Explanipedia

Possible clearance of transfusion-acquired nef/LTR-deleted attenuated HIV-1 infection by an elite controller with CCR5 Δ32 heterozygous and HLA-B57 genotype Open

John Zaunders, Wayne B. Dyer, Melissa J. Churchill, C. Mee Ling Munier, Philip Cunningham , et al. · 2024

Background: Subject C135 is one of the members of the Sydney Blood Bank Cohort, infected in 1981 through transfusion with attenuated nef/3′ long terminal repeat (LTR)-deleted HIV-1, and has maintained undetectable plasma viral load and ste…

HIV transcription persists in the brain of virally suppressed people with HIV Open

Janna Jamal Eddine, Thomas A. Angelovich, Jingling Zhou, Sarah J. Byrnes, Carolin Tumpach , et al. · 2024

HIV persistence in the brain is a barrier to cure, and potentially contributes to HIV-associated neurocognitive disorders. Whether HIV transcription persists in the brain despite viral suppression with antiretroviral therapy (ART) and is s…

Nanocapsules Comprised of Purified Protein: Construction and Applications in Vaccine Research Open

Ivana Skakic, Aya C. Taki, Jasmine E. Francis, Chaitali Dekiwadia, Thi Thu Hao Van , et al. · 2024

Nanoparticles show great promise as a platform for developing vaccines for the prevention of infectious disease. We have been investigating a method whereby nanocapsules can be formulated from protein, such that the final capsules contain …

Regional Analysis of Intact and Defective HIV Proviruses in the Brain of Viremic and Virally Suppressed People with HIV Open

Thomas A. Angelovich, Catherine R. Cochrane, Jingling Zhou, Carolin Tumpach, Sarah J. Byrnes , et al. · 2023

Here, we provide the first regional analysis of intact and defective HIV reservoirs within the brain. Brain tissue from both viremic and virally suppressed people with HIV (PWH) harbored HIV pol DNA in all regions tested, with lower levels…

Persistence of envelopes in different CD4+ T-cell subsets in antiretroviral therapy-suppressed people with HIV Open

Matthew J. Gartner, Carolin Tumpach, Ashanti Dantanarayana, Jared Stern, Jennifer M. Zerbato , et al. · 2022

Objectives: Despite suppressive antiretroviral therapy (ART), HIV can persist in a diverse range of CD4 + T-cell subsets. Through longitudinal env sampling from people with HIV (PWH) on ART, we characterized the persistence and phenotypic …

Issue Information Open

Daniel Pastula, Kenneth L. Tyler, Catherine R. Cochrane, Thomas A. Angelovich, Sarah J. Byrnes , et al. · 2022

Wiley is a founding member of the UN-backed HINARI, AGORA, and OARE initiatives.They are now collectively known as Research4Life, making online scientific content available free or at nominal cost to researchers in developing countries.

Intact HIV Proviruses Persist in the Brain Despite Viral Suppression with ART Open

Catherine R. Cochrane, Thomas A. Angelovich, Sarah J. Byrnes, Emily Waring, Aleks C. Guanizo , et al. · 2022

Objective Human immunodeficiency virus (HIV) persistence in blood and tissue reservoirs, including the brain, is a major barrier to HIV cure and possible cause of comorbid disease. However, the size and replication competent nature of the …

Modular Lentiviral Vectors for Highly Efficient Transgene Expression in Resting Immune Cells Open

Christina Fichter, Anupriya Aggarwal, Andrew Kam Ho Wong, Samantha McAllery, Vennila Mathivanan , et al. · 2021

Gene/cell therapies are promising strategies for the many presently incurable diseases. A key step in this process is the efficient delivery of genes and gene-editing enzymes to many cell types that may be resistant to lentiviral vector tr…

Potential Impact of Human Cytomegalovirus Infection on Immunity to Ovarian Tumours and Cancer Progression Open

Momodou Cox, Apriliana E. R. Kartikasari, Paul R. Gorry, Katie L. Flanagan, Magdalena Plebanski · 2021

