Paul A.M. Smeets
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View article: Gastric Digestion and Changes in Serum Amino Acid Concentrations after Consumption of Casein from Cow and Goat Milk: A Randomized Crossover Trial in Healthy Males
Gastric Digestion and Changes in Serum Amino Acid Concentrations after Consumption of Casein from Cow and Goat Milk: A Randomized Crossover Trial in Healthy Males Open
Cow and goat MC have different coagulating properties, as inferred by AA concentrations and supported by image texture analysis. However, overall gastric emptying and the emptying of the liquid and coagulated fractions were similar. This w…
View article: Impact of mechanical and bolus properties on static and dynamic in vitro gastric protein digestion of plant-based meat analogues
Impact of mechanical and bolus properties on static and dynamic in vitro gastric protein digestion of plant-based meat analogues Open
Increased food hardness can reduce proteolysis during gastric digestion, but can also lead to smaller bolus particles during mastication, which can enhance proteolysis. The joint influence of mechanical and bolus properties on gastric moti…
View article: Age and Body Mass Index are associated with Dorsolateral Prefrontal Cortex Activation in Response to Unhealthy Food Cues
Age and Body Mass Index are associated with Dorsolateral Prefrontal Cortex Activation in Response to Unhealthy Food Cues Open
Unhealthy food cues are omnipresent and promote overconsumption. Although childhood obesity rates are increasing, there is no strict regulation of the marketing of unhealthy foods towards children. This is problematic since the human brain…
View article: Perceptual differences in olfactory fat discrimination are not detected in neural activation
Perceptual differences in olfactory fat discrimination are not detected in neural activation Open
Olfaction is involved in detecting, identifying, and discriminating dietary fat within foods, yet the underlying neural mechanisms remain uncharted. Our functional magnetic resonance imaging (fMRI) study investigated the neural correlates …
View article: Influence of structural properties of textured vegetable proteins on in vitro gastric digestion kinetics of plant-based meat analogue patties
Influence of structural properties of textured vegetable proteins on in vitro gastric digestion kinetics of plant-based meat analogue patties Open
Textured vegetable proteins (TVPs) differ in structural properties that may affect the protein digestion of TVP-based meat analogues. This study explored the influence of structural properties on in vitro gastric protein digestion of TVPs …
View article: Magnetization transfer MRI of intragastric milk digestion: A feasibility study in humans
Magnetization transfer MRI of intragastric milk digestion: A feasibility study in humans Open
Gastric milk protein coagulation has been extensively studied using in vitro and animal models. Yet, verifying these results in humans remains essential. In this study, we assessed the feasibility of using MT MRI for monitoring milk protei…
View article: Impact of microstructure of whey protein gels on in vitro gastric protein digestion is sustained after oral structural breakdown by mastication
Impact of microstructure of whey protein gels on in vitro gastric protein digestion is sustained after oral structural breakdown by mastication Open
Gastric protein digestion can be influenced by food micro- and macrostructure. Understanding the interplay between microstructure and macrostructural breakdown during oral processing is crucial to enhance the nutritional value of protein-r…
View article: Intra‐ and interindividual variability in fasted gastric content volume
Intra‐ and interindividual variability in fasted gastric content volume Open
Background Gastric fluid plays a key role in food digestion and drug dissolution, therefore, the amount of gastric fluid present in a fasted state may influence subsequent digestion and drug delivery. We aimed to describe intra‐ and interi…
View article: Pubertal Development and Body Mass Index are associated with Dorsolateral Prefrontal Cortex Activation in Response to Unhealthy Food Cues
Pubertal Development and Body Mass Index are associated with Dorsolateral Prefrontal Cortex Activation in Response to Unhealthy Food Cues Open
Unhealthy food cues are omnipresent and promote overconsumption. Although childhood obesity rates are increasing, there is no strict regulation of the marketing of unhealthy foods towards children. This is problematic since children’s brai…
View article: Age and body mass index are associated with dorsolateral prefrontal cortex activation in response to unhealthy food cues
Age and body mass index are associated with dorsolateral prefrontal cortex activation in response to unhealthy food cues Open
Unhealthy food cues are omnipresent and promote overconsumption. Although childhood obesity rates are increasing, there is no strict regulation of the marketing of unhealthy foods towards children. This is problematic since the human brain…
View article: Magnetization Transfer MRI of intragastric milk digestion: a feasibility study in humans
Magnetization Transfer MRI of intragastric milk digestion: a feasibility study in humans Open
Gastric milk protein (MP) coagulation has been extensively studied using in vitro and animal models. Yet, verifying these results in humans remains essential. Recently, we demonstrated that 1 H Magnetization Transfer (MT) MRI can be used f…
View article: Gastric digestion and changes in serum amino acid concentrations after consumption of casein from cow and goat milk: a randomized crossover trial in healthy men
Gastric digestion and changes in serum amino acid concentrations after consumption of casein from cow and goat milk: a randomized crossover trial in healthy men Open
Background In vitro studies show that goat milk proteins form less compact coagulates in the stomach compared to cow milk proteins, which may facilitate gastric digestion and amino acid (AA) absorption. However, this has not been confirmed…
View article: Intra- and interindividual variability in fasted gastric content volume
Intra- and interindividual variability in fasted gastric content volume Open
2 Abstract Background Gastric fluid plays a key role in food digestion and drug dissolution, therefore, the amount of gastric fluid present in a fasted state may influence subsequent digestion and drug delivery. We aimed to describe intra-…
View article: Correction: Gastric coagulation and postprandial amino acid absorption of milk is affected by mineral composition: a randomized crossover trial
Correction: Gastric coagulation and postprandial amino acid absorption of milk is affected by mineral composition: a randomized crossover trial Open
Correction for ‘Gastric coagulation and postprandial amino acid absorption of milk is affected by mineral composition: a randomized crossover trial’ by Elise J. M. van Eijnatten et al. , Food Funct. , 2024, 15 , 3098–3107, https://doi.org/…
View article: Gastric coagulation and postprandial amino acid absorption of milk is affected by mineral composition: a randomized crossover trial
Gastric coagulation and postprandial amino acid absorption of milk is affected by mineral composition: a randomized crossover trial Open
Mineral composition of milk can influence postprandial serum amino acid kinetics, likely due to differences in coagulation dynamics.
