Paul Schnacke
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View article: The functional landscape of the human ubiquitinome
The functional landscape of the human ubiquitinome Open
Protein ubiquitination regulates cell biology through diverse avenues, from quality control-linked protein degradation to signaling functions such as modulating protein-protein interactions and enzyme activation. Mass spectrometry-based pr…
View article: Genetic Code Expansion Facilitates Programmable Ubiquitylation via UBE2W
Genetic Code Expansion Facilitates Programmable Ubiquitylation via UBE2W Open
Deciphering the ubiquitin code requires homogenous, site-specifically ubiquitylated proteins, yet their access remains difficult. Current chemical and enzymatic methods are often limited by harsh conditions, low yields, or the introduction…
View article: Real-Time Optical Control of CB1 Receptor Signaling In Vitro with Tethered Photoswitchable THC Derivatives
Real-Time Optical Control of CB1 Receptor Signaling In Vitro with Tethered Photoswitchable THC Derivatives Open
Understanding the intricacies of the endocannabinoid system is hindered by the lack of tools to target specific pools of CB1 receptors (CB1Rs) across diverse neural circuits associated with mood, motor function, cognition, and other physio…
View article: Probing coenzyme A homeostasis with semisynthetic biosensors
Probing coenzyme A homeostasis with semisynthetic biosensors Open
Coenzyme A (CoA) is one of the central cofactors of metabolism, yet a method for measuring its concentration in living cells is missing. Here we introduce the first biosensor for measuring CoA levels in different organelles of mammalian ce…