Ovarian cancer (OC) is one of the most common, and life-threatening gynaecological cancer affecting females. Almost 75% of all OC cases are diagnosed at late stages, where the 5-year survival rate is less than 30%. The aetiology of the dis…

Longitudinal analysis of subtype C envelope tropism for memory CD4+ T cell subsets over the first 3 years of untreated HIV-1 infection Open

Matthew J. Gartner, Paul R. Gorry, Carolin Tumpach, Jingling Zhou, Ashanti Dantanarayana , et al. · 2020

Professor Mark Wainberg Open

Monsef Benkirane, Ben Berkhout, Persephone Borrow, Ariberto Fassati, Masahiro Fujii , et al. · 2020

When Kuan-Teh Jeang (‘Teh’ to everyone) made the bold and prescient decision to join the earliest wave of pure online academic publishing and founded the journal Retrovirology, Mark Wainberg was one of the simplest and most obvious choices…

Understanding the mechanisms driving the spread of subtype C HIV-1 Open

Matthew J. Gartner, Michael Roche, Melissa J. Churchill, Paul R. Gorry, Jacqueline K. Flynn · 2020

Human immunodeficiency virus type 1 (HIV-1) subtype C (C-HIV) is the most prevalent form of HIV-1 globally, accounting for approximately 50% of infections worldwide. C-HIV is the predominant and near-exclusive subtype in the low resource r…

CXCR4-Using HIV Strains Predominate in Naive and Central Memory CD4 <sup>+</sup> T Cells in People Living with HIV on Antiretroviral Therapy: Implications for How Latency Is Established and Maintained Open

Michael Roche, Carolin Tumpach, Jori Symons, Matthew J. Gartner, Jenny L. Anderson , et al. · 2019

In people living with HIV (PLWH) on suppressive ART, latent HIV can be found in a diverse range of CD4 + T cells, including quiescent naive and central memory cells that are typically difficult to infect in vitro . It is currently unclear …

Whole Transcriptome Analysis of Aedes albopictus Mosquito Head and Thorax Post-Chikungunya Virus Infection Open

Ravikiran Vedururu, Matthew J. Neave, Vinod Sundaramoorthy, Diane Green, Jennifer Harper , et al. · 2019

Chikungunya virus (CHIKV) is transmitted by Aedes mosquitoes and causes prolonged arthralgia in patients. After crossing the mosquito midgut barrier, the virus disseminates to tissues including the head and salivary glands. To better under…

RNASeq Analysis of Aedes albopictus Mosquito Midguts after Chikungunya Virus Infection Open

Ravikiran Vedururu, Matthew J. Neave, Mary Tachedjian, Melissa J. Klein, Paul R. Gorry , et al. · 2019

Chikungunya virus (CHIKV) is an emerging pathogen around the world and causes significant morbidity in patients. A single amino acid mutation in the envelope protein of CHIKV has led to a shift in vector preference towards Aedes albopictus…

Possible clearance of transfusion-acquired nef/LTR-deleted attenuated HIV-1 infection by an elite controller with CCR5 Δ32 heterozygous and HLA-B57 genotype Open

John Zaunders, Wayne B. Dyer, Melissa J. Churchill, C. Mee Ling Munier, Philip Cunningham , et al. · 2019

Subject C135's early PCR and weak antibody results are consistent with limited infection with a poorly replicating nef/LTR-deleted strain of HIV-1. With his HLA-B57-restricted gag-specific CD8 and helper HLA-DR13-restricted CD4 T ce…

Low levels of HIV-1 envelope-mediated fusion are associated with long-term survival of an infected CCR5−/− patient Open

Paul R. Gorry, Fahim Ahmad, Jonathon E. Mohl, Ghalib Alkhatib · 2018

Env sequence polymorphisms identified two distinct fusion phenotypes isolated from infected CCR5-/- patients. Swapping experiments confirmed DR's low fusion phenotype. Env-mediated fusion is a critical factor among others contributing to l…

RNASeq analysis of<i>Aedes albopictus</i>mosquitoes during chikungunya virus infection Open

