Explanipedia

Theoretical optimal Th target thicknesses for Ac production at proton energies of 70–200 MeV Open

J. S. Jang, Paul Schaffer, Valery Radchenko, Louis Moskven, Nobuyoshi Akimitsu , et al. · 2025

Objective . Conventional Th target thicknesses used for Ac production are substantially smaller than the proton ranges, underutilizing the Ac production potential of proton beams. This study explores theoretical optimal t…

Adverse childhood experiences and problematic use of the internet among a child and adolescent psychiatric clinical population. Open

Kornelius Winds, Belinda Plattner, Bernhard Salcher, Patrick B. Langthaler, Gabriele Kohlböck , et al. · 2025

Extrafamilial emotional abuse, particularly social receptive environments and relationships, play a significant role in developing PUI among CAP populations. The complex interplay of emotional trauma, family dynamics, peer relationships an…

Evaluating a triaza-18-crown-6 picolinate chelator for [ 212/203 Pb]Pb 2+ and [ 212/213 Bi]Bi 3+ theranostics Open

Desiree Fiaccabrino, Tinotenda Rose Masvikeni, Brooke L. McNeil, Brian O. Patrick, Marı́a de Guadalupe Jaraquemada-Peláez , et al. · 2025

Triaza-18-crown-6-based macrocycle, H 3 tripa, rapidly forms stable complexes with 203 Pb and 213 Bi; structural, thermodynamic, and computational data support H 3 tripa as a dual-purpose chelator for Pb/Bi-based radiotheranostics.

Quantitative SPECT imaging of 155Tb and 161Tb for preclinical theranostic radiopharmaceutical development Open

Helena Koniar, Scott McNeil, Luke Wharton, Aidan Ingham, Michiel Van de Voorde , et al. · 2024

Background Element-equivalent matched theranostic pairs facilitate quantitative in vivo imaging to establish pharmacokinetics and dosimetry estimates in the development of preclinical radiopharmaceuticals. Terbium radionuclides have signif…

In vivo quantitative SPECT imaging of actinium-226: feasibility and proof-of-concept Open

Helena Koniar, Luke Wharton, Aidan Ingham, Cristina Rodríguez‐Rodríguez, P. Kunz , et al. · 2024

Objective . 225 Ac radiopharmaceuticals have tremendous potential for targeted alpha therapy, however, 225 Ac ( t 1/2 = 9.9 d) lacks direct gamma emissions for in vivo imaging. 226 Ac ( t 1/2 = 29.4 h) is a promising element-equivalent mat…

Misfolded protein deposits in Parkinson’s disease and Parkinson’s disease-related cognitive impairment, a [11C]PBB3 study Open

Michele Matarazzo, Alexandra Pérez‐Soriano, Nasim Vafai, Elham Shahinfard, Kevin Ju-Chieh Cheng , et al. · 2024

A GATE simulation study for dosimetry in cancer cell and micrometastasis from the 225Ac decay chain Open

Helena Koniar, Cassandra Miller, Arman Rahmim, Paul Schaffer, Carlos Uribe · 2023

Optimized production, purification, and radiolabeling of the 203Pb/212Pb theranostic pair for nuclear medicine Open

Brooke L. McNeil, Simona A. Mastroianni, Scott McNeil, Stefan Zeisler, Joel Kumlin , et al. · 2023

Comparative Evaluation of [18F]5-Fluoroaminosuberic Acid and (4S)-4-3-[18F]fluoropropyl)-l-Glutamate as System –Targeting Radiopharmaceuticals Open

Milena Čolović, Hua Yang, Lily Southcott, Helen Merkens, Nadine Colpo , et al. · 2023

System [Formula: see text] is an appealing biomarker for targeting oxidative stress with oncologic PET imaging and can serve as an alternative PET biomarker to other metabolic indicators. In this paper, we report a direct comparison of 2 <…

Preclinical Evaluation of [155/161Tb]Tb-Crown-TATE—A Novel SPECT Imaging Theranostic Agent Targeting Neuroendocrine Tumours Open

Luke Wharton, Scott McNeil, Helen Merkens, Zheliang Yuan, Michiel Van de Voorde , et al. · 2023

Terbium radioisotopes (149Tb, 152Tb, 155Tb, 161Tb) offer a unique class of radionuclides which encompass all four medicinally relevant nuclear decay modalities (α, β+, γ, β−/e−), and show high potential for the development of element-match…

