Pranab Kumar Paul
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View article: Maintenance of proteostasis by Drosophila Rer1 is essential for competitive cell survival and Myc-driven overgrowth
Maintenance of proteostasis by Drosophila Rer1 is essential for competitive cell survival and Myc-driven overgrowth Open
Defects in protein homeostasis can induce proteotoxic stress, affecting cellular fitness and, consequently, overall tissue health. In various growing tissues, cell competition based mechanisms facilitate detection and elimination of these …
View article: Loss of Rer1 causes proteotoxic stress that drives cell competition and inhibits Myc-driven overgrowth
Loss of Rer1 causes proteotoxic stress that drives cell competition and inhibits Myc-driven overgrowth Open
Cell competition is a developmental phenomenon that allows the selection of healthier cells in a developing tissue. In this process, cells with reduced fitness, conceivably due to harmful mutations, acquire the ‘loser’ status and are elimi…