Paul Sandstrom
YOU?
Author Swipe
View article: HIV Drug Resistance Among Key Populations in Nigeria: Insights From the 2020 Integrated Biological and Behavioral Surveillance Survey
HIV Drug Resistance Among Key Populations in Nigeria: Insights From the 2020 Integrated Biological and Behavioral Surveillance Survey Open
Objectives: HIV drug resistance mutations (DRMs) undermine the effectiveness of antiretroviral therapy (ART) and can lead to treatment failure. This study aimed to characterize HIV drug resistance among key populations in Nigeria. Design: …
View article: “Big Events” and HIV Transmission Dynamics: Estimating Time Since HIV Infection from Deep Sequencing Data Among Sex Workers and Their Clients in Dnipro, Ukraine
“Big Events” and HIV Transmission Dynamics: Estimating Time Since HIV Infection from Deep Sequencing Data Among Sex Workers and Their Clients in Dnipro, Ukraine Open
Background: Major geopolitical events and structural shocks are thought to play a significant role in shaping HIV epidemics by influencing individual behaviours, reshaping social networks, and impacting HIV prevention and treatment program…
View article: “Big Events” and HIV transmission dynamics: estimating time since HIV infection from deep sequencing data among sex workers and their clients in Dnipro, Ukraine
“Big Events” and HIV transmission dynamics: estimating time since HIV infection from deep sequencing data among sex workers and their clients in Dnipro, Ukraine Open
Background Major geopolitical events and structural shocks are thought to play a significant role in shaping HIV epidemics by influencing individual behaviours, reshaping social networks, and impacting HIV prevention and treatment programs…
View article: Identification of circulating human papillomavirus types through high-throughput sequencing of Canadian municipal and institutional wastewater samples
Identification of circulating human papillomavirus types through high-throughput sequencing of Canadian municipal and institutional wastewater samples Open
Human papillomaviruses (HPVs) are a diverse group of viruses that infect human mucosal and cutaneous tissues, with a ubiquitous global distribution. Several types are classified as high-risk due to their association with cervical, anal, pe…
View article: Detectability of cytokine and chemokine using ELISA, following sample-inactivation using Triton X-100 or heat
Detectability of cytokine and chemokine using ELISA, following sample-inactivation using Triton X-100 or heat Open
Clinical samples are routinely inactivated before molecular assays to prevent pathogen transmission. Antibody-based assays are sensitive to changes in analyte conformation, but the impact of inactivation on the analyte detectability has be…
View article: Joint HIV and hepatitis C virus phylogenetic analyses signal network overlap among women engaged in sex work and men who purchase sex
Joint HIV and hepatitis C virus phylogenetic analyses signal network overlap among women engaged in sex work and men who purchase sex Open
Background Transmission of HIV and hepatitis C virus (HCV) are heavily influenced by complex interactions within sexual or injecting networks where risk behaviors occur. In Ukraine, women engaged in sex work (WSW) and men who purchase sex …
View article: HIV Phylogenetic Clusters Point to Unmet HIV Prevention, Testing and Treatment Needs Among Men Who Have Sex with Men in Kenya
HIV Phylogenetic Clusters Point to Unmet HIV Prevention, Testing and Treatment Needs Among Men Who Have Sex with Men in Kenya Open
Background The HIV epidemic in Kenya remains a significant public health concern, particularly among gay, bisexual, and other men who have sex with men (GBMSM), who continue to bear a disproportionate burden of the epidemic. This study’s o…
View article: Validity of dried blood spot testing for sexually transmitted and blood-borne infections: A narrative systematic review
Validity of dried blood spot testing for sexually transmitted and blood-borne infections: A narrative systematic review Open
Testing for human immunodeficiency virus (HIV) and hepatitis C virus (HCV) using dried blood spot (DBS) specimens has been an integral part of bio-behavioural surveillance in Canada for almost two decades, though less is known regarding th…
View article: Treponemal point-of-care tests for syphilis
Treponemal point-of-care tests for syphilis Open
Increasing screening uptake is important to reversing the rising rates of syphilis and congenital syphilis in Canada.[1][1],[2][2] Conventional screening for syphilis involves serologic laboratory testing.[1][1]–[4][3] Barriers to accessin…