Toward 68Ga and 64Cu Positron Emission Tomography Probes: Is H2dedpa-N,N′-pram the Missing Link for dedpa Conjugation? Open

Celia Pena-Bonhome, Desiree Fiaccabrino, Tamara Rama, Daniel Fernández-Pavón, Lily Southcott , et al. · 2023

H₂dedpa-N,N'-pram (H₂L¹), a new chelator derived from the hexadentate ligand 1,2-bis[[(6-carboxypyridin-2-yl)methyl]amino]ethane (H₂dedpa), which incorporates 3-propylamine chains a…

Evaluation of the Effect of Macrocyclic Ring Size on [203Pb]Pb(II) Complex Stability in Pyridyl-Containing Chelators Open

Brooke L. McNeil, Karthika J. Kadassery, Anthony W. McDonagh, Wen Zhou, Paul Schaffer , et al. · 2022

As an element-equivalent theranostic pair, lead-203 (²⁰³Pb, 100% EC, half-life = 51.92 h) and lead-212 (²¹²Pb, 100% β^-, half-life = 10.64 h), through the emission of γ rays and an α particle in its decay ch…

Radiolabeling of a polypeptide polymer for intratumoral delivery of alpha-particle emitter, 225Ac, and beta-particle emitter, 177Lu Open

Vladimir Shalgunov, Gokce Engudar, Lennart Bohrmann, Luke Wharton, Keiran Maskell , et al. · 2021

Harnessing α-Emitting Radionuclides for Therapy: Radiolabeling Method Review Open

Hua Yang, Justin J. Wilson, Chris Orvig, Yawen Li, D. Scott Wilbur , et al. · 2021

Targeted α-therapy (TAT) is an emerging powerful tool treating late-stage cancers for which therapeutic options are limited. At the core of TAT are targeted radiopharmaceuticals, where isotopes are paired with targeting vectors to enable t…

Production and Supply of α-Particle–Emitting Radionuclides for Targeted α-Therapy Open

Valery Radchenko, Alfred Morgenstern, Amir Reza Jalilian, Caterina F. Ramogida, Cathy Cutler , et al. · 2021

Encouraging results from targeted α-therapy have received significant attention from academia and industry. However, the limited availability of suitable radionuclides has hampered widespread translation and application. In the present rev…

Hybrid Metal–Phenol Nanoparticles with Polydopamine-like Coating for PET/SPECT/CT Imaging Open

Salvio Suárez–García, Tullio Esposito, Jenna Neufeld-Peters, Marta Bergamo, Hua Yang , et al. · 2021

The validation of metal-phenolic nanoparticles (MPNs) in preclinical imaging studies represents a growing field of interest due to their versatility in forming predesigned structures with unique properties. Before MPNs can be used in medic…

Production, purification, and radiolabeling of the 203Pb/212Pb theranostic pair Open

Brooke L. McNeil, Andrew K. H. Robertson, Winnie Fu, Hua Yang, Cornelia Hoehr , et al. · 2021

Synthesis of DOTA-pyridine chelates for 64Cu coordination and radiolabeling of αMSH peptide Open

Hua Yang, Feng Gao, Brooke L. McNeil, Chengcheng Zhang, Zheliang Yuan , et al. · 2021

Multi-curie production of gallium-68 on a biomedical cyclotron and automated radiolabelling of PSMA-11 and DOTATATE Open

Helge Thisgaard, Joel Kumlin, Niels Langkjær, Jansen Chua, B. Hook , et al. · 2021

Expanding the PET radioisotope universe utilizing solid targets on small medical cyclotrons Open

Krystle George, S. Borjian, Michael Cross, Justin W. Hicks, Paul Schaffer , et al. · 2021

The production of novel radioisotopes on small-to-medium cyclotrons equipped with solid targets will be vital to meet the demand of theragnostics research.

