Paul S. Myles
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View article: Trajectories of new opioid use after hip fracture surgery: a population-based cohort study
Trajectories of new opioid use after hip fracture surgery: a population-based cohort study Open
Introduction: The global annual incidence of hip fractures is projected to double over the next 20 to 30 years. The rates and risk factors for new persistent opioid use after hip fracture surgery remain poorly quantified. Objective: To des…
View article: Antidepressant Effects of Nitrous Oxide in Major Depressive Disorder: A Phase 2b Randomized Clinical Trial
Antidepressant Effects of Nitrous Oxide in Major Depressive Disorder: A Phase 2b Randomized Clinical Trial Open
In this study, we confirmed that nitrous oxide has likely beneficial antidepressant effects in people with MDD.
View article: Analgesia using intrathecal morphine to improve quality of recovery after minimally invasive major abdominal surgery (AIM Trial): study protocol for a multicentre randomised controlled trial
Analgesia using intrathecal morphine to improve quality of recovery after minimally invasive major abdominal surgery (AIM Trial): study protocol for a multicentre randomised controlled trial Open
View article: Smoking and Complications After Cancer Surgery
Smoking and Complications After Cancer Surgery Open
Importance Surgical cancer treatments may be delayed for patients who smoke over concerns for increased risk of complications. Quantifying risks for people who had recently smoked can inform any trade-offs of delaying surgery. Objective To…
View article: Incidence of 12‐month postoperative cognitive decline following regional vs. general anaesthesia in older patients undergoing hip fracture surgery: follow‐up of the <scp>RAGA</scp> trial
Incidence of 12‐month postoperative cognitive decline following regional vs. general anaesthesia in older patients undergoing hip fracture surgery: follow‐up of the <span>RAGA</span> trial Open
Summary Introduction Data regarding the incidence of 12‐month postoperative cognitive decline following regional or general anaesthesia in older patients undergoing hip fracture surgery remain observational. Compared with general anaesthes…
View article: Effective utilisation of rapid infusion catheters in perioperative care: a narrative review
Effective utilisation of rapid infusion catheters in perioperative care: a narrative review Open
The Rapid Infusion Catheter (RIC) has transformed intravenous (i.v.) access, allowing for rapid fluid delivery peripherally. It may negate the need for a central vein sheath to be placed. This review explores the clinical utility of RICs w…
View article: Rationale and design of a large trial of perioperative ketamine for prevention of chronic post-surgical pain
Rationale and design of a large trial of perioperative ketamine for prevention of chronic post-surgical pain Open
Background Chronic post-surgical pain (CPSP) is recognised as one of the most common and debilitating complications of major surgery. Progression from acute to chronic pain after surgery involves sensitisation of central nervous system pat…
View article: Global collaboration between platform trials in surgery and anaesthesia
Global collaboration between platform trials in surgery and anaesthesia Open
Summary Large, randomized trials are the bedrock of evidence-based medicine, but the resources required to complete such trials greatly limit the number of important clinical questions that can be addressed within a reasonable period of ti…
View article: Critical care unit bed availability and postoperative outcomes: a multinational cohort study
Critical care unit bed availability and postoperative outcomes: a multinational cohort study Open
Summary Background Critical care beds are a limited resource, yet research indicates that recommendations for postoperative critical care admission based on patient‐level risk stratification are not followed. It is unclear how prioritisati…
View article: PeriOperative Quality Initiative (POQI) international consensus statement on perioperative arterial pressure management
PeriOperative Quality Initiative (POQI) international consensus statement on perioperative arterial pressure management Open
Arterial pressure monitoring and management are mainstays of haemodynamic therapy in patients having surgery. This article presents updated consensus statements and recommendations on perioperative arterial pressure management developed du…
View article: Rationale and design of the early valve replacement in severe asymptomatic aortic stenosis trial
Rationale and design of the early valve replacement in severe asymptomatic aortic stenosis trial Open
The EASY-AS trial will establish whether a strategy of early aortic valve replacement in asymptomatic patients with severe aortic stenosis reduces cardiovascular mortality or heart failure hospitalization and improves other important outco…
View article: Tranexamic acid in trauma: After 3 hours from injury, when is it safe and effective to use again?
