R.V. Paul Chan
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View article: Preface: Global Health Security in Vision Care: Addressing Disparities, Outbreaks, and Conflict
Preface: Global Health Security in Vision Care: Addressing Disparities, Outbreaks, and Conflict Open
Global public health security encompasses activities that are required, “both proactive and reactive,” to minimize the danger and impact of acute public health events that endanger people’s health across geographical regions and internatio…
View article: Balancing efficacy and patients experience: A cautious perspective on simulated daylight <scp>PDT</scp> for superficial <scp>BCC</scp>
Balancing efficacy and patients experience: A cautious perspective on simulated daylight <span>PDT</span> for superficial <span>BCC</span> Open
View article: Proliferative diabetic retinopathy subtypes defined by immune defense and endothelial mitochondrial dysfunction
Proliferative diabetic retinopathy subtypes defined by immune defense and endothelial mitochondrial dysfunction Open
View article: Impact of El Nino Southern Oscillation and Climate Change on Infectious Diseases with Ophthalmic Manifestations
Impact of El Nino Southern Oscillation and Climate Change on Infectious Diseases with Ophthalmic Manifestations Open
Climate change and the El Niño Southern Oscillation (ENSO) events have been increasingly linked to infectious disease outbreaks. While growing evidence has connected climate variability with systemic illnesses, the ocular implications rema…
View article: Deep learning-based prediction of cardiopulmonary disease in retinal images of premature infants
Deep learning-based prediction of cardiopulmonary disease in retinal images of premature infants Open
Importance Bronchopulmonary dysplasia (BPD) and pulmonary hypertension (PH) are leading causes of morbidity and mortality in premature infants. Objective To determine whether images obtained as part of retinopathy of prematurity (ROP) scre…
View article: Hydrogel-Based Vitreous Substitutes
Hydrogel-Based Vitreous Substitutes Open
Hydrogel-based vitreous substitutes have been considered as a potential solution for the treatment of retinal disorders, especially when the natural vitreous body is damaged due to trauma, disease, or surgery. With their high-water content…
View article: Glorbit: A Modular, Web-Based Platform for AI Based Periorbital Measurement in Low-Resource Settings
Glorbit: A Modular, Web-Based Platform for AI Based Periorbital Measurement in Low-Resource Settings Open
Periorbital measurements such as margin reflex distances (MRD1/2), palpebral fissure height, and scleral show are essential in diagnosing and managing conditions like ptosis and eyelid disorders. We developed Glorbit, a lightweight, browse…
View article: Glorbit: A Modular, Web-Based Platform for AI Based Periorbital Measurement in Low-Resource Settings (Preprint)
Glorbit: A Modular, Web-Based Platform for AI Based Periorbital Measurement in Low-Resource Settings (Preprint) Open
BACKGROUND Periorbital measurements such as margin reflex distances (MRD1/2), palpebral fissure height, and scleral show are critical in diagnosing and managing conditions like ptosis and disorders of the eyelid. OBJECTIVE We developed …
View article: The Influence of Ultra-Widefield Fluorescein Angiography on the Diagnosis and Management of Diabetic Retinopathy
The Influence of Ultra-Widefield Fluorescein Angiography on the Diagnosis and Management of Diabetic Retinopathy Open
Purpose: To study the influence of ultra-widefield fluorescein angiography (FA) on the diagnosis and management of diabetic retinopathy (DR). Methods: Ten experts in DR completed an online survey in which they were asked to diagnose and ma…
View article: 0400 Increased risk of dermatological immune-related adverse events in cancer patients treated with immune checkpoint inhibitors
0400 Increased risk of dermatological immune-related adverse events in cancer patients treated with immune checkpoint inhibitors Open
View article: 0413 IL-17 Inhibitors vs. methotrexate in preventing new-onset psoriatic arthritis in psoriasis patients: a retrospective population-level analysis
0413 IL-17 Inhibitors vs. methotrexate in preventing new-onset psoriatic arthritis in psoriasis patients: a retrospective population-level analysis Open
View article: Robust Uncertainty-Informed Glaucoma Classification Under Data Shift
Robust Uncertainty-Informed Glaucoma Classification Under Data Shift Open
This study introduces a tunable framework that explores the trade-off between prediction accuracy and data retention in glaucoma prediction. By managing uncertainty in model outputs, the approach lays a foundation for future decision suppo…
View article: <scp>AI</scp> sea ice forecasts for Arctic conservation: A case study predicting the timing of caribou sea ice migrations
<span>AI</span> sea ice forecasts for Arctic conservation: A case study predicting the timing of caribou sea ice migrations Open
Every autumn on the south coast of Victoria Island (Nunavut, Canada), endangered Dolphin and Union (DU) caribou ( Rangifer tarandus groenlandicus x pearyi ) wait for sea ice to form before continuing their southwards migration to the mainl…
View article: Coats disease presenting with vitreous hemorrhage and neovascular glaucoma
Coats disease presenting with vitreous hemorrhage and neovascular glaucoma Open
We report a patient with a unique presentation of advanced Coats disease. By highlighting the treatment approach and potential factors that led to the preservation of visual function, we hope to expand the literature on the diagnosis and m…
View article: Utility of ChatGPT and Large Language Models in Enhancing Patient Understanding of Urological Conditions
Utility of ChatGPT and Large Language Models in Enhancing Patient Understanding of Urological Conditions Open
Objectives: Large language models such as ChatGPT have been used to generate text in a conversational manner, and may be of use in providing patient information in a urological setting. This study evaluated the accuracy, presence of omissi…
