Explanipedia

T48. PARENTS' PSYCHOSOCIAL EXPERIENCES LEARNING ABOUT THEIR INFANTS' GENETIC RISK OF AUTISM AND RELATED DISORDERS Open

Matthew S. Lebowitz, Renald Dambreville, Rebecca S. Siegel, Melanie M. Wall, Jeremy Veenstra‐VanderWeele , et al. · 2025

Distributive justice, diversity, and inclusion in precision medicine: what will success look like? Open

Elizabeth Cohn, Gail E. Henderson, Paul S. Appelbaum · 2025

Development and validation of the CAT-AD: a competence assessment tool for advance directives Open

Gregor Lindl, Jonas Karneboge, Paul S. Appelbaum, Tanja R. Müller, Daniel Garmann , et al. · 2025

Background This study aimed to validate the Competence Assessment Tool for Advance Directives (CAT-AD), designed to support the assessment and clinical judgment of an individual’s competence to complete an advance directive, particularly i…

Understanding Violent Behavior in Early Psychosis Through the Fluid Vulnerability Theory: an Exploratory Qualitative Study Open

Stephanie A. Rolin, Megan G. Flores, Deirdre Caffrey, Jennifer Mootz, Lisa B. Dixon , et al. · 2025

Compared to the general population, young adults with early psychosis are at increased risk of violent behavior. Existing research has found contextual similarities between violent behavior and suicidal behavior. Therefore, this study exam…

Ethical considerations of deep brain stimulation for treatment refractory schizophrenia: surveying stakeholders Open

Judith Gault, Nicola G. Cascella, Nidal Moukaddam, Seppo Lehto, Patrick Hosokawa , et al. · 2025

Introduction Ethical concerns have been raised by both current and historically controversial neurosurgical interventions for treatment-refractory schizophrenia and schizoaffective disorder (TR-SZ). Considering advances in next-generation …

Imputing Parental Genotypes through Mendelian Imputation: Ethical and Legal Considerations Open

Margot P. van de Weijer, Emily Bassett, Paul S. Appelbaum, Evan J. Giangrande, Lucas J. Matthews · 2025

Mendelian imputation is a promising method for imputing missing parental genotypes and estimating direct genetic effects. While the method has clear scientific benefits, so far there has been little reflection on its legal and ethical impl…

Systematic Review: The Psychosocial Impacts of Autism-Related Genetic Testing Open

Betty Shuc Han Wills, Margaret M. Matthews, Josephine Johnston, Isabel Bolo, Ruth Ottman , et al. · 2025

An analysis of firearm legality and lethality in 625 U.S.‐based mass murders involving firearms Open

R. Tyler Rogers, Hannah Hesson, Sloan E. Bergstresser, Paul S. Appelbaum, Gary Brucato , et al. · 2025

Understanding the relationship between firearm regulations and the lethality of mass murder involving firearms has implications for prevention efforts. We examined 625 incidents of mass murder involving firearms that occurred in the United…

Cannabis involvement and mass shooting events in the United States from 1900 to 2019 Open

Ragy R. Girgis, Hannah Hesson, Paul S. Appelbaum, Gary Brucato · 2025

Cannabis use may be harmful in subgroups of individuals (eg, those who committed mass shootings) who are vulnerable to cannabis use. This should be considered by policymakers, individuals with commercial interests, the public, and mental h…

Early Intervention services in the era of genomic medicine: setting a research agenda Open

Katherine E. MacDuffie, Betty Cohn, Paul S. Appelbaum, Kyle B. Brothers, Dan Doherty , et al. · 2024

Ethical challenges in contemporary psychiatry: an overview and an appraisal of possible strategies and research needs Open

Silvana Galderisi, Paul S. Appelbaum, Neeraj Gill, Piers Gooding, Helen Herrman , et al. · 2024

Psychiatry shares most ethical issues with other branches of medicine, but also faces special challenges. The Code of Ethics of the World Psychiatric Association offers guidance, but many mental health care professionals are unaware of it …

Prevalence and incidence measures for schizophrenia among commercial health insurance and medicaid enrollees Open

Molly Finnerty, Atif Ali Khan, Kai You, Rui Wang, Gyojeong Gu , et al. · 2024

An open pilot trial of a behavioural intervention to reduce violence by young adults with early psychosis receiving treatment in an early intervention services setting: A protocol Open

Stephanie A. Rolin, Deirdre Caffrey, Megan G. Flores, Leah G. Pope, Jennifer J. Mootz , et al. · 2024

Aims Despite the public health impact of violence among young adults with psychosis, behavioural interventions to reduce the risk of engaging in violence remain rare. For young adults with early psychosis, cognitive behavioural therapy (CB…

Pilot study of a decision aid on BRCA1/2 genetic testing among Orthodox Jewish women Open

Meghna S. Trivedi, Haley Manley, Haeseung Yi, Thomas Silverman, Wendy K. Chung , et al. · 2024

Genetic sex validation for sample tracking in next-generation sequencing clinical testing Open