Production, Purification, and Radiolabeling of the 203Pb/212Pb Theranostic Pair Open

Brooke L. McNeil, Andrew K. H. Robertson, Winnie Fu, Hua Yang, Cornelia Hoehr , et al. · 2020

Background: Lead-212 ( 212 Pb, t 1/2 = 10.6 h) and lead-203 ( 203 Pb, t 1/2 = 51.9 h) are an element-equivalent, or a matched theranostic radioisotope pair that show great potential for application in targeted radionuclide therapy (TRT) an…

Lewis Acid-Facilitated Radiofluorination of MN3PU: A LRRK2 Radiotracer Open

Noeen Malik, Shreya Bendre, Ralf Schirrmacher, Paul Schaffer · 2020

Background: Temperature-sensitive radiopharmaceutical precursors require lower reaction temperatures (<100 °C) during nucleophilic radiofluorination in order to avoid compound thermolysis, often resulting in sub-optimal radiochemical yield…

Synthesis of DOTA-Pyridine Chelates for 64Cu Coordination and Radiolabeling of αMSH Peptide Open

Hua Yang, Feng Gao, Brooke L. McNeil, Chengcheng Zhang, Stefan Zeisler , et al. · 2020

Background : ⁶⁴Cu is one of the few radioisotopes that can be used for both imaging and therapy, enabling theranostics with identical chemical composition. Development of stable chelators is essential to harness the potential of…

Multi-curie Production of Gallium-68 on a Biomedical Cyclotron and Automated Radiolabelling of PSMA-11 and DOTATATE Open

Helge Thisgaard, Joel Kumlin, Niels Langkjær, Jansen Chua, Brian Hook , et al. · 2020

Background: With increasing clinical demand for gallium-68, commercial germanium-68/gallium-68 ([ 68 Ge]Ge/[ 68 Ga]Ga) generators are incapable of supplying sufficient amounts of the short-lived daughter isotope. In this study, we demonstr…

Multi-Curie Production of Gallium-68 on a Biomedical Cyclotron and Automated Radiolabelling of PSMA-11 and DOTATATE Open

Helge Thisgaard, Joel Kumlin, Niels Langkjær, Jansen Chua, Brian Hook , et al. · 2020

Background: With increasing clinical demand for gallium-68, commercial germanium-68/gallium-68 ([⁶⁸Ge]Ge/[⁶⁸Ga]Ga) generators are incapable of supplying sufficient amounts of the short-lived daughter isotope. In this …

Self-reported food choices before and during COVID-19 lockdown Open

Ellen Siobhan Mitchell, Qiuchen Yang, Heather Behr, Laura DeLuca, Paul Schaffer · 2020

Stressful situations can cause changes in individual food choices, most notably, choices of highly rewarding foods that are high in fat or sugar. Few studies have examined how a population’s food choices change during a country-wide stress…

[nat/44Sc(pypa)]−: Thermodynamic Stability, Radiolabeling, and Biodistribution of a Prostate-Specific-Membrane-Antigen-Targeting Conjugate Open

Lily Li, Marı́a de Guadalupe Jaraquemada-Peláez, Eduardo Aluicio‐Sarduy, Xiaozhu Wang, Dawei Jiang , et al. · 2020

⁴⁴Sc is an attractive positron-emitting radionuclide for PET imaging; herein, a new complex of the Sc³⁺ ion with nonmacrocyclic chelator H₄pypa was synthesized and characterized with high-resolution electro…

Coordination chemistry of [Y(pypa)]− and comparison immuno-PET imaging of [44Sc]Sc- and [86Y]Y-pypa-phenyl-TRC105 Open

Lily Li, Marı́a de Guadalupe Jaraquemada-Peláez, Eduardo Aluicio‐Sarduy, Xiaozhu Wang, Todd E. Barnhart , et al. · 2020

H₄pypa was conjugated to an antibody via a newly synthesized H₄pypa-phenyl-NCS; promising immuno-PET imaging with 44Sc was demonstrated.

Medical isotope collection from ISAC targets Open

P. Kunz, C. Andreoiu, Victoria Brown, Marla Cervantes, J. Even , et al. · 2020

The ISAC facility (Isotope Separation and Acceleration) at TRIUMF has recently started to provide isotopes for pre-clinical nuclear medicine studies. By irradiating ISOL (Isotope Separation OnLine) targets with a 480 MeV proton beam from t…

Evaluation of polydentate picolinic acid chelating ligands and an α-melanocyte-stimulating hormone derivative for targeted alpha therapy using ISOL-produced 225Ac Open

Caterina F. Ramogida, Andrew K. H. Robertson, Una Jermilova, Chengcheng Zhang, Hua Yang , et al. · 2019

Paul Schaffer YOU? Author Swipe