View article: Cutaneous Dermatologic Manifestations of Cardiovascular Diseases: A Narrative Review
Cutaneous Dermatologic Manifestations of Cardiovascular Diseases: A Narrative Review Open
View article: An international survey on retinopathy of prematurity practice patterns during the COVID-19 pandemic and lessons for future management
An international survey on retinopathy of prematurity practice patterns during the COVID-19 pandemic and lessons for future management Open
View article: Affordable ultra-widefield smartphone PedCam for comprehensive pediatric retinal examination
Affordable ultra-widefield smartphone PedCam for comprehensive pediatric retinal examination Open
Widefield fundus photography is critical for the detection, documentation, and management of pediatric eye diseases. Existing clinical pediatric fundus cameras offer a limited field of view (FOV) and suboptimal image contrast, hindering co…
View article: Serial OCT Imaging of Spontaneous Closure of a Pediatric Traumatic Macular Hole
Serial OCT Imaging of Spontaneous Closure of a Pediatric Traumatic Macular Hole Open
Purpose: To describe a case of spontaneous closure of a pediatric traumatic macular hole (MH) using serial optical coherence tomography (OCT) imaging. Methods: A single case was evaluated. Results: An 8-year-old girl developed a full-thick…
View article: Affordable ultra-widefield smartphone PedCam for comprehensive pediatric retinal examination
Affordable ultra-widefield smartphone PedCam for comprehensive pediatric retinal examination Open
Widefield fundus photography is critical for the detection, documentation, and management of pediatric eye diseases. Existing clinical pediatric fundus cameras offer a limited field of view (FOV) and suboptimal image contrast, hindering co…
View article: Assessing spectral effectiveness in color fundus photography for deep learning classification of retinopathy of prematurity
Assessing spectral effectiveness in color fundus photography for deep learning classification of retinopathy of prematurity Open
This study reveals that the classification of ROP stages can be effectively achieved using either the green or red image alone. This finding enables the exclusion of blue images, acknowledged for their increased susceptibility to light tox…
View article: P Score: A Reference Image-Based Clinical Grading Scale for Vascular Change in Retinopathy of Prematurity
P Score: A Reference Image-Based Clinical Grading Scale for Vascular Change in Retinopathy of Prematurity Open
View article: Eye Care in Federally Qualified Health Centers
Eye Care in Federally Qualified Health Centers Open
View article: Aggressive Onset of a Progressive FEVR Phenotype in a Child With Novel Mutations in <i>LRP5</i> and <i>TSPAN12</i>
Aggressive Onset of a Progressive FEVR Phenotype in a Child With Novel Mutations in <i>LRP5</i> and <i>TSPAN12</i> Open
Purpose: To describe a patient with familial exudative vitreoretinopathy (FEVR) and the treatment course. Methods: A case was evaluated. Results: A 3-year-old boy presented with severe onset of FEVR, with a subhyaloid hemorrhage in 1 eye a…
View article: Multinational External Validation of Autonomous Retinopathy of Prematurity Screening
Multinational External Validation of Autonomous Retinopathy of Prematurity Screening Open
Importance Retinopathy of prematurity (ROP) is a leading cause of blindness in children, with significant disparities in outcomes between high-income and low-income countries, due in part to insufficient access to ROP screening. Objective …
View article: Childhood vision impairment and blindness in West Africa: public health measures and implications for systemic health
Childhood vision impairment and blindness in West Africa: public health measures and implications for systemic health Open
Childhood blindness is an issue of global health impact, affecting approximately 2 million children worldwide. Vision 2020 and the United Nations Sustainable Development Goals previously identified childhood blindness as a key issue in the…
View article: Genome-wide association identifies novel ROP risk loci in a multiethnic cohort
Genome-wide association identifies novel ROP risk loci in a multiethnic cohort Open
We conducted a genome-wide association study (GWAS) in a multiethnic cohort of 920 at-risk infants for retinopathy of prematurity (ROP), a major cause of childhood blindness, identifying 1 locus at genome-wide significance level (p < 5×10 …
View article: Assessing Spectral Effectiveness in Color Fundus Photography for Deep Learning Classification of Retinopathy of Prematurity
Assessing Spectral Effectiveness in Color Fundus Photography for Deep Learning Classification of Retinopathy of Prematurity Open
The purpose of this study is to investigate spectral effectiveness, i.e., the effects of color channels, in fundus photography on deep learning classification of retinopathy of prematurity (ROP). A convolutional neural network (CNN) end-to…
View article: Assessing Spectral Effectiveness in Color Fundus Photography for Deep Learning Classification of Retinopathy of Prematurity
Assessing Spectral Effectiveness in Color Fundus Photography for Deep Learning Classification of Retinopathy of Prematurity Open
The purpose of this study is to investigate spectral effectiveness, i.e., the effects of color channels, in fundus photography on deep learning classification of retinopathy of prematurity (ROP). A convolutional neural network (CNN) end-to…
View article: Validating the Generalizability of Ophthalmic Artificial Intelligence Models on Real-World Clinical Data
Validating the Generalizability of Ophthalmic Artificial Intelligence Models on Real-World Clinical Data Open
RWD is a potential solution for improving generalizability of DL models and enabling clinical translations in the care of prevalent blinding ophthalmic conditions, such as glaucoma.