Paul Sample
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Human 5′ UTR design and variant effect prediction from a massively parallel translation assay Open
Predicting the impact of cis -regulatory sequence on gene expression is a foundational challenge for biology. We combine polysome profiling of hundreds of thousands of randomized 5′ UTRs with deep learning to build a predictive model that …
Single-cell profiling of the developing mouse brain and spinal cord with split-pool barcoding Open
Identifying single-cell types in the mouse brain The recent development of single-cell genomic techniques allows us to profile gene expression at the single-cell level easily, although many of these methods have limited throughput. Rosenbe…