View article: Post-market surveillance of six COVID-19 point-of-care tests using pre-Omicron and Omicron SARS-CoV-2 variants
Post-market surveillance of six COVID-19 point-of-care tests using pre-Omicron and Omicron SARS-CoV-2 variants Open
Post-market surveillance of test performance is a critical function of public health agencies and clinical researchers that ensures tests maintaining diagnostic characteristics following their regulatory approval. Changes in product qualit…
View article: Notable transmitted HIV drug resistance among people who inject drugs in Pakistan
Notable transmitted HIV drug resistance among people who inject drugs in Pakistan Open
Transmission of drug-resistant HIV strains to treatment-naïve patients can compromise antiretroviral therapy (ART) effectiveness and lead to treatment failure. In Pakistan, transmitted HIV drug resistance among people who inject drugs (PWI…
View article: Detectability of Cytokine and Chemokine using ELISA, following Sample-inactivation using Triton X-100 or Heat
Detectability of Cytokine and Chemokine using ELISA, following Sample-inactivation using Triton X-100 or Heat Open
Background Routine characterization of clinical samples for their immunological responses against infectious pathogens often involves assessing cytokine/chemokine profiles and/or production of pathogen-specific antibodies. To prevent tran…
View article: Differential Burden of HIV Among Adolescent Girls and Young Women by Places Associated With Sex Work: An Observational Study in Mombasa, Kenya
Differential Burden of HIV Among Adolescent Girls and Young Women by Places Associated With Sex Work: An Observational Study in Mombasa, Kenya Open
Background: The design of HIV prevention programs for adolescent girls and young women (AGYW) are informed by data on who is at highest risk and where they can be reached. Places (hotspots) associated with selling sex are an established ou…
View article: A validated in-house assay for HIV drug resistance mutation surveillance from dried blood spot specimens
A validated in-house assay for HIV drug resistance mutation surveillance from dried blood spot specimens Open
Despite increasing scale-up of antiretroviral therapy (ART) coverage, challenges related to adherence and HIV drug resistance (HIVDR) remain. The high cost of HIVDR surveillance is a persistent challenge with implementation in resource-con…
View article: Post-Market Surveillance of Six COVID-19 Point-of-Care Tests Using Pre-Omicron and Omicron SARS-CoV-2 Variants
Post-Market Surveillance of Six COVID-19 Point-of-Care Tests Using Pre-Omicron and Omicron SARS-CoV-2 Variants Open
Post-market surveillance of test performance is a critical function of public health agencies and clinical researchers that ensures diagnostics maintain performance characteristics following their regulatory approval. Changes in product qu…
View article: Current Progress in Genomic and Genetic Research on Human Viral Diseases
Current Progress in Genomic and Genetic Research on Human Viral Diseases Open
it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed.The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge.Front…
View article: A cross-sectional survey exploring HIV and HCV prevalence among men who purchase sex in Dnipro, Ukraine
A cross-sectional survey exploring HIV and HCV prevalence among men who purchase sex in Dnipro, Ukraine Open
Background HIV programming in Ukraine largely targets “key population” groups. Men who purchase sex are not directly reached. The aim of our study was to explore the prevalence of sexually transmitted and blood-borne infections (STBBIs) am…
View article: Tracking the evolution of the SARS-CoV-2 Delta variant of concern: analysis of genetic diversity and selection across the whole viral genome
Tracking the evolution of the SARS-CoV-2 Delta variant of concern: analysis of genetic diversity and selection across the whole viral genome Open
Background Since 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has diversified extensively, producing five highly virulent lineages designated as variants of concern (VOCs). The Delta VOC emerged in India with increase…
View article: <i>Gardnerella</i> Revisited: Species Heterogeneity, Virulence Factors, Mucosal Immune Responses, and Contributions to Bacterial Vaginosis
<i>Gardnerella</i> Revisited: Species Heterogeneity, Virulence Factors, Mucosal Immune Responses, and Contributions to Bacterial Vaginosis Open
Gardnerella species are associated with bacterial vaginosis (BV) and have been investigated as etiological agents of the condition. Nonetheless, the isolation of this taxon from healthy individuals has raised important questions regarding …