View article: Milk coagulation and gastric emptying in women experiencing gastrointestinal symptoms after ingestion of cow's milk
Milk coagulation and gastric emptying in women experiencing gastrointestinal symptoms after ingestion of cow's milk Open
Background Gastrointestinal symptoms after drinking milk are often attributed to lactose intolerance or cow's milk allergy. However, some individuals without either condition still report gastrointestinal symptoms after drinking milk. This…
View article: Interplay between microstructure, mechanical properties, macrostructure breakdown and in vitro gastric digestion of whey protein gels
Interplay between microstructure, mechanical properties, macrostructure breakdown and in vitro gastric digestion of whey protein gels Open
Gastric digestion of proteins is influenced by multiple factors including microstructure, mechanical properties and structure breakdown during mastication. The interplay between these factors affects protein digestion but is underexplored.…
View article: Gastric coagulation and postprandial amino acid absorption of milk is affected by mineral composition: a randomized crossover trial
Gastric coagulation and postprandial amino acid absorption of milk is affected by mineral composition: a randomized crossover trial Open
Background In vitro studies suggest that casein coagulation of milk is influenced by its mineral composition, and may therefore affect the dynamics of protein digestion, gastric emptying and appearance of amino acids (AA) in the blood, but…
View article: Gastric emptying and nutrient absorption of pea protein products differing in heat treatment and texture: a randomized<i>in vivo</i>crossover trial and<i>in vitro</i>digestion study
Gastric emptying and nutrient absorption of pea protein products differing in heat treatment and texture: a randomized<i>in vivo</i>crossover trial and<i>in vitro</i>digestion study Open
Background Pea protein is an interesting alternative for animal-based proteins due to its good availability, low cost and relatively balanced amino acid (AA) profile. Its digestibility may be affected by heat treatment and food texture. Ob…
View article: Intragastric behavior of an experimental infant formula may better mimic intragastric behavior of human milk as compared to a control formula
Intragastric behavior of an experimental infant formula may better mimic intragastric behavior of human milk as compared to a control formula Open
Background During breastfeeding the macronutrient composition of breastmilk changes gradually from relatively low-fat (foremilk) to relatively high-fat (hindmilk), initially exposing the gastrointestinal tract to a relatively low fat conce…
View article: Inhibitory control as a potential treatment target for obesity
Inhibitory control as a potential treatment target for obesity Open
OBJECTIVES: Strong reward responsiveness to food and insufficient inhibitory control are thought to be implicated in the development and maintenance of obesity. This narrative review addresses the role of inhibitory control in obesity and …
View article: In vitro 1H MT and CEST MRI mapping of gastro-intestinal milk protein breakdown
In vitro 1H MT and CEST MRI mapping of gastro-intestinal milk protein breakdown Open
Protein digestion is commonly studied using in vitro models. Validating these models with more complex in vivo observations remains challenging, in particular due to the need for non-invasive techniques. Here, we explore Magnetization Tran…
View article: The potential for clinical application of automatic quantification of olfactory bulb volume in MRI scans using convolutional neural networks
The potential for clinical application of automatic quantification of olfactory bulb volume in MRI scans using convolutional neural networks Open
The olfactory bulbs (OBs) play a key role in olfactory processing; their volume is important for diagnosis, prognosis and treatment of patients with olfactory loss. Until now, measurements of OB volumes have been limited to quantification …
View article: The effect of hunger state on hypothalamic functional connectivity in response to food cues
The effect of hunger state on hypothalamic functional connectivity in response to food cues Open
The neural underpinnings of the integration of internal and external cues that reflect nutritional status are poorly understood in humans. The hypothalamus is a key integrative area involved in short‐ and long‐term energy intake regulation…