Explanipedia

Correction: Nutritional markers and proteome in patients undergoing treatment for pulmonary tuberculosis differ by geographic region Open

Leah G. Jarlsberg, Komal Kedia, Jason Wendler, Aaron Wright, Paul Piehowski , et al. · 2025

[This corrects the article DOI: 10.1371/journal.pone.0250586.].

spammR: an R package designed for analysis and integration of spatial multi-omic measurements Open

Yannick Mahlich, Harkirat Sohi, Paul Piehowski, Jason McDermott, Sara J.C. Gosline · 2025

Summary Spatial omics is a young and evolving field and as such shows rapid development of novel technologies and analysis methods to measure transcripts, proteins, metabolites, and post-translational modifications at high spatial resoluti…

Subcutaneous adipose tissue-secreted proteins as endocrine regulators of physical and cognitive function in older adults Open

Cheehoon Ahn, Ian Tamburini, James Sanford, Mingqi Zhou, Farah Gamie , et al. · 2025

Declines in skeletal muscle and cognitive function in older adults have been linked to abnormalities in abdominal subcutaneous adipose tissue (ASAT), yet the underlying molecular mediators remain poorly understood. Here, leveraging ASAT tr…

Integrated lipidomic and proteomic profiling reveals metabolic network disruption by SARS-CoV-2 variants Open

Scotland Farley, Jennifer Kyle, Helene Jahn, Lisa Bramer, Paul Piehowski , et al. · 2025

The rapid evolution of SARS-CoV-2 has produced myriad viral strains with increasing transmissibility and capacity for immune evasion. While effective vaccination campaigns have reduced the fatalities associated with SARS-CoV-2, infections …

Multi-Omic Profiling Identifies Conserved Metabolic Pathways Critical for SARS-CoV-2 Variants Infection Open

Scotland Farley, Jennifer Kyle, Helene Jahn, Lisa Bramer, Paul Piehowski , et al. · 2025

The rapid evolution of SARS-CoV-2 has led to the emergence of numerous variants with en-hanced transmissibility and immune evasion. Despite widespread vaccination, infections persist, and the mechanisms by which SARS-CoV-2 reprograms host …

Subcutaneous Adipose Tissue-Secreted Proteins as Endocrine Regulators of Physical and Cognitive Function in Older Adults Open

Lauren M. Sparks, Cheehoon Ahn, Ian Tamburini, James Sanford, Mingqi Zhou , et al. · 2025

Increased inflammation as well as decreased endoplasmic reticulum stress and translation differentiate pancreatic islets from donors with pre-symptomatic stage 1 type 1 diabetes and non-diabetic donors Open

Adam Swensen, Paul Piehowski, Jing Chen, X’avia Y. Chan, Shane S. Kelly , et al. · 2025

The LC-MS raw datasets that support the findings of this study have been deposited in the online repository: MassIVE ( https://massive.ucsd.edu/ProteoSAFe/static/massive.jsp ) with accession no. MSV000090212.

Data for EMSL Project 60257 from April 2024 Open