View article: Validity of Dried Blood Spot Testing for Sexually Transmitted and Blood-Borne Infections: A Narrative Systematic Review
Validity of Dried Blood Spot Testing for Sexually Transmitted and Blood-Borne Infections: A Narrative Systematic Review Open
Objective Testing for human immunodeficiency virus (HIV) and hepatitis C virus (HCV) using dried blood spot (DBS) specimens has been an integral part of bio-behavioural surveillance in Canada for almost two decades. A systematic review was…
View article: HIV acquisition prior to entry into formal sex work: inference from next-generation viral sequencing
HIV acquisition prior to entry into formal sex work: inference from next-generation viral sequencing Open
Objective: To infer the timing of HIV acquisition in relation to self-reported events in the sexual life course of adolescent girls and young women (AGYW) who self-identify as female sex workers (FSW) in Mombasa, Kenya. Design: Next-genera…
View article: Clinical evaluation of the GeneXpert <sup>®</sup> Xpert <sup>®</sup> Xpress SARS-CoV-2/Flu/RSV PLUS combination test
Clinical evaluation of the GeneXpert <sup>®</sup> Xpert <sup>®</sup> Xpress SARS-CoV-2/Flu/RSV PLUS combination test Open
The GeneXpert ® Xpert ® Xpress SARS-CoV-2/Flu/RSV PLUS combination test (PLUS assay) received Health Canada approval in January 2022. The PLUS assay is similar to the SARS-CoV-2/Flu/RSV combination test, with modifications to improve assay…
View article: Gardnerella subgroup dominant microbiomes are associated with divergent cervicovaginal immune responses in a longitudinal cohort of Kenyan women
Gardnerella subgroup dominant microbiomes are associated with divergent cervicovaginal immune responses in a longitudinal cohort of Kenyan women Open
Most cervicovaginal microbiome-immunology studies to date have relied on 16S rDNA microbial profiling which does not resolve the molecular subgroups of Gardnerella , believed to be central to the pathogenesis of bacterial vaginosis (BV) an…
View article: Community Insights in Phylogenetic HIV Research: The CIPHR Project Protocol
Community Insights in Phylogenetic HIV Research: The CIPHR Project Protocol Open
Inferring HIV transmission networks from HIV sequences is gaining popularity in the field of HIV molecular epidemiology. However, HIV sequences are often analyzed at distance from those affected by HIV epidemics, namely without the involve…
View article: Clinical Evaluation of the GeneXpert<sup>®</sup>Xpert<sup>®</sup>Xpress SARS-CoV-2/Flu/RSV<i>PLUS</i>Combination Test
Clinical Evaluation of the GeneXpert<sup>®</sup>Xpert<sup>®</sup>Xpress SARS-CoV-2/Flu/RSV<i>PLUS</i>Combination Test Open
The GeneXpert ® Xpert ® Xpress SARS-CoV-2/Flu/RSV PLUS combination test ( PLUS Assay) received Health Canada approval in January 2022. The PLUS Assay is similar to the SARS-CoV-2/Flu/RSV combination test, with modifications to improve assa…
View article: Overview of the Analytes Applied in Genotypic HIV Drug Resistance Testing
Overview of the Analytes Applied in Genotypic HIV Drug Resistance Testing Open
The close monitoring of HIV drug resistance using genotypic HIV drug resistance testing (HIVDRT) has become essential for effective HIV/AIDS management at both individual and population levels. Over the years, a broad spectrum of analytes …
View article: Evaluation of the bioMérieux VIDAS HIV Duo Quick and Anti-HCV assays for dried blood spot based serosurveillance
Evaluation of the bioMérieux VIDAS HIV Duo Quick and Anti-HCV assays for dried blood spot based serosurveillance Open
Serosurveillance is central to monitoring our progress towards HIV and HCV elimination targets proposed for 2030. However, serosurveillance systems are ineffective without reliable serological assays for the detection of HIV and HCV antibo…
View article: CAVES: A Novel Tool for Comparative Analysis of Variant Epitope Sequences
CAVES: A Novel Tool for Comparative Analysis of Variant Epitope Sequences Open
In silico methods for immune epitope prediction have become essential for vaccine and therapeutic design, but manual intra-species comparison of putative epitopes remains challenging and subject to human error. Created initially for analyz…
View article: Phylogeographic Assessment Reveals Geographic Sources of HIV-1 Dissemination Among Men Who Have Sex With Men in Kenya
Phylogeographic Assessment Reveals Geographic Sources of HIV-1 Dissemination Among Men Who Have Sex With Men in Kenya Open
HIV-1 transmission dynamics involving men who have sex with men (MSM) in Africa are not well understood. We investigated the rates of HIV-1 transmission between MSM across three regions in Kenya: Coast, Nairobi, and Nyanza. We analyzed 372…