Jianhong Hu, Viktoriya Korchina, Hana Zouk, Maegan Harden, David R. Murdock , et al. · 2024

Objective Data from DNA genotyping via a 96-SNP panel in a study of 25,015 clinical samples were utilized for quality control and tracking of sample identity in a clinical sequencing network. The study aimed to demonstrate the value of bot…

Return of polygenic risk scores in research: Stakeholders’ views on the eMERGE-IV study Open

Maya Sabatello, Suzanne Bakken, Wendy K. Chung, Elizabeth Cohn, Katherine D. Crew , et al. · 2024

Physician‐assisted death for psychiatric disorders: ongoing reasons for concern Open

Paul S. Appelbaum · 2024

Physician-assisted death (PAD) – i.e., the prescription and administration of lethal medications by physicians – is increasingly available as an option for people struggling with psychiatric disorders. Although PAD was initially promoted a…

The chromatin landscape of healthy and injured cell types in the human kidney Open

Debora L. Gisch, Michelle Brennan, Blue B. Lake, Jeannine Basta, Mark S. Keller , et al. · 2024

Understanding Social, Cultural, and Religious Factors Influencing Medical Decision-Making on BRCA1/2 Genetic Testing in the Orthodox Jewish Community Open

Haeseung Yi, Meghna S. Trivedi, Katherine D. Crew, Isaac Schechter, Paul S. Appelbaum , et al. · 2024

Introduction: Although the prevalence of a pathogenic variant in the BRCA1 and BRCA2 genes is about 1:400 (0.25%) in the general population, the prevalence is as high as 1:40 (2.5%) among the Ashkenazi Jewish population. Despite cost-effec…

The safety of supported psilocybin use in Oregon Open

William Smith, Dominic Sisti, Paul S. Appelbaum · 2024

Parents' views of benefits and limitations of receiving genetic diagnoses for their offspring Open

Robert Klitzman, Ekaterina Bezborodko, Wendy K. Chung, Paul S. Appelbaum · 2023

Background Individuals with autism with intellectual disabilities (ID) are increasingly undergoing genetic testing, posing questions of how parents view/respond to such results. Methods Twenty‐eight parents whose offspring had received gen…

Receiving de novo genetic diagnoses for autism with intellectual disability: parents’ views of impacts on families’ reproductive decisions Open

Robert Klitzman, Ekaterina Bezborodko, Wendy K. Chung, Paul S. Appelbaum · 2023

Precision Medicine in Nephrology: An Integrative Framework of Multidimensional Data in the Kidney Precision Medicine Project Open

Tarek M. El‐Achkar, Michael T. Eadon, Matthias Kretzler, Jonathan Himmelfarb, Blue B. Lake , et al. · 2023

Ethical Challenges Associated with Advances in Genetic Prediction of Neuropsychiatric Disorders Open

Paul S. Appelbaum · 2023

From the earliest days of predictive genetic testing, concerns have been expressed about the potential negative consequences of informing people of their genetic risks.Most studies to date have suggested that the impact of genetic testing …

Maximizing Near-Term Clinical Opportunities for Psychiatric Genetics Open

Lea K. Davis, Paul S. Appelbaum, Jehannine Austin, Franziska Degenhardt, Sébastien Jacquemont , et al. · 2023

Over the past two decades, genomics research has been enormously successful in identifying specifi c genes, pathways, and mechanisms that play a role in the development of psychiatric and neurodevelopmental disorders.The translation of the…

Association of COVID-19 Versus COVID-19 Vaccination With Kidney Function and Disease Activity in Primary Glomerular Disease: A Report of the Cure Glomerulonephropathy Study Open

Chia-shi Wang, Dorey A. Glenn, Margaret Helmuth, Abigail R. Smith, Andrew S. Bomback , et al. · 2023

An atlas of healthy and injured cell states and niches in the human kidney Open

Blue B. Lake, Rajasree Menon, Seth Winfree, Qiwen Hu, Ricardo Melo Ferreira , et al. · 2023

Understanding kidney disease relies on defining the complexity of cell types and states, their associated molecular profiles and interactions within tissue neighbourhoods 1 . Here we applied multiple single-cell and single-nucleus assays (…

The Ethics of Risk Prediction for Psychosis and Suicide Attempt in Youth Mental Health Open

William Smith, Paul S. Appelbaum, Matthew S. Lebowitz, Sinan Gülöksüz, Monica E. Calkins , et al. · 2023

Lessons learned from the translation of the Internalised Stigma of Mental Illness (ISMI) scale into isiXhosa for use with South African Xhosa people with schizophrenia Open

Olivia P. Matshabane, Paul S. Appelbaum, Marlyn C. Faure, Patricia A. Marshall, Dan J. Stein , et al. · 2023

Internalised stigma is highly prevalent among people with mental illness. This is concerning because internalised stigma is often associated with negative consequences affecting individuals’ personal, familial, social, and overall wellbein…

Table of Contents Open

Dena R. Matalon, Cinthya Zepeda‐Mendoza, Mahmoud Aarabi, Kaitlyn Brown, Stephanie M. Fullerton , et al. · 2023

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