Ravikiran Vedururu, Matthew J. Neave, Mary Tachedjian, Paul R. Gorry, Jean‐Bernard Duchemin , et al. · 2018

Chikungunya virus (CHIKV), preferentially transmitted by Aedes mosquitoes, is an emerging pathogen around the world and causes significant morbidity in patients. A single amino acid mutation in the envelope protein of CHIKV has led to shif…

31 High prevalence of CXCR4-using virus and low clonal expansion in infected naïve and central memory CD4+ T cells in individuals on ART Open

Michael Roche, Carolin Tumpach, Jori Symons, Paul Cameron, Melissa J. Churchill , et al. · 2017

Professor Mark Wainberg Open

Monsef Benkirane, Ben Berkhout, Persephone Borrow, Ariberto Fassati, Masahiro Fujii , et al. · 2017

When Kuan-Teh Jeang (‘Teh’ to everyone) made the bold and prescient decision to join the earliest wave of pure online academic publishing and founded the journal Retrovirology, Mark Wainberg was one of the simplest and most obvious choices…

HIV-1 and SIV Predominantly Use CCR5 Expressed on a Precursor Population to Establish Infection in T Follicular Helper Cells Open

Yin Xu, Chansavath Phetsouphanh, Kazuo Suzuki, Anu Aggrawal, Stéphanie Graff‐Dubois , et al. · 2017

The major route of infection of Tfh in macaques and humans appears to be via a CCR5-expressing pre-Tfh population. As the generation of Tfh are important for establishing effective immune responses during primary infections, Tfh are…

Frequency and Env determinants of HIV-1 subtype C strains from antiretroviral therapy-naive subjects that display incomplete inhibition by maraviroc Open

Katharina Borm, Martin R. Jakobsen, Kieran Cashin, Jacqueline K. Flynn, Paula Ellenberg , et al. · 2016

Author Index Open

Mikael Akke, Norma Allewell, An Xiaomeng, Antony Jisha, B Bakaletz , et al. · 2016

Genotypic Prediction of Co-receptor Tropism of HIV-1 Subtypes A and C Open

Mona Riemenschneider, Kieran Cashin, Bettina Budeus, Saleta Sierra, Elham Shirvani‐Dastgerdi , et al. · 2016

i-bodies, Human Single Domain Antibodies That Antagonize Chemokine Receptor CXCR4 Open

Katherine Griffiths, Olan Dolezal, Benjamin Cao, Susan K. Nilsson, Heng B. See , et al. · 2016

CXCR4 is a G protein-coupled receptor with excellent potential as a therapeutic target for a range of clinical conditions, including stem cell mobilization, cancer prognosis and treatment, fibrosis therapy, and HIV infection. We report her…

Molecular Gymnastics: Mechanisms of HIV-1 Resistance to CCR5 Antagonists and Impact on Virus Phenotypes Open

Michael Roche, Katharina Borm, Jacqueline K. Flynn, Sharon R. Lewin, Melissa J. Churchill , et al. · 2015

Human immunodeficiency virus type 1 (HIV-1) enters host cells through the binding of its envelope glycoproteins (Env) to the host cell receptor CD4 and then subsequent binding to a chemokine coreceptor, either CCR5 or CXCR4. CCR5 antagonis…

CNS-specific regulatory elements in brain-derived HIV-1 strains affect responses to latency-reversing agents with implications for cure strategies Open

Lachlan Gray, Daniel Cowley, Casey Welsh, Hao Lu, Bruce J. Brew , et al. · 2015

Inhibition of catechol-O-methyl transferase (COMT) by tolcapone restores reductions in microtubule-associated protein 2 (MAP2) and synaptophysin (SYP) following exposure of neuronal cells to neurotropic HIV Open

Ting Ting Lee, Gursharan Chana, Paul R. Gorry, Anne Ellett, Chad Bousman , et al. · 2015

Reliable Genotypic Tropism Tests for the Major HIV-1 Subtypes Open

Kieran Cashin, Lachlan Gray, Katherine Harvey, Danielle Perez-Bercoff, Guinevere Q. Lee , et al. · 2015

Paul R. Gorry YOU? Author Swipe