Jong Seo Lee
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View article: Combined effect of probiotics and omega-3 fatty acids on blood and liver function biomarkers and gut microbiota diversity in male mice with high fat diet-induced obesity
Combined effect of probiotics and omega-3 fatty acids on blood and liver function biomarkers and gut microbiota diversity in male mice with high fat diet-induced obesity Open
This study investigates the combined effects of probiotics and omega-3 fatty acids on blood and liver function biomarkers, as well as gut microbiota diversity, in a high-fat diet (HFD)-induced obesity model in male mice. Cardiovascular dis…
View article: Isolation and Characterization of Lactobacillus gasseri Strains from Women for Potential Vaginal Health Applications
Isolation and Characterization of Lactobacillus gasseri Strains from Women for Potential Vaginal Health Applications Open
Lactobacillus, a genus of lactic acid bacteria, is known to coexist symbiotically in the female vaginal microbiota and has gained attention as a potential probiotic with benefits for female reproductive health. This study aimed to evaluate…
View article: Alternative translation initiation produces synaptic organizer proteoforms with distinct localization and functions
Alternative translation initiation produces synaptic organizer proteoforms with distinct localization and functions Open
While previous studies suggest that many mRNAs contain more than one translation initiation site (TIS), the biological significance of most alternative TISs and their corresponding protein isoforms (proteoforms) remains undetermined. Here …
View article: Combination of <i>Lacticaseibacillus paracasei</i> BEPC22 and <i>Lactiplantibacillus plantarum</i> BELP53 attenuates fat accumulation and alters the metabolome and gut microbiota in mice with high-fat diet-induced obesity
Combination of <i>Lacticaseibacillus paracasei</i> BEPC22 and <i>Lactiplantibacillus plantarum</i> BELP53 attenuates fat accumulation and alters the metabolome and gut microbiota in mice with high-fat diet-induced obesity Open
This study evaluated the effects of formulations with Lacticaseibacillus paracasei BEPC22 and Lactiplantibacillus plantarum BELP53 on adiposity, the alteration of microbiota, and the metabolome in high-fat diet-fed mice.
View article: A First-in-Human Phase I Study of AT101, a Novel Anti-CD19 Chimeric Antigen Receptor T Cell Product Targeting a Membrane-Proximal Domain of CD19 in Adults with Relapsed or Refractory B Cell Non-Hodgkin Lymphoma
A First-in-Human Phase I Study of AT101, a Novel Anti-CD19 Chimeric Antigen Receptor T Cell Product Targeting a Membrane-Proximal Domain of CD19 in Adults with Relapsed or Refractory B Cell Non-Hodgkin Lymphoma Open
Introduction: Anti-CD19 chimeric antigen receptor T-cell therapies (CART19) are highly efficacious against advanced B cell non-Hodgkin lymphoma (NHL) but the majority of patients (pts) ultimately fail. Several mechanisms contribute to CART…
View article: Reduction of nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43–related neurodegeneration
Reduction of nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43–related neurodegeneration Open
Protein aggregation is a hallmark of many neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). Although mutations in TARDBP, encoding transactive response DNA-binding protein 43 kDa (TDP-43), account for less than 1%…
View article: Typhoid fever presenting with gastric ulcer bleeding
Typhoid fever presenting with gastric ulcer bleeding Open
Background Enteric fever is a systemic disease caused by Salmonella enterica serovar Typhi or Salmonella enterica serovar Paratyphi, characterized by high fever and abdominal pain. Most patients with enteric fever improve within a few days…
View article: Regulation of nonsense-mediated mRNA decay in neural development and disease
Regulation of nonsense-mediated mRNA decay in neural development and disease Open
Eukaryotes have evolved a variety of mRNA surveillance mechanisms to detect and degrade aberrant mRNAs with potential deleterious outcomes. Among them, nonsense-mediated mRNA decay (NMD) functions not only as a quality control mechanism ta…
View article: Genetic Risk of Autism Spectrum Disorder in a Pakistani Population
Genetic Risk of Autism Spectrum Disorder in a Pakistani Population Open
Autism spectrum disorder (ASD) is a group of complex multifactorial neurodevelopmental and neuropsychiatric disorders in children characterized by impairment of communication and social interaction. Several genes with associated single nuc…
View article: A Quantitative Study of Empty Baskets in Essential Tremor and Other Motor Neurodegenerative Diseases
A Quantitative Study of Empty Baskets in Essential Tremor and Other Motor Neurodegenerative Diseases Open
The underlying biology of essential tremor (ET) is poorly understood. Purkinje cell (PC) loss has been observed in some studies, although this finding remains somewhat controversial. Basket cells are interneurons whose axonal collaterals f…
View article: Molecular pathway analysis towards understanding tissue vulnerability in spinocerebellar ataxia type 1
Molecular pathway analysis towards understanding tissue vulnerability in spinocerebellar ataxia type 1 Open
The neurodegenerative disorder spinocerebellar ataxia type 1 (SCA1) affects the cerebellum and inferior olive, though previous research has focused primarily on the cerebellum. As a result, it is unknown what molecular alterations are pres…
View article: The Clinical Analysis of the Nasal Septal Cartilage by Measurement Using Computed Tomography
The Clinical Analysis of the Nasal Septal Cartilage by Measurement Using Computed Tomography Open
Measuring the size of septal cartilage using brightness difference is more precise and reliable than previously reported methods. This method can be utilized as the standard for prevention of postoperative complication.
View article: Clinical Analysis of Lobular Keloid after Ear Piercing
Clinical Analysis of Lobular Keloid after Ear Piercing Open
Histological perivascular inflammation is a prominent feature of lobular keloids. Proper surgical treatment, adjuvant treatments, and persistent follow-up observation were sufficient in maintaining a relatively low rates of recurrence.
View article: Improvement of Infraorbital Rim contour Using Medpor
Improvement of Infraorbital Rim contour Using Medpor Open
Because of the safeness, short recovery time, effectiveness, reliability, and potential application to a wide range of facial disproportion problems, this surgical technique can be applied to midfacial retrusion from a variety of etiologie…