAPA‐DIET</scp> study: Metabolic response to Dapagliflozin combined with dietary carbohydrate restriction in patients with Type 2 Diabetes Mellitus and Obesity—A longitudinal cohort study
The <span>DAPA‐DIET</span> study: Metabolic response to Dapagliflozin combined with dietary carbohydrate restriction in patients with Type 2 Diabetes Mellitus and Obesity—A longitudinal cohort study Open
Objective The cardio‐renal benefits of sodium glucose‐like transporter 2 inhibitor (SGLT2i) therapies have been demonstrated in patients with and without type 2 diabetes. However, no studies have explored the long‐term metabolic effects of…
View article: Insights into optimising education for patients living with diabetes mellitus: A model for the post‐pandemic era, informed by survey data
Insights into optimising education for patients living with diabetes mellitus: A model for the post‐pandemic era, informed by survey data Open
Background Patient education represents the key element in the management of diabetes mellitus (DM) and has changed dramatically during the last 3 years. Uptake of structured education is poor, and patient perception of received education …
View article: Novel perspectives of sodium handling in type 2 diabetes mellitus
Novel perspectives of sodium handling in type 2 diabetes mellitus Open
Future studies should focus on novel therapeutic opportunities for sodium regulation in T2D and other conditions of sodium dysregulation. The ratio of free:bound dermal sodium (reflecting sodium storage capacity) could be utilized as a cli…
View article: Body composition in heart failure and the impact of cardiac resynchronisation therapy: a proof-of-concept study
Body composition in heart failure and the impact of cardiac resynchronisation therapy: a proof-of-concept study Open
Aims Body composition (BC) is known to alter in heart failure. Cardiac resynchronisation therapy (CRT) improves left ventricular geometry but the impact on BC is unknown. Our aim was to evaluate BC in these patients before and after CRT im…
View article: Characterisation of circulating biomarkers before and after cardiac resynchronisation therapy and their role in predicting CRT response: the COVERT-HF study
Characterisation of circulating biomarkers before and after cardiac resynchronisation therapy and their role in predicting CRT response: the COVERT-HF study Open
Aims Cardiac resynchronisation therapy (CRT) is effective treatment for selected patients with heart failure (HF) but has ~30% non-response rate. We evaluated whether specific biomarkers can predict outcome. Methods A prospective single-ce…
View article: Extracellular cardiac matrix biomarkers in patients with reduced ejection fraction heart failure as predictors of response to cardiac resynchronisation therapy: a systematic review
Extracellular cardiac matrix biomarkers in patients with reduced ejection fraction heart failure as predictors of response to cardiac resynchronisation therapy: a systematic review Open
Objective Cardiac resynchronisation therapy (CRT) is an effective therapy for selected patients with heart failure (HF); however, a significant non-response rate exists. We examined current evidence on extracellular cardiac matrix (ECM) bi…
View article: 55 Evaluation of Potential Clinical Response and Cardiovascular Outcomes Predictors in a Tertiary Cardiac Resynchronisation Therapy Implantation Centre
55 Evaluation of Potential Clinical Response and Cardiovascular Outcomes Predictors in a Tertiary Cardiac Resynchronisation Therapy Implantation Centre Open
Background Cardiac Resynchronisation Therapy (CRT) is an effective treatment for dys-synchronous chronic heart failure (CHF), however there is a significant non-response rate. Clinic predictors of response and cardiovascular outcome are of…