Tranexamic acid in trauma: After 3 hours from injury, when is it safe and effective to use again? Open
Tranexamic acid (TXA) has proven mortality benefit if used early after traumatic injury, likely related to a combination of bleeding reduction and other non‐bleeding effects. If TXA is given more than 3 h after traumatic injury, there is a…
View article: Associations between the intraoperative fraction of inspired intraoperative oxygen administration and days alive and out of hospital after surgery
Associations between the intraoperative fraction of inspired intraoperative oxygen administration and days alive and out of hospital after surgery Open
View article: Days at home alive after major surgery in patients with and without diabetes: an observational cohort study
Days at home alive after major surgery in patients with and without diabetes: an observational cohort study Open
Objective We hypothesized that days at home alive up to 30 days after surgery (DAH30), a novel patient-centered outcome metric, as well as long-term mortality, would be impaired in patients with type 1 or 2 diabetes mellitus (DM) undergoin…
View article: Cystatin C or creatinine for pre-operative assessment of kidney function and risk of post-operative acute kidney injury: a secondary analysis of the METS cohort study
Cystatin C or creatinine for pre-operative assessment of kidney function and risk of post-operative acute kidney injury: a secondary analysis of the METS cohort study Open
Background Post-operative acute kidney injury (PO-AKI) is a common surgical complication consistently associated with subsequent morbidity and mortality. Prior kidney dysfunction is a major risk factor for PO-AKI, however it is unclear whe…
View article: Machine learning to predict myocardial injury and death after non-cardiac surgery
Machine learning to predict myocardial injury and death after non-cardiac surgery Open
Background/Introduction Myocardial injury after non-cardiac surgery (MINS) is defined as prognostically relevant myocardial injury due to ischaemia that occurs within 30-days of non-cardiac surgery. Purpose The aim of this study was to tes…
View article: A mixed methods study protocol to identify research priorities for perioperative medicine in Australia
A mixed methods study protocol to identify research priorities for perioperative medicine in Australia Open
Ethical approval to conduct the study was obtained from the Alfred Health (Australia) Human Research Ethics Committee (ID: 171/19). The findings will be disseminated in peer review publications, conferences, and dissemination across periop…
View article: Benefits and harms of perioperative high fraction inspired oxygen for surgical site infection prevention: a protocol for a systematic review and meta-analysis of individual patient data of randomised controlled trials
Benefits and harms of perioperative high fraction inspired oxygen for surgical site infection prevention: a protocol for a systematic review and meta-analysis of individual patient data of randomised controlled trials Open
Introduction The use of high fraction of inspired oxygen (FiO 2 ) intraoperatively for the prevention of surgical site infection (SSI) remains controversial. Promising results of early randomised controlled trials (RCT) have been replicate…
View article: Tranexamic acid for haemostasis and beyond: does dose matter?
Tranexamic acid for haemostasis and beyond: does dose matter? Open
View article: Issue Information – Editorial Board
Issue Information – Editorial Board Open
View article: Postoperative systemic inflammation after major abdominal surgery: patient‐centred outcomes
Postoperative systemic inflammation after major abdominal surgery: patient‐centred outcomes Open
Summary Postoperative systemic inflammation is strongly associated with surgical outcomes, but its relationship with patient‐centred outcomes is largely unknown. Detection of excessive inflammation and patient and surgical factors associat…
View article: Postoperative analgesia for upper gastrointestinal surgery: a retrospective cohort analysis
Postoperative analgesia for upper gastrointestinal surgery: a retrospective cohort analysis Open
Background Thoracic epidural analgesia is commonly used for upper gastrointestinal surgery. Intrathecal morphine is an appealing opioid-sparing non-epidural analgesic option, especially for laparoscopic gastrointestinal surgery. Methods Fo…
View article: Issue Information – Editorial Board
Issue Information – Editorial Board Open
Early warning scores: the case for aggregate vs. single extreme parameter activation to detect patient deterioration M.
View article: Treatments for major depression
Treatments for major depression Open
View article: Contents
Contents Open
View article: Universal research index: An inclusive metric to quantify scientific research output
Universal research index: An inclusive metric to quantify scientific research output Open
Scientometrics and bibliometrics, the subfields of library and information science, deal with the quantity and quality of research outputs. Currently, various scientometric indices are being used to quantify and compare research outputs. T…
View article: Machine learning to predict myocardial injury and death after non‐cardiac surgery
Machine learning to predict myocardial injury and death after non‐cardiac surgery Open
Summary Myocardial injury due to ischaemia within 30 days of non‐cardiac surgery is prognostically relevant. We aimed to determine the discrimination, calibration, accuracy, sensitivity and specificity of single‐layer and multiple‐layer ne…
View article: Data from Preoperative β-Blockade with Propranolol Reduces Biomarkers of Metastasis in Breast Cancer: A Phase II Randomized Trial
Data from Preoperative β-Blockade with Propranolol Reduces Biomarkers of Metastasis in Breast Cancer: A Phase II Randomized Trial Open
Purpose:The majority of deaths from breast cancer occur following the development of metastatic disease, a process inhibited by β-blockers in preclinical studies. This phase II randomized controlled trial evaluated the effect of preoperati…
View article: Data from Preoperative β-Blockade with Propranolol Reduces Biomarkers of Metastasis in Breast Cancer: A Phase II Randomized Trial
Data from Preoperative β-Blockade with Propranolol Reduces Biomarkers of Metastasis in Breast Cancer: A Phase II Randomized Trial Open
Purpose:The majority of deaths from breast cancer occur following the development of metastatic disease, a process inhibited by β-blockers in preclinical studies. This phase II randomized controlled trial evaluated the effect of preoperati…
View article: Supplementary Material from Preoperative β-Blockade with Propranolol Reduces Biomarkers of Metastasis in Breast Cancer: A Phase II Randomized Trial
Supplementary Material from Preoperative β-Blockade with Propranolol Reduces Biomarkers of Metastasis in Breast Cancer: A Phase II Randomized Trial Open
Supplementary Material